Collaborations

Dr Leo James

MRC Laboratory of Molecular Biology, Cambridge

Leo is a biophysicist and crystallographer with whom we take a structure function approach to our favourite biological questions.

Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC. HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis. Nature. 2016 Aug 18;536(7616):349-53. Epub 2016 Aug 10.

Rasaiyaah, J., C. P. Tan, A. J. Fletcher, A. J. Price, C. Blondeau, L. Hilditch, D. A. Jacques, D. L. Selwood, L. C. James, M. Noursadeghi and G. J. Towers. 2013. HIV-1 evades innate immune recognition through specific co-factor recruitment. Nature (2013) doi:10.1038/nature12769

Bichel, K., A. J. Price, T. Schaller, G. J. Towers, S. M. Freund, and L. C. James. 2013. HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358. Retrovirology 10:81.

Price, A. J., A. J. Fletcher, T. Schaller, T. Elliot, K. Lee, V. N. Kewalramani, J. Chin, G. J. Towers, and L. C. James. 2012. CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. PLoS pathogens 8:e1002896

Caines, M. E., K. Bichel, A. J. Price, W. A. McEwan, G. J. Towers, B. J. Willett, S. M. Freund, and L. C. James. 2012. Diverse HIV viruses are targeted by a conformationally dynamic antiviral. Nat Struct Mol Biol 19:411-416.

Ylinen, L. M., Price, A. J., Rasaiyaah, J., Hue, S., Rose, N. J., Marzetta, F., James, L. C. & Towers, G. J. 2010. Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity. PLoS Pathogens 6: e1001062

Mallery, D. L., W. A. McEwan, S. R. Bidgood, G. J. Towers, C. M. Johnson, and L. C. James. 2010. Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21). Proceedings of the National Academy of Sciences of the United States of America 107:19985-19990.

Price, A. J., F. Marzetta, M. Lammers, L. M. J. Ylinen, T. Schaller, S. J. Wilson, G. J. Towers and L. C. James. 2009. Active site remodelling switches HIV specificity of antiretroviral TRIMCyp. Nature Struct Mol Biol 16: 1036-42

Dr Mahdad Noursadeghi

Division of Infection and Immunity, UCL

We collaborate with Maddy to understand how HIV-1 interacts with the innate immune system. Maddy helped us set up replication experiments in primary monocyte derived macrophages. Plus Maddy owns a speedboat.

Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK. Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages. Retrovirology. 2014 Mar 21;11:25. doi: 10.1186/1742-4690-11-25.

Towers GJ, Noursadeghi M. Interactions between HIV-1 and the cell-autonomous innate immune system. Cell Host Microbe. 2014 Jul 9;16(1):10-8. doi: 10.1016/j.chom.2014.06.009.

Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK. Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages. Retrovirology. 2014 Mar 21;11:25. doi: 10.1186/1742-4690-11-25.

Rasaiyaah, J., C. P. Tan, A. J. Fletcher, A. J. Price, C. Blondeau, L. Hilditch, D. A. Jacques, D. L. Selwood, L. C. James, M. Noursadeghi and G. J. Towers. 2013. HIV-1 evades innate immune recognition through specific co-factor recruitment. Nature (2013) doi:10.1038/nature12769

Hughes R, Towers G, Noursadeghi M. Innate immune interferon responses to human immunodeficiency virus-1 infection. Rev Med Virol. 2012 Jul;22(4):257-66. doi: 10.1002/rmv.1708. Epub 2012 Feb 22. Review.

Tomlinson, G. S., H. Booth, S. J. Petit, E. Potton, G. J. Towers, R. F. Miller, B. M. Chain, and M. Noursadeghi. 2012. Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation. PloS one 7:e40348.

Schaller, T., K. E. Ocwieja, J. Rasaiyaah, A. J. Price, T. L. Brady, S. L. Roth, S. Hue, A. J. Fletcher, K. Lee, V. N. Kewalramani, M. Noursadeghi, R. G. Jenner, L. C. James, F. D. Bushman, and G. J. Towers. 2011. HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency. PLoS Pathog 7:e1002439

Tsang, J., B. M. Chain, R. F. Miller, B. L. J. Webb, W. Barclay, G. J. Towers, D. R. Katz, and M. Noursadeghi. 2009. HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation. AIDS 23:2255-63

Ylinen LM, Schaller T, Price A, Fletcher AJ, Noursadeghi M, James LC, Towers GJ. Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D. J Virol. 2009 Feb;83(4):2044-7. doi: 10.1128/JVI.01876-08. Epub 2008 Dec 10.

