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LMCB - MRC Laboratory for Molecular Cell Biology

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Ricardo Henriques's picture

LMCB Group Leader, UCL Senior Lecturer, Experimental Optics Leader

r.henriques@ucl.ac.uk
+44 (0)20 7679 7936
LMCB Room 4.13

 

Quantitative Imaging and Nanobiophysics

Research Synopsis

The Henriques lab was established in 2013 to undertake research combining cell biology, optical physics and biochemistry. The group focuses on biological problems that cannot be addressed with current imaging technology, and thus aims to develop analytical, optical and biochemical approaches to address these questions.

In cell biology we aim to understand how viruses enter cells by probing and remodelling membranes, and what are the structural changes viruses undergo during cell-entry, uncoating and morphogenesis. To do so, we are developing new classes of fluorescent probes, high-speed cell friendly Super-Resolution (SR) methods and computational modelling approaches that, although designed to answer questions of interest in the lab, will have broad applications in cell biology research.

 

Selected Publications

Laine RF, et al (2019). NanoJ: a high-performance open-source super-resolution microscopy toolbox. J. Phys. D. doi.org/10.1088/1361-6463/ab0261
Culley S, et al (2018). Quantitative mapping and minimization of super-resolution optical imaging artifacts. Nat. Methods. doi.org/10.1038/nmeth.4605
Culley S, et al (2018). SRRF: Universal live-cell super-resolution microscopy. Int. J. Biochem. Cell Biol. doi.org/10.1016/j.biocel.2018.05.014
Gray RDM, et al (2016). VirusMapper: Open-source nanoscale mapping of viral architecture through super-resolution microscopy. Scientific Reports, 6. doi:10.1038/srep29132
Gustafsson N, et al (2016). Fast live-cell conventional fluorophore nanoscopy with ImageJ through super-resolution radial fluctuations. Nature Communications, 7. doi:10.1038/ncomms12471
Henriques R, et al (2010). QuickPALM: 3D real-time photoactivation nanoscopy image processing in ImageJ. Nat Methods, 7 (5), 339-340. doi:10.1038/nmeth0510-339
 

About the lab

Funders

Medical Research Council
Wellcome Trust
BBSRC

Research Themes

Cytoskeleton and cell cortex, Signalling pathways, Cell-cell interactions, Membrane trafficking, Viral pathogens, Biophysics, Computational biology

Technology

Light microscopy, Super-resolution microscopy, Translational research, Electron microscopy

People

Siân Culley (Postdoctoral Fellow)
David Albrecht (Postdoctoral Fellow)
Romain Laine (Postdoctoral Fellow)
Kalina Tosheva (PhD Student, MRC-LMCB)
Lucas Von Chamier (PhD Student, MRC-LMCB)
Yue Yuan (PhD Student, BBSRC LiDO)
Tchyn Lang Laure Ho (PhD Student, BBSRC LiDO iCASE)

Collaborators

Mark March (LMCB, UK)
Jason Mercer (LMCB, UK)
Buzz Baum (LMCB, UK)
Christophe Leterrier (Aix-Marseille Univ, France)
Loïc Royer (CZ-Biohub, USA)
Florian Jug (MPI-CSBD, Dresden, Germany)
Dylan Owen (Birmingham University, UK)
Musa Mhlanga (UCT, South Africa)