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Stroke Research

Amyloid PET scans of iatrogenic cerebral amyloid angiopathy (CAA)
Susceptibility-weighted MRI of iatrogenic cerebral amyloid angiopathy (CAA)

Researching stroke prevention, treatment and management, and functional recovery after stroke.

Lead:

Professor David Werring

Stroke Research Centre team:

Jonathan Best
Dr Edgar Chan
Schederazade Feerick (CRN Team)
Nina Francia (CRN Team)
Marilena Marinescu (CRN Team Lead)
Riham Muhammad (CRN Team)
Yee-Chin Lee (CRN Team)
Alex Lewis (CRN Team)
Raafiah Mussa
Philip Nash
Sabaa Obarey (CRN Team)
Hatice Ozkan
Larysa Panteleienko
Dr Richard Perry
Georgia Raingold (CRN team)
Dr Robert Simister

Follow us on Twitter: @UCLStrokeRes

Research Goals

  • To understand the underlying mechanisms of cerebrovascular disease, with a focus on neuroimaging
  • To improve acute treatment and secondary prevention of stroke
  • To develop innovative treatments to prevent stroke, targeting both small and large artery diseases
  • To investigate how cerebral small vessel disease relates to intracerebral haemorrhage and vascular cognitive impairment
  • To conduct randomised controlled trials, investigating important questions relevant for clinical practice in stroke.

Funded Research Projects

  • Prevention of hypertensive injury to the brain by intensive treatment: Intracerebral Haemorrhage. Funded by a Stroke Association Priority Programme Grant for Intracerebral Haemorrhage
     
  • Cerebral amyloid angiopathy cohort to characterize the natural history and establish biomarkers relevant to prognosis
     
  • MICON (Microbleeds International Collaborative Network) 
  • PROHIBIT-ICH (Prevention Of Hypertensive Injury to the Brain by Intensive Treatment after IntraCerebral Haemorrhage: a pilot randomized trial of home telemetry-guided treatment)
  • SIGNAL BRC
     
  • OPTIMAS BHF: OPtimal TIMing of Anticoagulation after AF-associated acute ischaemic Stroke: a randomised controlled trial
Recent publications from Stroke Research

2020

Mc Lernon S, Schwarz G, Wilson D, Ambler G, Goodwin R, Shakeshaft C, Cohen H, Yousry T, Salman RAS, Lip GYH, Houlden H, Brown MM, Muir KW, Jäger HR, Terry L, Werring DJ
Association between critical care admission and 6-month functional outcome after spontaneous intracerebral haemorrhage
Journal of the Neurological Sciences 418:15 Nov 2020
https://doi.org/10.1016/j.jns.2020.117141

Almarzouki A, Wilson D, Ambler G, Shakeshaft C, Cohen H, Yousry T, Salman RA-S, Lip GYH, Houlden H, Brown MM, Muir KW, Jäger HR, Werring DJ
Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage.
Sci Rep 10(1):15529 23 Sep 2020
https://doi.org/10.1038/s41598-020-72504-7

Best JG, Barbato C, Ambler G, Du H, Banerjee G, Wilson D, Shakeshaft C, Cohen H, Yousry TA, Salman RA-S, Lip GYH, Houlden H, Brown MM, Muir KW, Jäger HR, Werring DJ, Clinical Relevance of Microbleeds in Stroke (CROMIS-2) collaborators
Association of enlarged perivascular spaces and anticoagulant-related intracranial hemorrhage.
Neurology 15 Sep 2020
DOI: https://doi.org/10.1212/WNL.0000000000010788

Lyndon D, Davagnanam I, Wilson D, Jichi F, Merwick A, Bolsover F, Jager HR, Cipolotti L, Wheeler-Kingshott C, Hughes D, Murphy E, Lachmann R, Werring DJ
MRI-visible perivascular spaces as an imaging biomarker in Fabry disease
Journal of Neurology 19 Oct 2020
https://doi.org/10.1007/s00415-020-10209-7

Bakker MK, van der Spek RAA, van Rheenen W, Morel S, Bourcier R, Hostettler IC, Alg VS, ....Houlden H, ….. Werring DJ, et al
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Nature Genetics 16 Nov 2020
https://doi.org/10.1038/s41588-020-00725-7

