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LMCB - MRC Laboratory for Molecular Cell Biology

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Alison Lloyd's picture
LMCB Group Leader, UCL Professor of Cell Biology
 
+44 (0)20 7679 2240
LMCB Room 1.03
 
Cell Biogenesis and Tissue Regeneration

Research Synopsis

A regenerative tissue must be able to switch between different states; a stable, functional tissue that remains more or less the same for the lifespan of the animal and a repairing tissue that aims to return to the homeostatic state. Peripheral nerve is such a tissue; highly quiescent and architecturally stable during adulthood, it retains remarkable regenerative capabilities. Critical to this process is the Schwann cell, the major glial cell of the Peripheral Nervous System (PNS). In the adult, Schwann cells are normally quiescent and associated with axons, however, in response to injury, these cells undergo a dramatic change in cell-state to a more progenitor-like state and these cells orchestrate the multicellular response required for nerve regeneration. Using a combination of powerful in vitro and in vivo models, advanced imaging technologies and molecular analyses, our lab explores fundamental questions associated with these changes in cell state and how addressing these questions provide insight into pathologies such as cancer, neuropathies and pain. These questions include: How is a stable adult tissue established and maintained? How does a tissue switch to a regenerative state following injury and then return to the homeostatic state? How are regenerative processes such as proliferation, inflammation, cell biogenesis and cell migration co-opted during tumourigenesis?
 

Funders

Cancer Research UK
Medical Research Council
Wellcome Trust
Rosetrees Foundation
Worldwide Cancer Research
 

Research Themes

Tissue homeostasis, Tissue regeneration, Cancer biology, Peripheral nerve biology, Cell Biogenesis, Heterotypic and homotypic cell-cell interactions, Cell size control

Technology

Light microscopy, 3D imaging, Translational Research, Bioinformatics, Super-resolution microscopy, Electron Microscopy, In vivo models, Primary culture models
 

People

Rosalba Camicia (Postdoctoral Fellow)
Anne Laure Cattin (Postdoctoral Fellow)
Elizabeth Harford-Wright (Postdoctoral Fellow)
Julian Goving (Postdoctoral Fellow)
Valerio Imperatore (PhD student)
Liza Malong (PhD student) 
Lucie Van Emmenis (PhD Student)
Salome Steirli (PhD student)
Anthony Monteza Cabrejos (Research Assistant)
 

Collaborators

Sophie Acton (LMCB, UK)
Antonella Riccio (LMCB, UK)

Ricardo Henriques (LMCB, UK)

Robin Ketteler (LMCB, UK)

Bill Richardson (UCL, UK)

Simona Parrinello (UCL, UK)
Adrienne Flanagan (UCL, UK)
Tariq Enver (UCL, UK)

Clare Bennett (UCL, UK)
David Parkinson (Plymouth, UK)