Cell-cell communication is tightly coupled to membrane trafficking pathways that control the secretion of signaling factors and the targeting of cell-surface receptors. Our group is investigating the structural requirements and physiological roles for phosphoinositide (PI) kinase regulatory networks in cell signaling and membrane trafficking pathways. This work is revealing novel roles for ‘intracellular synapses’ between the between the endoplasmic reticulum (ER) and plasma membrane (PM). We are addressing how the assembly and disassembly of ER-PM junctions are regulated and how the architecture of distinct ER-PM junctions modulate PI lipid metabolism and utilization. We are also using system-wide approaches to identify novel targets and regulators of PI kinase signaling networks. We expect these studies to reveal important new insights into how disruptions in PI kinase signaling and ER-PM cross talk are involved in various human diseases.
Medical Research Council
Signalling pathways, Membrane trafficking
Light microscopy, Translational research, Bioinformatics, Super-resolution microscopy, Electron microscopy
Taki Nishimura (Postdoctoral Research Associate, JSPS)
Angela Cadou (Postdoctoral Research Associate)
Gary Chung (Postdoctoral Fellow)