Mark Marsh Research Group

1975, BSc University of London, London UK
1979, PhD University of London, London UK
Mark Marsh
Tel: 020 7679 7807
Fax: 020 7679 7805
Awards: 
1979, Royal Society Postdoctoral Fellowship
1982, European Molecular Biology Organisation Postdoctoral Fellowship
2000, Professor of Molecular Cell Biology, UCL, London
2007, Alexander von Humboldt Foundation Research Award
2011, EMBO Member
Previous Posts: 
1979-1981 Postdoctoral Fellow, EMBL, Heidelberg
1981-1985 Postdoctoral Fellow, Yale University Medical School
1985-1991 Group Leader, Institute of Cancer Research, London
1992- Group Leader, MRC Laboratory for Molecular Cell Biology, UCL, London

Virus cell biology

marsh1_0.jpg

HIV particle budding from an infected HeLa cell. Small gold particles label the Gag structural protein p24/p55; the large gold particles label Env. Scale bar = 100 nm. A. Pelchen-Matthews

We aim to understand aspects of the cellular and molecular mechanisms that underlie the replication of mammalian viruses, specifically how viruses enter target cells, and how new virus particles are assembled and released from infected cells. We currently use HIV-1 and the related simian viruses as models where detailed understanding of cell biology may have application in the development of novel inhibitors or treatments.

Virus entry and productive infection generally require the expression of specific cell surface receptor molecules on target cells. In many cases, virus-receptor binding is followed by endocytosis and viral penetration from within intracellular organelles, usually endosomes. For some viruses, including HIV, the reactions that drive membrane fusion are initiated when the virus engages cell surface receptors – for HIV the co-receptors CD4 plus a chemokine receptor (CCR5 or CXCR4). These infection events can be abrogated by down regulating the cell surface expression of the receptor either by specifically inhibiting synthesis or inducing receptor internalisation and removal from the cell surface. For example, small molecules that inhibit the synthesis of specific cell surface receptors can, in culture systems at least, prevent HIV infection. Agonistic receptor-binding ligands can also be used to induce receptor internalisation and inhibit infection. We are trying to understand the cellular and molecular mechanisms underlying these processes, in particular the events regulating the cell surface expression and endocytosis of HIV-binding co-receptors CCR5 and CXCR4. As these molecules are G protein coupled receptors, our work may have relevance to understanding the trafficking events controlling the functions of other GPCRs. Moreover, our approaches can be applied to further understand other complex virus receptor systems.

We are using a range of morphological approaches, including live cell imaging and EM, to understand how CCR5 and CXCR4 are recruited to endocytic clathrin coated pits following agonist binding. We are particularly intrigued to understand the role of large clathrin lattice domains in these events. The clathrin domains we have analysed are found on the dorsal surface of cells and hence do not appear to have a role in cell-substrate adhesion (though large lattice structures are also seen on the adherent, ventral surfaces of cells), but their function remains to be determined. We also aim to determine how CCR5 molecules in particular are rapidly sorted in early endosomes for delivery to recycling endosomes, and the possible role of co-internalised beta-arrestin molecules in these events. Image-based approaches using the new high throughput screening facilities in the LMCB are being developed to identify key components and small molecular antagonists.

HIV and SIV assembly requires the key viral structural proteins, Gag, Gag-Pol and Env and the viral RNA genome to be bought together at the same place and time within an infected cell to promote the formation of new virus particles. These events occur through interaction with a series of host cell protein machineries. Although a number of the cellular components involved are known, an integrated model of how and when exactly these interactions occur is not yet available. We have previously defined signals in the HIV and SIV envelope glycoproteins (Env) that control the distribution of these key viral proteins in infected cells. In part at least, these signals interact with the clathrin-based sorting machinery, but the full repertoire of interactions remains to be established. Importantly, in a simian model, one of these signals is required for viral pathogenesis. Gag sorting to plasma membrane domains also involves the activities of a repertoire of cellular machineries, including several protein complexes involved in membrane protein sorting and trafficking. How exactly these host cell proteins are coordinated to produce new virus particles, and how Env is recruited during the budding process, remains to be established.
In differentiated primary macrophages, the viral structural proteins are sorted to a unique intracellularly sequestered plasma membrane domain. This domain, which is continuous with the plasma membrane but is located within the cell, is present in uninfected macrophages, where in some cases at least it contains MHC class II antigens. In HIV infected macrophages, this membrane domain is the principal site for virus assembly, and newly assembled virions are retained within the compartment prior to virus release. These compartments may play a role in the formation and/or function of immune synapses, and can be exploited by the virus for efficient transfer to CD4+ve T cells via so-called virological or infectious synapses. Although EM analysis indicates that new virions are formed at these specialized plasma membrane domains, the features of the membrane that mediate the recruitment of HIV proteins, but are distinct from the cell surface plasma membrane, remain unclear. High through put approaches are being developed to identify key components involved in the formation of these compartments and their ability to facilitate HIV assembly.

