Research Synopsis


Selected Publications
Lopes da Silva M & Cutler DF (2016). Von Willebrand Factor multimerization and the polarity of secretory pathways in endothelial cells. Blood.
Ferraro F, et al (2016). Weibel-Palade body size modulates the adhesive activity of its von Willebrand Factor cargo in cultured endothelial cells. SCIENTIFIC REPORTS, 6, ARTN 32473. doi:10.1038/srep32473
Westmoreland D, et al (2016). Super-resolution microscopy as a potential approach to diagnosis of platelet granule disorders. Journal of thrombosis and haemostasis : JTH, 14 (4), 839-849.
Ferraro F, et al (2014). A two-tier Golgi-based control of organelle size underpins the functional plasticity of endothelial cells. Dev Cell, 29 (3), 292-304. doi:10.1016/j.devcel.2014.03.021
Doyle EL, et al (2011). CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. Blood, 118 (15), 4265-4273. doi:10.1182/blood-2010-11-321489
Nightingale TD, et al (2011). Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosis. J Cell Biol, 194 (4), 613-629. doi:10.1083/jcb.201011119
About the lab
Funders
Medical Research Council
British Heart Foundation
Research Themes
Polarity and cell shape, Cytoskeleton and cell cortex, Organelle biogenesis, Endothelial cells, Platelets, Haemostasis, Membrane trafficking, Inflammation
Technology
Light microscopy, Translational research, Bioinformatics, Super-resolution microscopy, Electron microscopy
People
Kimberley Harrison-Lavoie (Research Assistant)
Jessica McCormack (Postdoctoral Fellow)
Francesca Patella (Postdoctoral Fellow)
Collaborators
Louise Cramer (LMCB, UK)
Paul Gissen (LMCB, UK)
Robin Ketteler (LMCB, UK)
Janos Kriston-Vizi (LMCB, UK)
Karen Page (UCL, UK)
Anna Randi (Imperial College, UK)
Tom Nightingale (QMUL, UK)