Perry RJ, Smith CJ, Roffe C, Simister RJ, Narayanamoorthi S, Marigold R, Willmot M, Dixit A, Hassan A, Quinn T, Ankolekar S, Zhang L, Banerjee S, Ahmed U, Padmanabhan N, Ferdinand P, McGrane F, Banaras A, Marks IH, Werring DJ
Characteristics and outcomes of COVID-19-associated stroke: a UK multicentre case-control study
Journal of Neurology, Neurosurgery and Psychiatry 05 Nov 2020
http://dx.doi.org/10.1136/jnnp-2020-324927

Ulivi L, Kanber B, Prados F, Davagnanam I, Merwick A, Chan E, Williams F, Hughes D, Murphy E, Lachmann RH, Wheeler-Kingshott CAMG, Cipolotti L, Werring DJ
White matter integrity correlates with cognition and disease severity in Fabry disease.
Brain 03 Nov 2020
https://doi.org/10.1093/brain/awaa282

Werring DJ
The STOP-AUST trial: a test for the spot sign in intracerebral haemorrhage
Lancet Neurol 28 Oct 2020
https://doi.org/10.1016/S1474-4422(20)30398-7

Hostettler IC, O'Callaghan B, Bugiardini E, O'Connor E, Vandrovcova J, Davagnanam I, Alg V, Bonner S, Walsh D, Bulters D, Kitchen N, Brown MM, Grieve J, Werring DJ, Houlden H, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators
ANGPTL6 genetic variants are an underlying cause of familial intracranial aneurysms.
Neurology 26 Oct 2020
https://doi.org/10.1212/WNL.0000000000011125

Wardlaw JM, Doubal F, Brown R, Backhouse E, Woodhouse L, Bath P, Quinn TJ, Robinson T, Markus HS, McManus R, O’Brien JT, Werring DJ, Sprigg N, Parry-Jones A, Touyz RM, Williams S, Mah YH, Emsley H
Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol
European Stroke Journal 11 Oct 2020
https://doi.org/10.1177/2396987320953312

Werring DJ, Al-Shahi Salman R
Untangling the natural history of cerebral arteriovenous malformations.
Journal of Neurology, Neurosurgery and Psychiatry 01 Oct 2020
http://dx.doi.org/10.1136/jnnp-2019-322438

Almarzouki A, Wilson D, Ambler G, Shakeshaft C, Cohen H, Yousry T, Salman RA-S, Lip GYH, Houlden H, Brown MM, Muir KW, Jäger HR, Werring DJ
Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage.
Sci Rep 10(1):15529 23 Sep 2020
https://doi.org/10.1038/s41598-020-72504-7

Du H, Pan X, Liu N, Chen J, Chen X, Werring DJ, Ambler G,...... Fujian Medical Team Support Wuhan for COVID-19
The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study.
Respiratory Research 21(1):241 21 Sep 2020
https://doi.org/10.1186/s12931-020-01510-0

Maskery MP, Holscher C, Jones SP, Price CI, Strain WD, Watkins CL, Werring DJ, Emsley HCA
Glucagon like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review.
J Cereb Blood Flow Metab 271678X20952011 20 Sep 2020 https://doi.org/10.1177/0271678X20952011

Yakushiji Y, Tanaka J, Wilson D, Charidimou A, Noguchi T, Kawashima M, Nishihara M, Best J, Ide T, Nagaishi Y, Mizoguchi M, Hara H, Werring DJ
Proportion of intracerebral haemorrhage due to cerebral amyloid angiopathy in the East and West: Comparison between single hospital centres in Japan and the United Kingdom
Journal of the Neurological Sciences 416:15 Sep 2020
https://doi.org/10.1016/j.jns.2020.117037

Best JG, Barbato C, Ambler G, Du H, Banerjee G, Wilson D, Shakeshaft C, Cohen H, Yousry TA, Salman RA-S, Lip GYH, Houlden H, Brown MM, Muir KW, Jäger HR, Werring DJ, Clinical Relevance of Microbleeds in Stroke (CROMIS-2) collaborators
Association of enlarged perivascular spaces and anticoagulant-related intracranial hemorrhage.
Neurology 15 Sep 2020
https://doi.org/10.1212/WNL.0000000000010788