HIV particle budding from an infected HeLa cell. Small gold particles label the Gag structural protein p24/p55; the large gold particles label Env. Scale bar = 100 nm. A. Pelchen-Matthews

 

PA

Rachel Hamilton

rachel.hamilton@ucl.ac.uk

0044 (0)207 679 7802

0044 (0)207 679 7805

Lab Members: 
Stephanie Czieso
Sebastian Giese
Meriem Hamoudi
Michela Mazzon
Annegret Pelchen-Matthews
Publications
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Number of items: 162.

2014

Giese, S; Marsh, M; (2014) Tetherin Can Restrict Cell-Free and Cell-Cell Transmission of HIV from Primary Macrophages to T Cells. PLoS Pathog , 10 (7) e1004189 - ?. 10.1371/journal.ppat.1004189.

Marsh, M; McKeating, JA; (2014) Editorial overview - Virus entry: Towards reality - Refining models of virus entry. Current Opinion in Virology , 4 10.1016/j.coviro.2014.01.001.

Smith, S; Weston, S; Kellam, P; Marsh, M; (2014) IFITM proteins-cellular inhibitors of viral entry. Curr Opin Virol , 4C 71 - 77. 10.1016/j.coviro.2013.11.004.

2013

Blondeau, C; Pelchen-Matthews, A; Mlcochova, P; Marsh, M; Milne, RS; Towers, GJ; (2013) Tetherin Restricts Herpes Simplex Virus Type 1 and is Antagonised by Glycoprotein M. J Virol 10.1128/JVI.02250-13.

Mlcochova, P; Pelchen-Matthews, A; Marsh, M; (2013) Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages. BMC Biol , 11 89 - ?. 10.1186/1741-7007-11-89.

Tippett, E; Cameron, PU; Marsh, M; Crowe, SM; (2013) Characterization of tetraspanins CD9, CD53, CD63, and CD81 in monocytes and macrophages in HIV-1 infection. JOURNAL OF LEUKOCYTE BIOLOGY , 93 (6) 913 - 920. 10.1189/jlb.0812391.

Tippett, E; Cameron, PU; Marsh, M; Crowe, SM; (2013) Characterization of tetraspanins CD9, CD53, CD63, and CD81 in monocytes and. Journal of Leukocyte Biology , 93 (6) 913 - 920.

2012

Henry, AG; Hislop, JN; Grove, J; Thorn, K; Marsh, M; von Zastrow, M; (2012) Regulation of Endocytic Clathrin Dynamics by Cargo Ubiquitination. Developmental Cell , 23 (3) 519 - 532. 10.1016/j.devcel.2012.08.003. Green and gold open access
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Pelchen-Matthews, A; Giese, S; Mlčochová, P; Turner, J; Marsh, M; (2012) β2 integrin adhesion complexes maintain the integrity of HIV-1 assembly compartments in primary macrophages. Traffic , 13 (2) 273 - 291. 10.1111/j.1600-0854.2011.01306.x.

Snijder, B; Sacher, R; Raemoe, P; Liberali, P; Mench, K; Wolfrum, N; ... Pelkmans, L; + view all (2012) Single-cell analysis of population context advances RNAi screening at multiple levels. MOLECULAR SYSTEMS BIOLOGY , 8 , Article ARTN 579. 10.1038/msb.2012.9. Gold open access

2011

Alonso, R; Mazzeo, C; Rodriguez, MC; Marsh, M; Fraile-Ramos, A; Calvo, V; ... Izquierdo, M; + view all (2011) Diacylglycerol kinase alpha regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes. CELL DEATH AND DIFFERENTIATION , 18 (7) 1161 - 1173. 10.1038/cdd.2010.184.

Caillet, M; Janvier, K; Pelchen-Matthews, A; Delcroix-Genete, D; Camus, G; Marsh, M; Berlioz-Torrent, C; (2011) Rab7A Is Required for Efficient Production of Infectious HIV-1. PLoS Pathogens , 7 (11) , Article e1002347. 10.1371/journal.ppat.1002347. Green and gold open access
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Grove, J; Marsh, M; (2011) The cell biology of receptor-mediated virus entry. Journal of Cell Biology , 195 (7) 1071 - 1082. 10.1083/jcb.201108131. Green open access
file

Henry, AG; White, IJ; Marsh, M; von Zastrow, M; Hislop, JN; (2011) The Role of Ubiquitination in Lysosomal Trafficking of delta-Opioid Receptors. TRAFFIC , 12 (2) 170 - 184. 10.1111/j.1600-0854.2010.01145.x.

Janvier, K; Pelchen-Matthews, A; Renaud, J-B; Caillet, M; Marsh, M; Berlioz-Torrent, C; (2011) The ESCRT-0 Component HRS is Required for HIV-1 Vpu-Mediated BST-2/Tetherin Down-Regulation. PLoS Pathogens , 7 (2) , Article e1001265. 10.1371/journal.ppat.1001265. Green and gold open access
file

2010

Brodsky, FM; Marsh, M; (2010) Life History of the Journal TRAFFIC, Celebrating Ten Years of Publication. TRAFFIC , 11 (1) 1 - 3. 10.1111/j.1600-0854.2009.01004.x.

