The mechanisms used by viruses to invade and replicate in cells are of fundamental interest, both in terms of improved understanding of infection and pathogenesis, with implications for health and economic wellbeing, but also because viruses are extraordinary tools for revealing how cells work.
We focus on understanding how membrane-containing enveloped viruses interact with cellular membrane systems, how these interactions facilitate or restrict the transmission of viruses from cell to cell and how they impact on viral pathogenesis. We are exploiting our current knowhow to develop knowledge-based interventions against viral infections and/or pathogenesis.
Recently, we have concentrated on HIV, and the closely related simian immunodeficiency viruses (SIV), with a view to understanding fundamental aspects of virus replication in macrophages and how highly conserved trafficking signals in the envelope glycoprotein of SIV impact on pathogenesis.
In new programs of work, we will investigate (1) how interferon-induced transmembrane (IFITM) proteins inhibit the entry of a broad range of enveloped viruses, (2) the potential to develop broad-spectrum antivirals that inhibit the entry of viruses that exploit the same endocytic entry mechanisms, and (3) the cell biological processes underlying virus particle formation.
UCL Confidence in Concept
The National Institutes of Health
Virus entry, Membrane trafficking, Cellular mechanisms of viral restriction, Viral pathogenesis
Light microscopy, Translational research, Bioinformatics, Electron microscopy
Ricardo Henriques (LMCB, UK)
Jason Mercer (LMCB, UK)
Ewa Paluch (LMCB, UK)
Dan Cutler (LMCB, UK)
Franck Pichaud (LMCB, UK)
Chris Stefan (LMCB, UK)
Robin Ketteler (LMCB, UK)
Jim Hoxie (University of Pennsylvania, USA)
Mark von Zastrow (UCSF, USA)
Andrew Shevchuk (Imperial College, UK)
Greg Towers (UCL, UK)
Isabel Llorente-Garcia (UCL, UK)
Paul Kellam (Imperial College, UK)
Mike Jacobs (UCL, UK)
Richard Angel (UCL, UK)
Sandip Patel (UCL, UK)