UCL Institute of Cardiovascular Science


Functional Gene Annotation

Biocuration captures biological knowledge and facilitates its integration into databases thereby making the data easily accessible for visualisation and analysis.

Selection of Gene Ontology terms relevant to neuron death

Lead: Professor Ruth Lovering

Students: Renzhi Su

Volunteer biocurators: Marios Makris, Sandra De Miranda Pinheiro, Alice Dashow

We curate the scientific literature to provide;

Gene Ontology (GO) annotations to the GO Consortium

Protein interaction data to the IMEx Consortium

Functional Gene Annotation
The gene product functional information we provide enables researchers to rapidly evaluate and interpret data and generate hypotheses to guide future research into cardiovascular and neurological processes and disease. To date the annotation team at UCL has provided 10% of the manual GO annotations associated with human gene products, and contributed to the creation of almost 3000 new GO terms. We are currently funded by Alzheimer's Research UK and we have previously been funded by the British Heart Foundation and Parkinson's UK to annotate proteins and microRNAs.

The Functional Gene Annotation team is supported by Alzheimer's Research UK grant ARUK-NAS2017A-1 and the National Institute for Health Research University College London Hospitals Biomedical Research Centre. We support the work of the International Society for Biocuration (ISB).

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