2009

Azevedo, C; Burton, A; Ruiz-Mateos, E; Marsh, M; Saiardi, A; (2009) Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release. P NATL ACAD SCI USA , 106 (50) 21161 - 21166. 10.1073/pnas.0909176106.

Gupta, RK; Mlcochova, P; Pelchen-Matthews, A; Petit, SJ; Mattiuzzo, G; Pillay, D; ... Towers, GJ; + view all (2009) Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration. P NATL ACAD SCI USA , 106 (49) 20889 - 20894. 10.1073/pnas.0907075106.

Kershaw, T; Wavre-Shapton, ST; Signoret, N; Marsh, M; (2009) Analysis of chemokine receptor endocytosis and intracellular trafficking. Methods Enzymol , 460 357 - 377. 10.1016/S0076-6879(09)05218-5.

Marsh, M; Theusner, K; Pelchen-Matthews, A; (2009) HIV assembly and budding in macrophages. Biochem Soc Trans , 37 (Pt 1) 185 - 189. 10.1042/BST0370185.

Smith, AM; Rahman, FZ; Hayee, B; Graham, SJ; Marks, DJB; Sewell, GW; ... Segal, AW; + view all (2009) Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J EXP MED , 206 (9) 1883 - 1897. 10.1084/jem.20091233.

Theusner, K; Pelchen-Matthews, A; Marsh, M; (2009) Human Immunodeficiency Virus infection of macrophages - assembly and transmission to T lymphocytes. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION , 39 38 - 38.

2008

Marsh, M; van Meer, G; (2008) Cell biology. No ESCRTs for exosomes. Science , 319 (5867) 1191 - 1192. 10.1126/science.1155750.

Ruiz-Mateos, E; Pelchen-Matthews, A; Deneka, M; Marsh, M; (2008) CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophages. J Virol , 82 (10) 4751 - 4761. 10.1128/JVI.02320-07.

2007

Byland, R; Vance, PJ; Hoxie, JA; Marsh, M; (2007) A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein. Mol Biol Cell , 18 (2) 414 - 425. 10.1091/mbc.E06-06-0535.

Deneka, M; Pelchen-Matthews, A; Byland, R; Ruiz-Mateos, E; Marsh, M; (2007) In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53. J Cell Biol , 177 (2) 329 - 341. 10.1083/jcb.200609050.

Forzan, M; Marsh, M; Roy, P; (2007) Bluetongue virus entry into cells. JOURNAL OF VIROLOGY , 81 (9) 4819 - 4827. 10.1128/JVI.02284-06.

Fraile-Ramos, A; Pelchen-Matthews, A; Risco, C; Rejas, MT; Emery, VC; Hassan-Walker, AF; ... Marsh, M; + view all (2007) The ESCRT machinery is not required for human cytomegalovirus envelopment. CELL MICROBIOL , 9 (12) 2955 - 2967. 10.1111/j.1462-5822.2007.01024.

Fraile-Ramos, A; Pelchen-Matthews, A; Risco, C; Rejas, MT; Emery, VC; Hassan-Walker, AF; ... Marsh, M; + view all (2007) The ESCRT machinery is not required for human cytomegalovirus envelopment. Cell Microbiol , 9 (12) 2955 - 2967. 10.1111/j.1462-5822.2007.01024.x.

Martin-Serrano, J; Marsh, M; (2007) ALIX catches HIV. CELL HOST & MICROBE , 1 (1) 5 - 7. 10.1016/j.chom.2007.02.006.

Pelchen-Matthews, A; Marsh, M; (2007) Electron microscopy analysis of viral morphogenesis. Methods Cell Biol , 79 515 - 542. 10.1016/S0091-679X(06)79020-3.

2006

Marsh, M; (2006) Endosomes - key components in viral entry and replication. In: Dikic, I, (ed.) Endosomes. (132 - 144). Landes Bioscience: Georgetown TX.

Marsh, M; Helenius, A; (2006) Virus entry: open sesame. Cell , 124 (4) 729 - 740. 10.1016/j.cell.2006.02.007.

Pelchen-Matthews and Marsh, M; (2006) EM analysis of viral morphogenesis. In: Mcintosh, RJ, (ed.) Methods in Cell Biology vol Cellular Electron Microscopy. Elsevier Inc: San DIego.

2005

Byland, R; Marsh, M; (2005) Trafficking of viral membrane proteins. In: UNSPECIFIED (219 - 254).

Garcia, E; Pion, M; Pelchen-Matthews, A; Collinson, L; Arrighi, JF; Blot, G; ... Piguet, V; + view all (2005) HIV-1 trafficking to the dendritic cell-T-cell infectious synapse uses a pathway of tetraspanin sorting to the immunological synapse. TRAFFIC , 6 (6) 488 - 501. 10.1111/j.1600-0854.2005.00293.x.

