Centre for Amyloidosis and Acute Phase Proteins


UKAMPRO Research

Our research focusses on supporting basic and clinical (5-8) research in the Centre, the development of new approaches to optimise amyloid identification and quantitation9 and collaborations with groups both on and off-site (10).

Our large clinical proteomics database (>2500 samples) allows an in-depth analysis of the data. Recent findings:

  • Formalin fixing can result in partial lysine methylation of wild type transthyretin and the misidentification of variant p.V122I (11).
  • Fibrinogen Aa amyloid can be distinguished from thrombus-derived FibAa using variant searches and the relative scores of the b and chains (12).
  • ApoA-IV amyloid is associated with presence of fibrillogenic signal sequence (13)

We are an active member of the European Proteomics Amyloid Network (EPAN), established in London in 2017, aiming to define standard procedures and share experiences on amyloid proteomics and related technologies (14).

For collaborative studies, including amyloid fibril extraction, 1D gel analysis, non-human samples, protein MW analysis, protein purification, PTM analysis and general advice please contact: Dr Diana Canetti, d.canetti@ucl.ac.uk; diana.canetti@nhs.net