Functional Gene Annotation

Biocuration captures biological knowledge and facilitates its integration into databases thereby making the data easily accessible for visualisation and analysis.

Lead: Professor Ruth Lovering

Group Members: Dr Barbara Kramarz

We curate the scientific literature to provide;

Gene Ontology (GO) annotations to the GO Consortium

Protein interaction data to the IMEx Consortium

The gene product functional information we provide enables researchers to rapidly evaluate and interpret data and generate hypotheses to guide future research into cardiovascular and neurological processes and disease. To date the annotation team at UCL has provided 10% of the manual GO annotations associated with human gene products, and contributed to the creation of almost 3000 new GO terms. We are currently funded by Alzheimer's Research UK and we have previously been funded by the British Heart Foundation and Parkinson's UK to annotate proteins and microRNAs.

People

Neurological Gene Annotation

Research Department of Pre-clinical and Fundamental Science

Cardiovascular Gene Annotation

Biocuration activities

Newsletters

Publications

Teaching

Figure 1. A fragment of a Cytoscape network showing APP gene products being targeted by four different regulatory microRNAs.

Curation Impact

Resources

Cytoscape Tips

PSICQUIC

The Functional Gene Annotation team is supported by Alzheimer's Research UK (grants ARUK-NAS2017A-1 and ARUK-NSG2018-003) and the National Institute for Health Research University College London Hospitals Biomedical Research Centre.

Highlights

Functional Gene Ontology Annotation Newsletter December 2018

In the December issue of our newsletter we congratulate Rachael on her new position at SciBite. Rachael, we will miss you! We also provide a progress update on the GO annotation of microglial proteins and their regulatory microRNAs, and we summarise our participation and contribution to recent meetings. The newsletter also includes a list of publications, which we have recently co-authored, including the article describing our amyloid-beta and tau annotation projects, published last week in Genes. 2018 Nov 29.

Recent Publications

Vadgama N, Lamont D, Hardy J, Nasir J, Lovering RC. Distinct proteomic profiles in monozygotic twins discordant for ischaemic stroke. Mol. Cell. Biochem. 2018 doi: 10.1007/s11010-019-03501-2. [Epub ahead of print] PMID:30694515

Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, ..., O’Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nature Communications. 2018 Dec 3. PMID:30510157.

Kramarz B, Roncaglia P, Meldal BHM, Huntley RP, Martin MJ, Orchard S, Parkinson H, Brough D, Bandopadhyay R, Hooper NM, Lovering RC. Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer’s Disease Data. Genes. 2018 Nov 29. PMID:30501127.