Garcia, E; Pion, M; Pelchen-Matthews, A; Collinson, L; Arrighi, JF; Marsh, M; Piguet, V; (2005) Trafficking of HIV-1 to the dendritic cell-T cell infectious synapse uses DC-SIGN and the pathway of tetraspanin sorting to the immunological synapse. In: JOURNAL OF INVESTIGATIVE DERMATOLOGY. (pp. A81 - A81). BLACKWELL PUBLISHING

Kramer, B; Pelchen-Matthews, A; Deneka, M; Garcia, E; Piguet, V; Marsh, M; (2005) HIV interaction with endosornes in macrophages and dendritic cells. BLOOD CELLS MOLECULES AND DISEASES , 35 (2) 136 - 142. 10.1016/j.bcmd.2005.06.006.

Marsh, M; (2005) Cell biology of virus replication. In: P Cossart, PN and Rappuoli, SNAR, (eds.) Cellular Microbiology. (517 - 542). ASM Press

Marsh, M; (2005) Membrane trafficking and viral replication. Current Topics in Immunology and Microbiology: Vol.285. Springer Verlag: Heidelberg.

Peter, M; Ameer-Beg, SM; Hughes, MKY; Keppler, MD; Prag, S; Marsh, M; ... Ng, T; + view all (2005) Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions. BIOPHYSICAL JOURNAL , 88 (2) 1224 - 1237. 10.1529/biophysj.104.050153.

Signoret, N; Hewlett, L; Wavre, S; Pelchen-Matthews, A; Oppermann, M; Marsh, M; (2005) Agonist-induced endocytosis of CC chemokine receptor 5 is clathrin dependent. Mol Biol Cell , 16 (2) 902 - 917. 10.1091/mbc.E04-08-0687.

2004

Marsh, M; Signoret, N; Wavre, S; Fraile-Ramos, A; Pelchen-Matthews, A; Hewlett, L; (2004) Endocytosis of cellular and viral chemokine receptors. In: EUROPEAN JOURNAL OF CELL BIOLOGY. (pp. 74 - 74).

Pelchen-Matthews, A; Raposo, G; Marsh, M; (2004) Endosomes, exosomes and Trojan viruses. Trends Microbiol , 12 (7) 310 - 316. 10.1016/j.tim.2004.05.004.

Signoret, N; Christophe, T; Oppermann, M; Marsh, M; (2004) pH-independent endocytic cycling of the chemokine receptor CCR5. Traffic , 5 (7) 529 - 543.

2003

Bijlmakers, MJ; Marsh, M; (2003) The on-off story of protein palmitoylation. TRENDS IN CELL BIOLOGY , 13 (1) , Article PII S0962-8924(02)00008-9. 10.1016/S0962-8924(02)00008-9.

Fraile-Ramos, A; Kohout, TA; Waldhoer, M; Marsh, M; (2003) Endocytosis of the viral chemokine receptor US28 does not require beta-arrestins but is dependent on the clathrin-mediated pathway. Traffic , 4 (4) 243 - 253.

Marsh, M; Thali, M; (2003) HIV's great escape. NATURE MEDICINE , 9 (10) 1262 - 1263. 10.1038/nm1003-1262.

Pelchen-Matthews, A; Kramer, B; Marsh, M; (2003) Infectious HIV-1 assembles in late endosomes in primary macrophages. J Cell Biol , 162 (3) 443 - 455. 10.1083/jcb.200304008.

2002

Fraile-Ramos, A; Marsh, M; (2002) Endocytosis of the viral chemokine receptor US28 does not require beta-arrestins. In: MOLECULAR BIOLOGY OF THE CELL. (pp. 365A - 365A).

Fraile-Ramos, A; Pelchen-Matthews, A; Kledal, TN; Browne, H; Schwartz, TW; Marsh, M; (2002) Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes. Traffic , 3 (3) 218 - 232.

Marsh, M; Pelchen-Matthews, A; Kramer, B; Fraile-Ramos, A; (2002) Virus assembly in the endocytic pathway. In: MOLECULAR BIOLOGY OF THE CELL. (pp. 7A - 7A).

Martini, L; Hastrup, H; Holst, B; Fraile-Ramos, A; Marsh, M; Schwartz, TW; (2002) NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype. MOLECULAR PHARMACOLOGY , 62 (1) , Article UNSP 1524/991021. 10.1124/mol.62.1.30.

2001

Marsh, M (Ed). (2001) Endocytosis. Frontiers in Molecular Biology. Oxford University Press: Oxford.

Fraile-Ramos, A; Kledal, TN; Pelchen-Matthews, A; Bowers, K; Schwartz, TW; Marsh, M; (2001) The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling. MOL BIOL CELL , 12 (6) 1737 - 1749. Green open access
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Fultz, PN; Vance, PJ; Endres, MJ; Tao, BL; Dvorin, JD; Davis, IC; ... Hoxie, JA; + view all (2001) In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail. JOURNAL OF VIROLOGY , 75 (1) 278 - 291. 10.1128/JVI.75.1.278-291.2001.

Marsh, M; (2001) An all too visible adversary. 317-318 Book review - ?.

Russell, DG; Marsh, M; (2001) Endocytosis in pathogen entry and replication. In: Marsh, M, (ed.) Endocytosis. (247 - 280). Oxford University Press: Oxford.

Signoret, N; Pelchen-Matthews, A; Marsh, M; (2001) pH independent sorting and recycling of the chemokine receptor CCR5. In: MOLECULAR BIOLOGY OF THE CELL. (pp. 253A - 253A).

