LMCB - MRC Laboratory for Molecular Cell Biology

Rob De Bruin's picture
LMCB Group Leader, UCL Professor of Molecular Cancer Biology
+44 (0)20 7679 7255
LMCB Room B101
Twitter @DeRobertus
Cell Cycle Regulated Transcription and Genome Integrity

Research Synopsis

The de Bruin lab focuses on two main lines of investigation: (1) elucidating the mechanism and functional importance of the regulation of the cell cycle transcriptional program by the checkpoints that ensure maintenance of genome integrity, and (2) obtaining a better understanding of fundamental regulatory pathways that cause changes in cell cycle-regulated gene expression and the importance of this regulation for the maintenance of genome integrity.

Our work is aimed at understanding, at the molecular level, why defects in proteins ranging from gene-specific transcriptional regulators to global regulators of transcription are associated with human disease, most notably with cancer.

de Bruin lab research image

de Bruin lab research image

Selected Publications

Bertoli C, et al (2016). Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage. Cell Reports, 15 (7), 1412-1422. doi:10.1016/j.celrep.2016.04.036
Caetano C, et al (2014). Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability. Cell Rep, 9 (6), 2279-2289. doi:10.1016/j.celrep.2014.11.039
Bertoli C, et al (2013). Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell cycle transcription.Current Biology.
Bertoli C, et al (2013). Control of cell cycle transcription during G1 and S phases. Nat Rev Mol Cell Biol, 14 (8), 518-528. doi:10.1038/nrm3629
de Oliveira FMB, et al (2012). Linking DNA replication checkpoint to MBF cell-cycle transcription reveals a distinct class of G1/S genes. EMBO JOURNAL, 31 (7), 1798-1810. doi:10.1038/emboj.2012.27

About the lab


Cancer Research UK

Research Themes

Regulation of transcription
Signalling pathways


Light microscopy
Translational research
Super-resolution microscopy
Electron microscopy


Cosetta Bertoli (Postdoctoral Fellow)
Elena Ledesma (Postdoctoral Fellow)
Bisjawit Podder (Postdoctoral Fellow)
Silvia Peripolli (PhD Student)
Joe Jones (PhD Student)
Leticia Meneguello (PhD Student)
Koshiro Kiso (PhD Student)
Karla Vuina (PhD Student)


Buzz Baum (LMCB, UK)
Eva Paluch (LMCB. UK)
Janos Kriston-Vizi (LMCB, UK)
Jurg Bahler (UCL, UK)
Ravi Gupta (UCL, UK)
Marc Mansour (UCL, UK)
Paul Russell (The Scripps Research Institute, USA)
Marcus Smolka (Cornell University, USA)
Amir Aharoni (Negev University, Israel)
Nick Buchler (Duke University, USA)