Functional Gene Annotation

Lead: Professor Ruth Lovering

Group Members: Dr Barbara Kramarz

We curate the scientific literature to provide;

Gene Ontology (GO) annotations to the GO Consortium

Protein interaction data to the IMEx Consortium

The gene product functional information we provide enables researchers to rapidly evaluate and interpret data and generate hypotheses to guide future research into cardiovascular and neurological processes and disease. To date the annotation team at UCL has provided 10% of the manual GO annotations associated with human gene products, and contributed to the creation of almost 3000 new GO terms. We are currently funded by Alzheimer's Research UK and we have previously been funded by the British Heart Foundation and Parkinson's UK to annotate proteins and microRNAs.

Contribute

You can email us to send information such as:

• A review of the GO terms associated with your favourite gene and tell us what is missing or inaccurate - or let us know if we have done a good job
• Suggestions of papers for curation

The Functional Gene Annotation team is supported by Alzheimer's Research UK grant ARUK-NAS2017A-1 and the National Institute for Health Research University College London Hospitals Biomedical Research Centre.