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LMCB - MRC Laboratory for Molecular Cell Biology

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Franck Pichaud's picture
LMCB Group Leader, UCL Professor of Cell and Developmental Biology
 
+44 (0)20 7679 7817
LMCB Room 3.12
 
Twitter @PichaudLab
Polarity and Morphogenesis

Research Synopsis

The central aim of the Pichaud lab is to characterize the genetic, cellular and molecular bases of cell morphogenesis and polarity during development.

Polarity underpins the function of many cell types, developmental processes and organs. The polarized specialization of the cell cortex and plasma membrane enables epithelial cells to form sheets during organogenesis, neural circuit formation and asymmetric cell division as well as directed cell migration. 

Elucidating how cell polarity arises, is maintained or remodeled during development is a major step toward understanding organogenesis, and a wide range of congenital disorders and pathologies such as cancer and neurodevelopmental diseases.

Pichaud lab research image

Pichaud lab research image

Selected Publications

Pichaud F, et al (2019). Regulation of Cdc42 and its effectors in epithelial morphogenesis. Journal of Cell Science 132: jcs217869.
Zihni C, et al (2017). An apical MRCK-driven morphogenetic pathway controls epithelial polarity. Nature Cell Biology 19, 1049-1060.
Walther RF, et al (2016). Pak4 Is Required during Epithelial Polarity Remodeling through Regulating AJ Stability and Bazooka Retention at the ZA. CELL REPORTS, 15 (1), 45-53. doi:10.1016/j.celrep.2016.03.014

 

About the lab

Funders

Medical Research Council
Wellcome Trust
BBSRC
 

Research Themes

Cytoskeleton and cell cortex, Polarity and cell shape, Cell-cell interactions, Membrane trafficking

Technology

Light microscopy, Translational research, Bioinformatics,  Super-resolution microscopy, Electron microscopy

People

Rhian Walther (Investigator Scientist)
Chiara Mencarelli (Postdoctoral Fellow)
Kate Massey (PhD Student)
Jak Sheeran (Masters Student)

Collaborators

Buzz Baum (LMCB, UK)
Chris Stefan (LMCB, UK)
Yanlan Mao (LMCB, UK)
Ricardo Henrique (LMCB, UK)
Shila Banerjee (UCL, UK)
Roberto Mayor (UCL, UK)
Karl Matter (UCL, UK)
Francois Schweisguth (Institut Pasteur, France)