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Chris Stefan's picture

LMCB Group Leader, UCL Reader


c.stefan@ucl.ac.uk
+44 (0)20 7679 7208
LMCB Room 3.01


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PI Kinase Signalling and Membrane Dynamics

Research Synopsis

Cell-cell communication is tightly coupled to membrane trafficking pathways that control the secretion of signaling factors and the targeting of cell-surface receptors. Our group is investigating the structural requirements and physiological roles for phosphoinositide (PI) kinase regulatory networks in cell signaling and membrane trafficking pathways. This work is revealing novel roles for ‘intracellular synapses’ between the between the endoplasmic reticulum (ER) and plasma membrane (PM). We are addressing how the assembly and disassembly of ER-PM junctions are regulated and how the architecture of distinct ER-PM junctions modulate PI lipid metabolism and utilization. We are also using system-wide approaches to identify novel targets and regulators of PI kinase signaling networks. We expect these studies to reveal important new insights into how disruptions in PI kinase signaling and ER-PM cross talk are involved in various human diseases.

Selected Publications

Stefan CJ (2018). Building ER-PM contacts: keeping calm and ready on alarm. Curr Opin Cell Biol. 2018 Apr 3;53:1-8. doi: 10.1016/j.ceb.2018.03.008.
Stefan CJ, et al (2017). Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers. BMC Biol. 2017 Oct 31;15(1):102. doi: 10.1186/s12915-017-0432-0.
Omnus DJ, et al (2016). Phosphoinositide kinase signaling controls ER-PM cross-talk. Mol Biol Cell, 27 (7), 1170-1180. doi:10.1091/mbc.E16-01-0002
Henne WM, et al (2015). Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein. J Cell Biol, 210 (4), 541-551. doi:10.1083/jcb.201503088

 

 

Funders

Medical Research Council

Research Themes

Signalling pathways, Membrane trafficking

Technology

Light microscopy, Translational research, Bioinformatics,  Super-resolution microscopy, Electron microscopy

People

Taki Nishimura (Postdoctoral Research Associate, JSPS)
Angela Cadou (Postdoctoral Research Associate)
Gary Chung (Postdoctoral Fellow)

Collaborators

Mark Marsh (LMCB, UK)
Franck Pichaud (LMCB, UK)
Dan Cutler (LMCB, UK)
Jason Mercer (LMCB, UK)
Jemima Burden (LMCB, UK)
Christian Ungermann (Osnabruck University, Germany)
Ruben Fernandez Busnadiego (Max Planck Institute, Germany)