Dr Stéphane Hué

Department of Infectious Disease Epidemiology, LSHTM

We collaborate with Stéphane to consider the genetics of host and virus using phylogenetic and positive selection techniques.

Monit C, Goldstein RA, Towers G, Hué S. Positive Selection Analysis of Overlapping Reading Frames Is Invalid. AIDS Res Hum Retroviruses. 2015 Oct;31(10):947. doi: 10.1089/AID.2015.0150. Epub 2015 Jul 22.

Schaller, T., K. E. Ocwieja, J. Rasaiyaah, A. J. Price, T. L. Brady, S. L. Roth, S. Hue, A. J. Fletcher, K. Lee, V. N. Kewalramani, M. Noursadeghi, R. G. Jenner, L. C. James, F. D. Bushman, and G. J. Towers. 2011. HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency. PLoS Pathog 7:e1002439

Gupta, K. R., S. Hué, T. Schaller, E. Verschoor, D. Pillay and G. J. Towers. 2009. Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion. PloS Pathogens 5:e1000443

Ylinen, L. M., Price, A. J., Rasaiyaah, J., Hue, S., Rose, N. J., Marzetta, F., James, L. C. & Towers, G. J. 2010. Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity. PLoS Pathogens 6: e1001062

Fletcher AJ, Hué S, Schaller T, Pillay D, Towers GJ. Hare TRIM5α restricts divergent retroviruses and exhibits significant sequence variation from closely related lagomorpha TRIM5 genes. J Virol. 2010 Dec;84(23):12463-8. doi: 10.1128/JVI.01514-10. Epub 2010 Sep 22.

Hué S, Gray ER, Gall A, Katzourakis A, Tan CP, Houldcroft CJ, McLaren S, Pillay D, Futreal A, Garson JA, Pybus OG, Kellam P, Towers GJ. Disease-associated XMRV sequences are consistent with laboratory contamination. Retrovirology. 2010 Dec 20;7(1):111. doi: 10.1186/1742-4690-7-111.

Katzourakis A, Hué S, Kellam P, Towers GJ. Phylogenetic analysis of murine leukemia virus sequences from longitudinally sampled chronic fatigue syndrome patients suggests PCR contamination rather than viral evolution. J Virol. 2011 Oct;85(20):10909-13. doi: 10.1128/JVI.00827-11. Epub 2011 Aug 17.

Schaller T, Hué S, Towers GJ. An active TRIM5 protein in rabbits indicates a common antiviral ancestor for mammalian TRIM5 proteins. J Virol. 2007 Nov;81(21):11713-21. Epub 2007 Aug 29.

Dr Ravi Gupta

Division of Infection and Immunity, UCL

Ravi is a clinical Virologist and Wellcome Trust Intermediate Clinical Fellow. Ravi is interested in how host virus interactions influence disease outcome in patients.

Mlcochova P, Caswell SJ, Taylor IA, Towers GJ, Gupta RK. DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages. EMBO J. 2018 Jan 4;37(1):50-62. doi: 10.15252/embj.201796880. Epub 2017 Oct 30.

Mlcochova P, Sutherland KA, Watters SA, Bertoli C, de Bruin RA, Rehwinkel J, Neil SJ, Lenzi GM, Kim B, Khwaja A, Gage MC, Georgiou C, Chittka A, Yona S, Noursadeghi M, Towers GJ, Gupta RK. A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages. EMBO J. 2017 Mar 1;36(5):604-616. doi: 10.15252/embj.201696025. Epub 2017 Jan 25.

Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK. Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages. Retrovirology. 2014 Mar 21;11:25. doi: 10.1186/1742-4690-11-25.

