LMCB - Laboratory for Molecular Cell Biology

Robin Ketteler's picture
LMCB Group Leader, UCL Professor of Translational Cell Biology
Professor of Biochemistry, Medical School Berlin
Cell signalling and autophagy

Research synopsis

In every cell, growth, proliferation and survival are key processes that require tight regulation by signal transduction pathways. Defects in this regulatory control can lead to severe diseases, such as cancer.

Cells maintain a balance of growth and survival by two main processes: Growth factor signalling (under nutrient-rich conditions) and autophagy (under nutrient-scarce conditions). Over the past years, it has become clear that these processes are tightly co-regulated.

In my lab we aim to elucidate the molecular interactions between these pathways. We use systematic genomic approaches to identify networks of cell signalling and autophagy. We employ high-throughput screening technologies as a means to identify novel components that modify cellular signal transduction pathways and autophagy. To this end, we are developing novel screening technologies based on arrayed CRISPR libraries and using knockout cell panels.

Our studies will generate strategies for the identification of potential therapeutic targets in diseases such as cancer and neuro-degeneration. Further, we have the resources and expertise to translate these basic research findings into a drug discovery program to identify potential therapeutic lead compounds.

Ketteler lab research imageKetteler lab research image

Selected publications

Malod-Dognin N, et al (2019). Towards a data-integrated cell. Nat Commun. 2019 Feb 18;10(1):805. doi:10.1038/s41467-019-08797-8. Erratum in: Nat Commun. 2019 May 21;10(1):2324.
Frampton D, et al (2018). Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor. Cancer Cell. Apr 9;33(4):620-633.e6. 
Petschnigg J, et al (2016). Systematic Identification of Oncogenic EGFR Interaction Partners. J Mol Biol. Jan 20;429(2):280-294. 
Yao Z, et al (2015). Application guide for omics approaches to cell signaling. Nat Chem Biol. Jun;11(6)387-97. 

About the lab


Medical Research Council
Pancreatic Cancer UK
UCL-Eisai collaboration

Research themes

Signalling pathways
Electron microscopy


Light microscopy
Electron microscopy
Translational research
High-throughput screening
High content screening
Genome editing, siRNA
Expression cloning


Christin Luft (PDRA)
Denise Bairros de Pilger (PDRA)


Dan Cutler (LMCB, UK)
Mark Marsh (LMCB, UK)
Chris Stefan, (LMCB, UK)
Paul Gissen (ICH, UCL, UK)
Tom Warner (UCL, UK)
Manju Kuryian (UCL, UK)
Anisur Rahman (UCL, UK)
Natasa Przulj (UCL, UK)
Jason Mercer (Birmingham University, UK)
Ricardo Henriques (IGC, Portugal)
Igor Stagljar (University of Toronto, Canada)