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Chris Stefan's picture

LMCB Group Leader, UCL Reader


c.stefan@ucl.ac.uk
+44 (0)20 7679 7208
LMCB Room 3.01


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PI Kinase Signalling and Membrane Dynamics

Research Synopsis

Cell-cell communication is tightly coupled to membrane trafficking pathways that control the secretion of signaling factors and the targeting of cell-surface receptors. Our group is investigating the structural requirements and physiological roles for phosphoinositide (PI) kinase regulatory networks in cell signaling and membrane trafficking pathways. This work is revealing novel roles for ‘intracellular synapses’ between the between the endoplasmic reticulum (ER) and plasma membrane (PM). We are addressing how the assembly and disassembly of ER-PM junctions are regulated and how the architecture of distinct ER-PM junctions modulate PI lipid metabolism and utilization. We are also using system-wide approaches to identify novel targets and regulators of PI kinase signaling networks. We expect these studies to reveal important new insights into how disruptions in PI kinase signaling and ER-PM cross talk are involved in various human diseases.

Selected Publications

Omnus DJ, et al (2016). Phosphoinositide kinase signaling controls ER-PM cross-talk. MOLECULAR BIOLOGY OF THE CELL, 27 (7), 1170-1180. doi:10.1091/mbc.E16-01-0002
Henne WM, et al (2015). Mdm l/Snx 13 is a novel ER-endolysosomal interorganelle tethering protein. JOURNAL OF CELL BIOLOGY, 210 (4), 541-551. doi:10.1083/jcb.201503088
Stefan CJ, et al (2013). ER–PM connections: sites of information transfer and inter-organelle communication. Current Opinion in Cell Biology, 25 (4), 434-442. doi:10.1016/j.ceb.2013.02.020
Manford AG, et al (2012). ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology. Developmental Cell, 23 (6), 1129-1140. doi:10.1016/j.devcel.2012.11.004

Funders

Medical Research Council

Research Themes

Signalling pathways, Membrane trafficking

Technology

Light microscopy, Translational research, Bioinformatics,  Super-resolution microscopy, Electron Microscopy

People

Taki Nishimura (Postdoctoral Research Associate, JSPS)
Angela Cadou (Postdoctoral Research Associate)
Gary Chung (Postdoctoral Fellow)
Deike Omnus (Postdoctoral Fellow)

Collaborators

Mark Marsh (LMCB, UK)
Ewa Paluch (LMCB, UK)
Franck Pichaud (LMCB, UK)
Dan Cutler (LMCB, UK)
Jason Mercer (LMCB, UK)
Christian Ungermann (Osnabruck University, Germany)
Ruben Fernandez Busnadiego (Max Planck Institute, Germany)