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Our research focusses on supporting basic and clinical (5-8) research in the Centre, the development of new approaches to optimise amyloid identification and quantitation9 and collaborations with groups both on and off-site (10).
Our large clinical proteomics database (>2500 samples) allows an in-depth analysis of the data. Recent findings:
- Formalin fixing can result in partial lysine methylation of wild type transthyretin and the misidentification of variant p.V122I (11).
- Fibrinogen Aa amyloid can be distinguished from thrombus-derived FibAa using variant searches and the relative scores of the b and g chains (12).
- ApoA-IV amyloid is associated with presence of fibrillogenic signal sequence (13)
For collaborative studies, including amyloid fibril extraction, 1D gel analysis, non-human samples, protein MW analysis, protein purification, PTM analysis and general advice please contact: Dr Diana Canetti, d.canetti@ucl.ac.uk; diana.canetti@nhs.net