Gupta, R. K., Kohli, A., McCormick, A. L., Towers, G. J., Pillay, D.,and C. M. Parry. 2010. Full length HIV-1 Gag determines protease inhibitor susceptibility within in vitro assays. AIDS 24:1651-5

Gupta, R. K. and G. J. Towers. 2009. A tail of tetherin: How pandemic HIV-1 conquered the world. Cell Host and Microbes 5: 393-5

Gupta, K. R., S. Hué, T. Schaller, E. Verschoor, D. Pillay and G. J. Towers. 2009. Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion. PloS Pathogens 5:e1000443

Gupta, R. K., P. Mlcochova, A. Pelchen-Matthews, S. J. Petit, G. Mattiuzzo, D. Pillay, Y. Takeuchi, M. Marsh, and G. J. Towers. 2009. Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration. Proc Natl Acad Sci U S A 106: 20889-20894

Dr Neil Berry

Division of virology, NIBSC

We collaborate with Neil and his colleagues at the National Institute for Biological Standards, part of the MHRA, to understand the correlates of protection of live attenuated vaccination of non-human primates with simian immunodeficiency virus. Neil has found that a live attenuated vaccine provides particularly effective protection from homologous and heterologous lentivirus challenge. Our work has considered the role of restriction factors and the innate immune system generally in protection with the view to developing an HIV-1 vaccine that produces a similar protective response.

Ferguson D, Mattiuzzo G, Ham C, Stebbings R, Li B, Rose NJ, Mee ET, Smith D, Page M, Cranage MP, Almond N, Towers GJ, Berry NJ. Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues. PLoS One. 2014 Aug 27;9(8):e104390. doi: 10.1371/journal.pone.0104390. eCollection 2014.

Mattiuzzo G, Rose NJ, Almond N, Towers GJ, Berry N. Upregulation of TRIM5α gene expression after live-attenuated simian immunodeficiency virus vaccination in Mauritian cynomolgus macaques, but TRIM5α genotype has no impact on virus acquisition or vaccination outcome. Gen Virol. 2013 Mar;94(Pt 3):606-11. doi: 10.1099/vir.0.047795-0. Epub 2012 Nov 14.

Berry NJ, Marzetta F, Towers GJ, Rose NJ. Diversity of TRIM5α and TRIMCyp sequences in cynomolgus macaques from different geographical origins. Immunogenetics. 2012 Apr;64(4):267-78. doi: 10.1007/s00251-011-0585-x. Epub 2011 Nov 29.

Berry N, Ham C, Mee ET, Rose NJ, Mattiuzzo G, Jenkins A, Page M, Elsley W, Robinson M, Smith D, Ferguson D, Towers G, Almond N, Stebbings R. Early potent protection against heterologous SIVsmE660 challenge following live attenuated SIV vaccination in Mauritian cynomolgus macaques. PLoS One. 2011;6(8):e23092. doi: 10.1371/journal.pone.0023092. Epub 2011 Aug 10.

Prof David Selwood

Wolfson Institute for Biomedical Research, UCL

Dave is a medicinal chemist with a focus on cyclosporines. We collaborate with Dave to develop non immunosuppressive analogues of Cyclosporine that might be used as inhibitors of HIV-1 replication. These molecules are also useful tools for the study of primate lentiviral biology.

Culley S, Towers GJ, Selwood DL, Henriques R, Grove J. Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy. Viruses. 2016 Jul 21;8(7). pii: E201. doi: 10.3390/v8070201.

Warne J, Pryce G, Hill JM, Shi X, Lennerås F, Puentes F, Kip M, Hilditch L, Walker P, Simone MI, Chan AW, Towers GJ, Coker AR, Duchen MR, Szabadkai G, Baker D, Selwood DL. Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis. J Biol Chem. 2016 Feb 26;291(9):4356-73. doi: 10.1074/jbc.M115.700385. Epub 2015 Dec 17.

Rasaiyaah, J., C. P. Tan, A. J. Fletcher, A. J. Price, C. Blondeau, L. Hilditch, D. A. Jacques, D. L. Selwood, L. C. James, M. Noursadeghi and G. J. Towers. 2013. HIV-1 evades innate immune recognition through specific co-factor recruitment. Nature (2013) doi:10.1038/nature12769

Dr Julia García Prado

IrsiCaixa, Institut de Reserca de la Sida, Barcelona

We collaborate with Julia to understand the biology of HIV antigen presentation and antiviral mechanisms of TRIM5.