2000

Bijlmakers, MJ; Marsh, M; (2000) Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck). Mol Biol Cell , 11 (5) 1585 - 1595.

Bowers, K; Pelchen-Matthews, A; Honing, S; Vance, PJ; Creary, L; Haggarty, BS; ... Marsh, M; + view all (2000) The simian immunodeficiency virus envelope glycoprotein contains multiple signals that regulate its cell surface expression and endocytosis. TRAFFIC , 1 (8) 661 - 674.

Fraile-Ramos, A; Kledal, TN; Schwartz, TW; Marsh, M; (2000) The human cytomegalovirus chemokine receptor US28 undergoes constitutive endocytosis and recycling. MOLECULAR BIOLOGY OF THE CELL , 11 503A - 503A.

Marsh, M; (2000) Receptor-mediated endocytosis. In: Encyclopaedia of Life Science. Macmillan Reference Ltd.

Marsh, M; Pelchen-Matthews, A; (2000) Endocytosis in viral replication. Traffic , 1 (7) 525 - 532.

Marsh, M; Signoret, N; Pelchen-Matthews, A; (2000) Endocytosis and recycling of the HIV co-receptor CCR5. In: MOLECULAR BIOLOGY OF THE CELL. (pp. 141A - 141A).

Signoret, N; Marsh, M; (2000) Analysis of chemokine receptor endocytosis and recycling. Methods Mol Biol , 138 197 - 207. 10.1385/1-59259-058-6:197.

Signoret, N; Pelchen-Matthews, A; Mack, M; Proudfoot, AE; Marsh, M; (2000) Endocytosis and recycling of the HIV coreceptor CCR5. J Cell Biol , 151 (6) 1281 - 1294.

1999

Bijlmakers, MJ; Marsh, M; (1999) Trafficking of an acylated cytosolic protein: newly synthesized p56(lck) travels to the plasma membrane via the exocytic pathway. J Cell Biol , 145 (3) 457 - 468.

Guinamard, R; Signoret, N; Masamichi, I; Marsh, M; Kurosaki, T; Ravetch, JV; (1999) B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1 alpha chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4. JOURNAL OF EXPERIMENTAL MEDICINE , 189 (9) 1461 - 1466. 10.1084/jem.189.9.1461.

Klasse, PJ; Rosenkilde, MM; Signoret, N; Pelchen-Matthews, A; Schwartz, TW; Marsh, M; (1999) CD4-Chemokine receptor hybrids in human immunodeficiency virus type 1 infection. J Virol , 73 (9) 7453 - 7466.

Lord, JM; Marsh, M; (1999) Endocytosis. In: Creighton, TE, (ed.) Encyclopaedia of Molecular Biology. (809 - 812). John Wiley and Sons, Inc.: New York.

Lord, JM; Marsh, M; (1999) Endosomes. In: Creighton, TE, (ed.) Encyclopaedia of Molecular Biology. (818 - 819). John Wiley and Sons, Inc.: New York.

Lord, JM; Marsh, M; (1999) Macropinosomes. In: Creighton, TE, (ed.) Encyclopaedia of Molecular Biology. (1430 - ?). John Wiley and Sons, Inc.: New York.

Lord, JM; Marsh, M; (1999) Phagocytosis. In: Creighton, TE, (ed.) Encyclopaedia of Molecular Biology. (1822 - ?). John Wiley and Sons, Inc.: New York.

Lord, JM; Marsh, M; (1999) Pinocytosis. In: Creighton, TE, (ed.) Encyclopaedia of Molecular Biology. (1860 - 1861). John Wiley and Sons, Inc.: New York.

Marsh, M; (1999) A new Nature. Trends in Cell Biology , 9 (421)

Marsh, M; McMahon, HT; (1999) The structural era of endocytosis. Science , 285 (5425) 215 - 220.

Pelchen-Matthews, A; Signoret, N; Klasse, PJ; Fraile-Ramos, A; Marsh, M; (1999) Chemokine receptor trafficking and viral replication. Immunol Rev , 168 33 - 49.

Pitcher, C; Honing, S; Fingerhut, A; Bowers, K; Marsh, M; (1999) Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation. MOL BIOL CELL , 10 (3) 677 - 691.

1998

Briant, L; Robert-Hebmann, V; Acquaviva, C; Pelchen-Matthews, A; Marsh, M; Devaux, C; (1998) The protein tyrosine kinase p56lck is required for triggering NF-kappaB activation upon interaction of human immunodeficiency virus type 1 envelope glycoprotein gp120 with cell surface CD4. J Virol , 72 (7) 6207 - 6214.

Klasse, PJ; Bron, R; Marsh, M; (1998) Mechanisms of enveloped virus entry into animal cells. Adv Drug Deliv Rev , 34 (1) 65 - 91.

Mack, M; Luckow, B; Nelson, PJ; Cihak, J; Simmons, G; Clapham, PR; ... Proudfoot, AEI; + view all (1998) Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: A novel inhibitory mechanism of HIV infectivity. JOURNAL OF EXPERIMENTAL MEDICINE , 187 (8) 1215 - 1224. 10.1084/jem.187.8.1215.

