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LMCB - MRC Laboratory for Molecular Cell Biology

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Robin Ketteler's picture
LMCB Group Leader, UCL Professor of Translational Cell Biology, High Content Biology Leader
 
+44 (0)20 7679 4063
LMCB Room 2.03
 
Cell Signalling and Autophagy

Research Synopsis

In every cell, growth, proliferation and survival are key processes that require tight regulation by signal transduction pathways. Defects in this regulatory control can lead to severe diseases, such as cancer.

Cells maintain a balance of growth and survival by two main processes: Growth factor signalling (under nutrient-rich conditions) and autophagy (under nutrient-scarce conditions). Over the past years, it has become clear that these processes are tightly co-regulated.

In my lab we aim to elucidate the molecular interactions between these pathways. We use systematic genomic approaches to identify networks of cell signalling and autophagy. We employ high-throughput screening technologies as a means to identify novel components that modify cellular signal transduction pathways and autophagy. To this end, we are developing novel screening technologies based on arrayed CRISPR libraries and using knockout cell panels.

Our studies will generate strategies for the identification of potential therapeutic targets in diseases such as cancer and neuro-degeneration. Further, we have the resources and expertise to translate these basic research findings into a drug discovery program to identify potential therapeutic lead compounds.

Ketteler lab research image

Ketteler lab research image

Selected Publications

10.1074/jbc.AC119.009977. Epub  Jul 17. PubMed PMID: 31315929; PubMed Central PMCID: PMC6709618.
Malod-Dognin N, et al (2019). Towards a data-integrated cell. Nat Commun. 2019 Feb 18;10(1):805. doi:10.1038/s41467-019-08797-8. Erratum in: Nat Commun. 2019 May 21;10(1):2324. PubMed PMID: 30778056; PubMed Central PMCID: PMC6379402.
Agrotis A, et al (2019). Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells. Autophagy. Jun;15(6):976-997. doi: 10.1080/15548627.2019.1569925. Epub 2019 Feb 1.
Frampton D, et al (2018). Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor. Cancer Cell. Apr 9;33(4):620-633.e6. doi:10.1016/j.ccell.2018.03.003.
Pengo N, et al (2017). A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B. Nat Comm. Aug 18;8(1):294. doi:10.1038/s41467-017-00303-2.
Petschnigg J, et al (2016). Systematic Identification of Oncogenic EGFR Interaction Partners. J Mol Biol. Jan 20;429(2):280-294. doi:10.1016/j.jmb.2016.12.006.
Yao Z, et al (2015). Application guide for omics approaches to cell signaling. Nat Chem Biol. Jun;11(6)387-97. doi:10.1038/nchembio.1809. 
 
 

About the lab

Funders

Medical Research Council
Action Medical Research
BBSRC

Research Themes

Signalling pathways, Electron microscopy

Technology

Light microscopy, Electron microscopy, Translational research, Bioinformatics, High-throughput screening, High content screening, Genome editing, siRNA, Expression cloning

People

Christin Luft (Postdoctoral Fellow)
Denise Pilger (Postdoctoral Fellow)
Eliona Tsefou (Postdoctoral Fellow)
Nivedita Singh (Postdoctoral Fellow)
Tasha Aley (PhD student)
 
 

Collaborators

Paul Gissen (LMCB, UK)
Dan Cutler (LMCB, UK)
Mark Marsh (LMCB, UK)
Chris Stefan, (LMCB, UK)
Jason Mercer (LMCB, UK)
Ricardo Henriques (LMCB, UK)
Tom Warner (UCL, UK)
Manju Kuryian (UCL, UK)
Anisur Rahman (UCL, UK)
Natasa Przulj (UCL, UK)
Igor Stagljar (University of Toronto, Canada)