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LMCB - MRC Laboratory for Molecular Cell Biology

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Rob De Bruin's picture
LMCB Group Leader, UCL Professor of Molecular Cancer Biology
Vice Dean (EDI), Faculty of Life Sciences 
 
+44 (0)20 7679 7255
LMCB Room B101
 
Cell cycle regulated transcription and genome integrity

Research synopsis

The de Bruin lab focuses on two main lines of investigation: (1) elucidating the mechanism and functional importance of the regulation of the cell cycle transcriptional program by the checkpoints that ensure maintenance of genome integrity, and (2) obtaining a better understanding of fundamental regulatory pathways that cause changes in cell cycle-regulated gene expression and the importance of this regulation for the maintenance of genome integrity.

Our work is aimed at understanding, at the molecular level, why defects in proteins ranging from gene-specific transcriptional regulators to global regulators of transcription are associated with human disease, most notably with cancer.

de Bruin lab research image

de Bruin lab research image

About the lab

Funders

Cancer Research UK

Research themes

Regulation of transcription
Signalling pathways
 

Technology

Light microscopy
Translational research
Bioinformatics
Super-resolution microscopy
Electron microscopy
 

People

Cosetta Bertoli (Postdoctoral Fellow)
Elena Ledesma (Postdoctoral Fellow)
Bisjawit Podder (Postdoctoral Fellow)
Leticia Meneguello (PhD Student)
Koshiro Kiso (PhD Student)
Karla Vuina (PhD Student)
 

Collaborators

Janos Kriston-Vizi (LMCB, UK)
Jurg Bahler (UCL, UK)
Ravi Gupta (UCL, UK)
Marc Mansour (UCL, UK)
Buzz Baum (MRC LMB, UK)
Eva Paluch (Cambridge University, UK)
Paul Russell (The Scripps Research Institute, USA)
Marcus Smolka (Cornell University, USA)
Amir Aharoni (Negev University, Israel)
Nick Buchler (Duke University, USA)