Oldridge, J; Marsh, M; (1998) Nef - An adaptor adaptor? Trends in Cell Biology , 8 (8) 302 - 305. 10.1016/S0962-8924(98)01318-X.

Pelchen-Matthews, A; da Silva, RP; Bijlmakers, MJ; Signoret, N; Gordon, S; Marsh, M; (1998) Lack of p56lck expression correlates with CD4 endocytosis in primary lymphoid and myeloid cells. Eur J Immunol , 28 (11) 3639 - 3647.

Signoret, N; Rosenkilde, MM; Klasse, PJ; Schwartz, TW; Malim, MH; Hoxie, JA; Marsh, M; (1998) Differential regulation of CXCR4 and CCR5 endocytosis. J Cell Sci , 111 ( Pt 18) 2819 - 2830.

1997

Bijlmakers, MJ; Isobe-Nakamura, M; Ruddock, LJ; Marsh, M; (1997) Intrinsic signals in the unique domain target p56(lck) to the plasma membrane independently of CD4. J Cell Biol , 137 (5) 1029 - 1040.

Bowers, K; Pitcher, C; Marsh, M; (1997) CD4: a co-receptor in the immune response and HIV infection. Int J Biochem Cell Biol , 29 (6) 871 - 875.

Bron, R; Klasse, PJ; Wilkinson, D; Clapham, PR; PelchenMatthews, A; Power, C; ... Marsh, M; + view all (1997) Promiscuous use of CC and CXC chemokine receptors in cell-to-cell fusion mediated by a human immunodeficiency virus type 2 envelope protein. J VIROL , 71 (11) 8405 - 8415.

Marsh, M; Bron, R; (1997) SFV infection in CHO cells: cell-type specific restrictions to productive virus entry at the cell surface. J Cell Sci , 110 ( Pt 1) 95 - 103.

Marsh, M; Pelchen-Matthews, A; Hoxie, JA; (1997) Roles for endocytosis in lentiviral replication. Trends Cell Biol , 7 (1) 1 - 4. 10.1016/S0962-8924(97)20038-3.

McKnight, A; Wilkinson, D; Simmons, G; Talbot, S; Picard, L; Ahuja, M; ... Clapham, PR; + view all (1997) Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent. J Virol , 71 (2) 1692 - 1696.

Mukherjee, S; Ghosh, RN; Maxfield, FR; (1997) Endocytosis. In: UNSPECIFIED (759 - 803).

Riezman, H; Woodman, PG; Van Meer, G; Marsh, M; (1997) Molecular mechanisms of endocytosis. Cell , 91 (6) 731 - 738. 10.1016/S0092-8674(00)80461-4.

Signoret, N; Oldridge, J; Pelchen-Matthews, A; Klasse, PJ; Tran, T; Brass, LF; ... Marsh, M; + view all (1997) Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J Cell Biol , 139 (3) 651 - 664.

1996

Endres, MJ; Clapham, PR; Marsh, M; Ahuja, M; Turner, JD; McKnight, A; ... Hoxie, JA; + view all (1996) CD4-independent infection by HIV-2 is mediated by Fusin/CXCR4. CELL , 87 (4) 745 - 756. 10.1016/S0092-8674(00)81393-8.

Marsh, M; Helenius, A; Matlin, K; Simons, K; (1996) Binding, endocytosis and degradation of enveloped animal viruses. In: Packer, LAF, (ed.) 'Biomembranes' Selected Methods in Enzymology. (589 - 594). Academic Press: New York/London.

Marsh, M; Pelchen-Matthews, A; (1996) Endocytic and exocytic regulation of CD4 expression and function. Curr Top Microbiol Immunol , 205 107 - 135.

Sauter, MM; PelchenMatthews, A; Bron, R; Marsh, M; LaBranche, CC; Vance, PJ; ... Hoxie, JA; + view all (1996) An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface. The Journal of Cell Biology , 132 (5) 795 - 811. 10.1083/jcb.132.5.795. Green and gold open access

Wells, TNC; ElProudfoot, A; Power, CA; Marsh, M; (1996) Chemokine receptors - The new frontier for AIDS research. CHEMISTRY & BIOLOGY , 3 (8) 603 - 609. 10.1016/S1074-5521(96)90126-X.

1995

Frey, S; Marsh, M; Günther, S; Pelchen-Matthews, A; Stephens, P; Ortlepp, S; Stegmann, T; (1995) Temperature dependence of cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1. J Virol , 69 (3) 1462 - 1472.

LaBranche, CC; Sauter, MM; Haggarty, BS; Vance, PJ; Romano, J; Hart, TK; ... Hoxie, J; + view all (1995) A single amino acid change in the cytoplasmic domain of Simian Immunodeficiency Virus transmembrane molecule increases envelope glycoprotein expression on infected cells. 5217 - 5227.

Pelchen-Matthews, A; Clapham, P; Marsh, M; (1995) Role of CD4 endocytosis in human immunodeficiency virus infection. J Virol , 69 (12) 8164 - 8168.

