Cardiovascular Gene Annotation

This initiative focused on the annotation of cardiovascular disease-relevant proteins and microRNAs and was funded by several British Heart Foundation grants from November 2007 to July 2018.

To provide the GO annotations needed to support the cardiovascular research community we have undertaken several focused annotation projects. These processes were prioritised, following discussions with experts in the field and are considered to have important roles in a variety of cardiovascular diseases. GO annotations have facilitated the detailed and high-quality annotation of over 3,600 cardiovascular-relevant human gene products, providing over 32,000 GO annotations, and there are many ways in with the impact of our curation on data analysis and annotation resources can be demonstrated. These annotations were funded by BHF grants (SP/07/007/23671, 2007-2012; RG/13/5/30112, 2013-2018). Annotations contributed by this project to the GO Consortium resource and the IMEx dataset are attributed to BHF-UCL.

The full list of BHF-funded gene products prioritised for annotation, the annotations we have submitted and the Gene Ontology terms we have created are available:

For detailed information about creating GO annotations and GO terms and the overall curation process follow the link below:

Manual curation

To find out more about the heart and cardiovascular system, please see the British Heart Foundation website.

What we curate

Proteins - GO annotations for proteins to the GO Consortium
microRNAs - GO annotations for microRNAs to the GO Consortium
Protein-Protein Interactions - Protein-protein interaction data to the IMEx Consortium

The Functional Gene Annotation team is supported by Alzheimer's Research UK grant ARUK-NAS2017A-1 and the National Institute for Health Research University College London Hospitals Biomedical Research Centre.