The de Bruin lab focuses on two main lines of investigation: (1) elucidating the mechanism and functional importance of the regulation of the cell cycle transcriptional program by the checkpoints that ensure maintenance of genome integrity, and (2) obtaining a better understanding of fundamental regulatory pathways that cause changes in cell cycle-regulated gene expression and the importance of this regulation for the maintenance of genome integrity.

Our work is aimed at understanding, at the molecular level, why defects in proteins ranging from gene-specific transcriptional regulators to global regulators of transcription are associated with human disease, most notably with cancer.