1994

LEY, S; MARSH, M; BEBBINGTON, C; PROUDFOOT, K; JORDAN, P; (1994) DISTINCT INTRACELLULAR-LOCALIZATION OF LCK AND FYN PROTEIN-TYROSINE KINASES IN HUMAN T-LYMPHOCYTES. JOURNAL OF CELL BIOLOGY , 125 (3) 639 - 649. 10.1083/jcb.125.3.639.

Marsh, M; (1994) Endocytosis. pp 321-322 - ?.

Marsh, M; Pelchen-Matthews, A; (1994) The endocytic pathway and virus entry. 215 - 240.

1993

Futter, C; Marsh, M; (1993) Endocytosis and pasta. Trends Cell Biol , 3 (9) 316 - 318.

Marsh, M; (1993) Biochemical and morphological assays of virus entry. Methods Enzymol , 220 249 - 261.

Marsh, M; (1993) Methods in Enzymology, Volume 219: Reconstitution of Intracellular transport, edited by James E. Rothman (Book review).

Marsh, M; Cutler, D; (1993) Taking the Rabs off endocytosis. Curr Biol , 3 (1) 30 - 32.

Marsh, M; Parsons, IJ; Reid, P; Pelchen-Matthews, A; (1993) Endocytic regulation of the T lymphocyte co-receptor proteins CD4 and CD8. Biochem Soc Trans , 21 ( Pt 3) (3) 703 - 706.

Marsh, M; Pelchen-Matthews, A; (1993) Animal virus entry into cells. 173 - 185.

Marsh, M; Pelchen-Matthews, A; (1993) Entry of animal viruses into cells. Reviews in Medical Virology , 3 (3) 173 - 185.

Paul, NL; Marsh, M; McKeating, JA; Schulz, TF; Liljeström, P; Garoff, H; Weiss, RA; (1993) Expression of HIV-1 envelope glycoproteins by Semliki Forest virus vectors. AIDS Res Hum Retroviruses , 9 (10) 963 - 970.

Pelchen-Matthews, A; Parsons, IJ; Marsh, M; (1993) Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting. J Exp Med , 178 (4) 1209 - 1222.

1992

Marsh, M; (1992) Keeping the viral coat on. Curr Biol , 2 (7) 379 - 381.

Marsh, M; (1992) Traffic jamming (Book review). 32 - ?.

Marsh, M; Pelchen-Matthews, A; (1992) On the role of endocytosis in the entry of animal viruses. 399 - 404.

Marsh, M; Reid, P; Parsons, I; Hermon, C; Pelchen-Matthews, A; (1992) Morphological analysis of the regulation of CD4 endocytosis by p56lck. Biochem Soc Trans , 20 (4) 719 - 724.

Pelchen-Matthews, A; Armes, JE; Marsh, M; (1992) Endocytosis of CD4 in lymphoid and non-lymphoid cells. 355 - 361.

Pelchen-Matthews, A; Boulet, I; Littman, DR; Fagard, R; Marsh, M; (1992) The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits. J Cell Biol , 117 (2) 279 - 290.

Watts, C; Marsh, M; (1992) Endocytosis: What goes in and how? 1 - 8.

1991

Clements, GJ; Price-Jones, MJ; Stephens, PE; Sutton, C; Schulz, TF; Clapham, PR; ... Moore, JP; + view all (1991) The V3 loops of the HIV-1 and HIV-2 surface glycoproteins contain proteolytic cleavage sites: A possible function in viral fusion? AIDS Research and Human Retroviruses , 7 (1) 3 - 16.

Marsh, M; (1991) Endosome and lysosome purification by free flow electrophoresis. 199 - 213..

Pelchen-Matthews, A; Armes, JE; Griffiths, G; Marsh, M; (1991) Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells. J Exp Med , 173 (3) 575 - 587.

1990

Marsh, M; Armes, JE; Pelchen-Matthews, A; (1990) Endocytosis and recycling of CD4. Biochem Soc Trans , 18 (2) 139 - 143.

Marsh, M; Quinn, P; (1990) Membrane cycling through the exocytic and endocytic pathways. pp 421-448 - ?.

McClure, MO; Sommerfelt, MA; Marsh, M; Weiss, RA; (1990) The pH independence of mammalian retrovirus infection. J Gen Virol , 71 ( Pt 4) 767 - 773.

1989

Griffiths, G; Back, R; Marsh, M; (1989) A quantitative analysis of the endocytic pathway in Baby Hamster Kidney cells. 2703 - 2720.

Marsh, M; (1989) Chapter 17 Endosome and Lysosome Purification by Free-Flow Electrophoresis. Methods in Cell Biology , 31 (C) 319 - 334. 10.1016/S0091-679X(08)61617-9.

Marsh, M; Helenius, A; (1989) Virus entry into animal cells. Adv Virus Res , 36 107 - 151.

Pelchen-Matthews, A; Armes, JE; Marsh, M; (1989) Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells. EMBO J , 8 (12) 3641 - 3649.

Sommerfelt, MA; Marsh, M; (1989) Binding and entry of animal viruses. Advanced Drug Delivery Reviews , 4 (1) 1 - 26.