Jimenez-Moyano E, Ruiz A, Kløverpris HN, Rodriguez-Plata MT, Peña R, Blondeau C, Selwood DL, Izquierdo-Useros N, Moris A, Clotet B, Goulder P, Towers GJ, Prado JG. Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8+ T Cells. J Virol. 2016 Sep 12;90(19):8552-62. doi: 10.1128/JVI.00819-16. Print 2016 Oct 1.

Kløverpris HN, Payne RP, Sacha JB, Rasaiyaah JT, Chen F, Takiguchi M, Yang OO, Towers GJ, Goulder P, Prado JG. 2013. Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells. Journal of Virology 87(5):2628-38

Prof Richard Milne

Department of Virology, UCL Medical School

Richard leads infection and immunity teaching at UCL and is recipient of numerous teaching awards. Together with Greg and the Towers lab, he is developing a research-led teaching programme in which senior investigators and post-docs teach undergraduate lectures based on their most recent and exciting discoveries. We aim not only to teach science facts but also to teach students how to think like scientists. Richard and Greg run a London-wide monthly seminar programme: Virtual Virology, and a public engagement programme for school children.

Sumner RP, Thorne LG, Fink DL, Khan H, Milne RS, Towers GJ. Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission? Front Immunol. 2017 Oct 6;8:1246. doi: 10.3389/fimmu.2017.01246. eCollection 2017.

Blondeau, C., A. Pelchen-Matthews, P. Mlcochova, M. Marsh, R. S. Milne, and G. J. Towers. Tetherin Restricts Herpes Simplex Virus Type 1 and is Antagonised by Glycoprotein J.Virol. 2013 Sep 25

Dr Joe Grove

Division of Infection and Immunity, UCL

Joe works on Hepatitis C virus. We collaborate with Joe on novel antivirals that inhibits a range of flaviviruses. We also greatly value Joe's expertise in cell biology and light microscopy and his contributions to our lab meetings.

Siân Culley, Greg J Towers, David L Selwood, Ricardo Henriques, Joe Grove Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy Viruses 2016 Jul 21;8(7):201. doi: 10.3390/v8070201.

Prof Richard Goldstein

Division of Infection and Immunity, UCL

Richard is an computational biologist in our Dept at UCL who studies virus and host evolution. We believe that biological data make most sense when considered in the context of evolution. In collaboration with Richard we consider ways to ask questions that combine evolutionary and molecular biology experimental approaches.

Monit C, Goldstein RA, Towers G, Hué S. Positive Selection Analysis of Overlapping Reading Frames Is Invalid. AIDS Res Hum Retroviruses. 2015 Oct;31(10):947. doi: 10.1089/AID.2015.0150. Epub 2015 Jul 22.

Dr Carlos Maluquer de Motes

University Of Surrey

Carlos studies pox viruses in his group at the University of Surrey. We collaborate with Carlos because pox viruses manipulate DNA sensing and comparing and contrasting replication and innate immune evasion strategies between pox viruses and retroviruses is very informative.

Georgana I, Sumner RP, Towers GJ, Maluquer de Motes C. Virulent poxviruses inhibit DNA sensing by preventing STING activation. J Virol. 2018 Feb 28. pii: JVI.02145-17. doi: 10.1128/JVI.02145-17.

Dr Clare Jolly

Division of Infection and Immunity, UCL

Clare is a cell biologist aiming to understand how HIV-1 transmits from one cell to another. We share lab meetings with Clare and Clare's group have a big input on interpretation of observations made in the lab. We find having more than one PI in the lab meeting is really helpful for discussion and interpretation of new data.

Dr Michela Mazzon

Virology Research Services Ltd

Dr Waseem Qasim

ICH and Great Ormond Street Hospital

We collaborate with Waseem on developing novel gene therapy based approaches to treat HIV infection in children.

Chan E, Towers GJ, Qasim W. Gene therapy strategies to exploit TRIM derived restriction factors against HIV-1. Viruses. 2014 Jan 14;6(1):243-63. doi: 10.3390/v6010243. Review.

Chan, E., T. Schaller, A. Eddaoudi, H. Zhan, C. P. Tan, M. Jacobsen, A. J. Thrasher, G. J. Towers, and W. Qasim. 2012. Lentiviral Gene Therapy Against Human Immunodeficiency Virus Type 1, Using a Novel Human TRIM21-Cyclophilin A Restriction Factor. Human gene therapy. 23:1176-85

Dr David Jacques

Faculty of Medicine, University of New South Wales

David is a structural biologist at the University of New South Wales in Australia. We work with David to understand how lentiviral capsids work and how they regulate encapsidated viral DNA synthesis.

Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling. Fletcher AJ, Vaysburd M, Maslen S, Zeng J, Skehel JM, Towers GJ, James LC. Cell Host Microbe. 2018 Dec 12;24(6):761-775.e6. doi: 10.1016/j.chom.2018.10.007. Epub 2018 Nov 29. PMID:30503508.

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis. Mallery DL, Márquez CL, McEwan WA, Dickson CF, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, Böcking T, James LC. Elife. 2018 May 31;7. pii: e35335. doi: 10.7554/eLife.35335. PMID:29848441

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis. Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC. Nature. 2016 Aug 18;536(7616):349-53. Epub 2016 Aug 10. PMID: 27509857

Dr Che Colpitts

Queens University, Ontario, Canada

Che spent three years as a research fellow with us funded by Canadian fellowships and a grant from the UCL/UCLH Biomedical Research Centre. Che taught us how to work on flaviviruses with a focus on Hepatitis C (HCV). Che worked out that if you inhibit HCV with cyclosporines then the antiviral protein PKR is activated to provide activiral acivity via IRF1 published in eLife. Che now helps us understand how innate immunity works against Dengue Virus funded by an MRC project grant co-written with Che. We were sorry to see Che go but very happy to see her success in setting up and funding her own lab at Queens University in Canada.

Colpitts CC, Ridewood S, Schneiderman B, Warne J, Tabata K, Ng CF, Bartenschlager R, Selwood DL, Towers GJ. 2020 Hepatitis C virus exploits cyclophilin A to evade PKR. Elife. Jun 16;9:e52237. doi: 10.7554/eLife.52237.

Dr Rob Gifford

MRC-University of Glasgow Centre for Virus Research (CVR)

Rob is a computational biologist working at CVR. His insight into viral evolution has helped us understand viral protein function and we are now convinced that nothing makes sense unless considered through the lens of evolution.

Dr Steve Gschmeissner

EM photographer

Steve is a photographer who uses a scanning electron microscope to take pictures. We collaborate with Steve by providing infection related samples for him to photograph. Steve's pictures can be seen on his website http://theworldcloseup.com

Prof Nevan Krogan

Quantitative Biosciences Institute (QBI) at the University of California San Francisco (UCSF)

Krogan lab (Mehdi Bouhaddou, Greg Towers, Lorena Zuliani-Alvarez, Nevan krogan), 2022

We have worked closely with Nevan and his team on SARS-CoV-2 since establishing our collaboration through Lorena. We have collaborated to study responses to SARS-CoV-2 infection with Nevan’s lab performing mass spectrometry, RNA sequencing and structural biology.

Jose F Varona, Pedro Landete, Jose A Lopez-Martin, Vicente Estrada, Roger Paredes, Pablo Guisado-Vasco, Lucia Fernandez de Orueta, Miguel Torralba, Jesus Fortun, Roberto Vates, Jose Barberan, Bonaventura Clotet, Julio Ancochea, Daniel Carnevali, Noemi Cabello, Lourdes Porras, Paloma Gijon, Alfonso Monereo, Daniel Abad, Sonia Zuñiga, Isabel Sola, Jordi Rodon, Julia Vergara-Alert, Nuria Izquierdo-Useros, Salvador Fudio, Maria Jose Pontes, Beatriz de Rivas, Patricia Giron de Velasco, Antonio Nieto, Javier Gomez, Pablo Aviles, Rubin Lubomirov, Alvaro Belgrano, Belen Sopesen, Kris M White, Romel Rosales, Soner Yildiz, Ann-Kathrin Reuschl, Lucy G Thorne, Clare Jolly, Greg J Towers, Lorena Zuliani-Alvarez, Mehdi Bouhaddou, Kirsten Obernier, Briana L McGovern, M Luis Rodriguez, Luis Enjuanes, Jose M Fernandez-Sousa, Nevan J Krogan, Jose M Jimeno, Adolfo Garcia-Sastre. Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19. Life Science Alliance 2022 Jan 10;5(4):e202101200. doi: 10.26508/lsa.202101200. Print 2022 Apr.

