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LMCB - MRC Laboratory for Molecular Cell Biology

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Andela Saric's picture

UCL Associate Professor of Biological and Soft Matter Physics

a.saric@ucl.ac.uk
+44 (0)20 7679 4466
LMCB Room 2.01

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Twitter @SaricLab

Computational Physical Biology

Research Synopsis

We are an interdisciplinary and interactive research group based in UCL LMCB and Department of Physics and Astronomy. We bring together ideas and tools from theoretical and computational physics and chemistry to develop fundamental understanding behind complex life processes.  
Our research is centered around protein assembly in life and disease: how proteins create the macromolecular machinery of life, and how pathological protein aggregation involved in neurodegenerative disease occurs. We are particularly focused on cell reshaping and cutting by ESCRT filaments, protein assembly under chemical and mechanical gradients, and pathological amyloid aggregation. We develop minimal computer models, in a close collaboration with experimental colleagues, to explain and predict the molecular steps involved in these complex phenomena.
 

Selected Publications

Funders

Wellcome Trust
European Research Council
Royal Society
EPSRC
Academy of Medical Sciences
Volkswagen Foundation
 

Research Themes

Cytoskeleton
Polarity and cell shape
Membrane trafficking
Protein aggregation
Membrane remodelling
 

Technology

Biophysics
Computational biology
 

People

Johannes Krausser (Postdoc)
Ivan Palaia (Postdoc)
Xiuyun Sharon Jiang (Postdoc)
Alexandru Paraschiv (PhD student)
Lena Harker-Kirschneck (PhD student)
Joel Forster (PhD student)
Samo Curk (PhD student)
Christian Vanhille Campos (PhD student)
Miguel Amaral (PhD student)
Kevin Klein (PhD student)
 

Collaborators

Buzz Baum (LMCB, UK; LMB Cambridge, UK)
Yanlan Mao (LMCB, UK)
Bart Hoogenboom (UCL LCN, UK)
Ricardo Henriques (LMCB, UK; IGC, Portugal)
Tuomas Knowles (University of Cambridge, UK)
Aurelién Roux (University of Geneva, Switzerland)
Daan Frenkel (University of Cambridge, UK)
Patricia Bassereau (Institute Curie, France)
Xiaolei Xu (Yale University, USA)
Teuta Pilizota (University of Edinburgh)