Webster, P; Marsh, M; (1989) Endocytosis by African Trypanosomes. 156 - 160.

Weiss, RA; Clapham, PR; McClure, M; Marsh, M; (1989) The CD4 receptor for the AIDS virus. Biochem Soc Trans , 17 (4) 644 - 647.

Willison, K; Lewis, V; Zuckerman, KS; Cordell, J; Dean, C; Miller, K; ... Marsh, M; + view all (1989) The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes. Cell , 57 (4) 621 - 632.

1988

Marsh, M; (1988) The secretory and exocytic pathways (Book review). 335 - ?.

Marsh, M; Kern, H; Harms, E; Schmid, S; Mellman, I; Helenius, A; (1988) Co-fractionation of BHK-21 cell endosomes and lysosomes by free-flow electrophoresis. Prog Clin Biol Res , 270 21 - 33.

McClure, MO; Marsh, M; Weiss, RA; (1988) Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism. EMBO J , 7 (2) 513 - 518.

1987

Marsh, M; (1987) Enveloped virus entry. pp281 - pp300.

Marsh, M; Dalgleish, A; (1987) How do human immunodeficiency viruses enter cells? Immunology Today , 8 (12) 369 - 371.

Marsh, M; Schmid, S; Kern, H; Harms, E; Male, P; Mellman, I; Helenius, A; (1987) Rapid analytical and preparative isolation of functional endosomes by free flow electrophoresis. Journal of Cell Biology , 104 (4) 875 - 886. 10.1083/jcb.104.4.875.

1986

Kielian, MC; Marsh, M; Helenius, A; (1986) Kinetics of endosome acidification detected by mutant and wild-type Semliki Forest virus. 3103 - 3109.

Marsh, M; Griffiths, G; Dean, GE; Mellman, I; Helenius, A; (1986) Three-dimensional structure of endosomes in BHK-21 cells. Proceedings of the National Academy of Sciences of the United States of America , 83 (9) 2899 - 2903.

Ukkonen, P; Lewis, V; Marsh, M; Helenius, A; Mellman, I; (1986) Transport of macrophage Fc receptors and Fc receptor-bound ligands to lysosomes. 952 - 971.

1985

Lewis, V; Green, S; Marsh, M; Vikko, P; Helenius, A; Mellman, I; (1985) Glycoproteins of the lysosomal membrane. 1839 - 1847.

Mellman, I; Marsh, M; Lewis, V; Ukkonen, P; Green, S; Helenius, A; (1985) The control of membrane transport during endocytosis. Cold Spring Harbour.

1984

Marsh, M; (1984) Entry of enveloped viruses into cells. 1 - 10.

Marsh, M; Helenius, A; (1984) The endocytic pathway in BHK-21 cells as studied with Semliki Forest virus. pp297 - pp313.

Marsh, M; Keilian, M; Helenius, A; (1984) Semliki Forest virus entry and the endocytic pathway. 981 - 983.

1983

Galloway, C; Dean, G; Marsh, M; Rudnick, G; Mellman, I; (1983) Acidification of macrophage and fibroblast endocytic vacuoles in vitro. 3334 - 3338.

Marsh, M; Bolzau, E; Helenius, A; (1983) Semliki Forest virus penetration occurs from acid prelysosomal vacuoles. 931 - 940.

Marsh, M; Bolzau, E; White, J; Helenius, A; (1983) Interaction of subviral components with BHK-21 cells. 455 - 461.

Marsh, M; Helenius, A; Matlin, K; Simons, K; (1983) Binding, endocytosis and degradation of enveloped animal viruses. pp260 - pp266.

1982

Helenius, A; Marsh, M; (1982) Endocytosis of enveloped animal viruses. pp59 - pp69.

Helenius, A; Marsh, M; White, J; (1982) Effect of lysosomotropic weak bases on Semliki Forest virus penetration into host cells. 47 - 61.

Marsh, M; Matlin, K; Simons, K; Reggio, H; White, J; Kartenbeck, J; Helenius, A; (1982) Are lysosomes the site of enveloped virus penetration? 835 - 843.

Marsh, M; Wellsteed, J; Kern, H; Harms, E; Helenius, A; (1982) Monensin inhibits Semliki Forest virus penetration into culture cells. Proc Natl Acad Sci USA , 79 (17) 5297 - 5301. Green open access
file

Marsh, M; Wellsteed, J; Kern, H; Harms, E; Helenius, A; (1982) Monensin inhibits Semliki Forest virus penetration into culture cells. Proc Natl Acad Sci U S A , 79 5297 - 5301.

1981

Gardiner, PR; Miller, RH; Marsh, M; (1981) Studies on the rhizoplast from Naegleria gruberi. 277 - 293.

1980

Helenius, A; Marsh, M; White, J; (1980) The entry of viruses into animal cells. 104 - 106.

Helenius, A; Marsh, M; White, J; (1980) Virus entry into animal cells.

Marsh, M; Helenius, A; (1980) Adsorptive endocytosis of Semliki Forest virus. Journal of Molecular Biology , 142 439 - 454.

This list was generated on Thu Jul 31 22:47:07 2014 BST.