Lucy G Thorne, Mehdi Bouhaddou, Ann-Kathrin Reuschl, Lorena Zuliani-Alvarez, Ben Polacco, Adrian Pelin, Jyoti Batra, Matthew V X Whelan, Myra Hosmillo, Andrea Fossati, Roberta Ragazzini, Irwin Jungreis, Manisha Ummadi, Ajda Rojc, Jane Turner, Marie L Bischof, Kirsten Obernier, Hannes Braberg, Margaret Soucheray, Alicia Richards, Kuei-Ho Chen, Bhavya Harjai, Danish Memon, Joseph Hiatt, Romel Rosales, Briana L McGovern, Aminu Jahun, Jacqueline M Fabius, Kris White, Ian G Goodfellow, Yasu Takeuchi, Paola Bonfanti, Kevan Shokat, Natalia Jura, Klim Verba, Mahdad Noursadeghi, Pedro Beltrao, Manolis Kellis, Danielle L Swaney, Adolfo García-Sastre, Clare Jolly, Greg J Towers, Nevan J Krogan. Evolution of enhanced innate immune evasion by SARS-CoV-2. Nature, 2022 Feb;602(7897):487-495. doi: 10.1038/s41586-021-04352-y. Epub 2021 Dec 23.

Lucy G Thorne, Mehdi Bouhaddou, Ann-Kathrin Reuschl, Lorena Zuliani-Alvarez, Ben Polacco, Adrian Pelin, Jyoti Batra, Matthew V X Whelan, Manisha Ummadi, Ajda Rojc, Jane Turner, Kirsten Obernier, Hannes Braberg, Margaret Soucheray, Alicia Richards, Kuei-Ho Chen, Bhavya Harjai, Danish Memon, Myra Hosmillo, Joseph Hiatt, Aminu Jahun, Ian G Goodfellow, Jacqueline M Fabius, Kevan Shokat, Natalia Jura, Klim Verba, Mahdad Noursadeghi, Pedro Beltrao, Danielle L Swaney, Adolfo Garcia-Sastre, Clare Jolly, Greg J Towers, Nevan J Krogan. Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant. BioRxiv, 2021 Jun 7;2021.06.06.446826. doi: 10.1101/2021.06.06.446826. Preprint

José F Varona, Pedro Landete, Jose A Lopez-Martin, Vicente Estrada, Roger Paredes, Pablo Guisado-Vasco, Lucía Fernández de Orueta, Miguel Torralba, Jesús Fortún, Roberto Vates, José Barberán, Bonaventura Clotet, Julio Ancochea, Daniel Carnevali, Noemí Cabello, Lourdes Porras, Paloma Gijón, Alfonso Monereo, Daniel Abad, Sonia Zúñiga, Isabel Sola, Jordi Rodon, Nuria Izquierdo-Useros, Salvador Fudio, María José Pontes, Beatriz de Rivas, Patricia Girón de Velasco, Belén Sopesén, Antonio Nieto, Javier Gómez, Pablo Avilés, Rubin Lubomirov, Kris M White, Romel Rosales, Soner Yildiz, Ann-Kathrin Reuschl, Lucy G Thorne, Clare Jolly, Greg J Towers, Lorena Zuliani-Alvarez, Mehdi Bouhaddou, Kirsten Obernier, Luis Enjuanes, Jose M Fernández-Sousa, Plitidepsin – COVID - 19 Study Group; Nevan J Krogan, José M Jimeno, Adolfo García-Sastre. Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization. MedRxiv, 2021 May 25;2021.05.25.21257505. doi: 10.1101/2021.05.25.21257505. Preprint

Ann-Kathrin Reuschl, Lucy G Thorne, Lorena Zuliani-Alvarez, Mehdi Bouhaddou, Kirsten Obernier, Joseph Hiatt, Margaret Soucheray, Jane Turner, Jacqueline M Fabius, Gina T Nguyen, Danielle L Swaney, Romel Rosales, Kris M White Pablo Avilés, Ilsa T Kirby, James E Melnyk, Ying Shi, Ziyang Zhang, Kevan M Shokat, Adolfo García-Sastre, Clare Jolly, Gregory J Towers, Nevan J Krogan. Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant. BioRxiv, 2021 Feb 4;2021.01.24.427991. doi: 10.1101/2021.01.24.427991. Preprint