In utero stem cell treatment for babies with osteogenesis imperfecta
Step 1- Optimising the isolation, expansion and differentiation of human fetal osteoblasts. Optimising the Quasi vivo system and growth of osteoblasts within to form an ‘ex vivo’ bone model.
Step 2- Comparing amniotic fluid stem cells, their conditioned medium and their extracellular vesicles for their effect on bone in the above model.
Dr Pascale Guillot
Great Ormond Street Institute of Child Health