Knol MJ, Lu D, Traylor M, Adams HH, Rafael J Romero J, Smith AV, Fornage M, Hofer E, Liu J, Hostettler IC, Luciano M, …….Werring DJ, Schmidt H, Wardlaw JM, Ikram MA, Seshadri S, Launer LJ, Markus HS, Alzheimer’s Disease Neuroimaging Initiative
Association of common genetic variants with brain microbleeds: A Genome-wide Association Study.
Neurology 10 Sep 2020
https://doi.org/10.1212/WNL.0000000000010852

Murphy SJ, Werring DJ
Stroke: causes and clinical features
Medicine 01 Sep 2020
https://doi.org/10.1016/j.mpmed.2020.06.002

George Ntaios, Patrik Michel, Georgios Georgiopoulos, Yutao Guo, Wencheng Li, Jing Xiong……
David J. Werring, Arvind Chandratheva, Laura Benjamin, Robert Simister, Richard Perry et al
Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry.
Stroke STROKEAHA120031208 Sep 2020
https://doi.org/10.1161/STROKEAHA.120.031208

Ulivi L, Squitieri M, Cohen H, Cowley P, Werring DJ
Cerebral venous thrombosis: a practical guide.
Pract Neurol 29 Aug 2020
10.1136/practneurol-2020-002415

Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, …. Werring DJ, Wilcock D, Wilson MR, Zlokovic BV, Verma A
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy.
Alzheimers Dement (Amst) 12(1):e12053 03 Aug 2020
https://doi.org/10.1002/dad2.12053

Tsivgoulis G, Katsanos AH, Seiffge DJ, Paciaroni M, Wilson D, Koga M, Macha K, Cappellari M, Kallmünzer B, Polymeris AA, Toyoda K, Caso V, Werring DJ, Engelter ST, De Marchis GM, RAF, RAF-DOAC, CROMIS-2, SAMURAI, NOACISP, Erlangen, Verona registry collaborators
Fatal Intracranial Hemorrhage Occurring after Oral Anticoagulant Treatment Initiation for Secondary Stroke Prevention in Patients with Atrial Fibrillation
European Journal of Neurology 01 Aug 2020
https://doi.org/10.1111/ene.14280

Isabel C Hostettler, MD, Menelaos Pavlou, PhD, Gareth Ambler, PhD, Varinder S Alg, MD, Stephen Bonner, FFICM, Daniel C Walsh, FRCS, Diederik Bulters, FRCS, Neil Kitchen, PhD, Martin M Brown, FRCP, Joan Grieve, MD, Henry Houlden, PhD, David J Werring, PhD, FRCP on behalf of the Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators
Assessment of the Subarachnoid Hemorrhage International Trialists (SAHIT) Models for Dichotomized Long-Term Functional Outcome Prediction After Aneurysmal Subarachnoid Hemorrhage in a United Kingdom Multicenter Cohort Study.
Neurosurgery, Volume 87, Issue 6, December 2020, Pages 1269–1276
https://doi.org/10.1093/neuros/nyaa299

Belsten J, Werring DJ, Jones H, Heales S, Pope S
Cerebrospinal fluid folate, ascorbate, and tetrahydrobiopterin deficiency in superficial siderosis: A new potential mechanism of neurological dysfunction?
Journal of the Neurological Sciences 414:15 Jul 2020
https://doi.org/10.1016/j.jns.2020.116856

Thomalla G, Boutitie F, Ma H, Koga M, Ringleb P, Schwamm LH, Wu O….Perry R…
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
The Lancet 396(10262):1574-1584 14 Nov 2020
https://doi.org/10.1016/S0140-6736(20)32163-2

Banerjee G, Chan E, Ambler G, Wilson D, Cipolotti L, Shakeshaft C, Cohen H, Yousry T, Al-Shahi Salman R, Lip GYH, Muir KW, Brown MM, Jäger HR, Werring DJ. Cognitive impairment before atrial fibrillation-related ischemic events: neuroimaging and prognostic associations. Journal of the American Heart Association 2020; 9(1):e014537 DOI: 10.1161/JAHA.119.014537

Banerjee G, Werring DJ. Feasibility of clinical trial recruitment for cerebral amyloid angiopathy: A specialist single centre experience. J Neurol Sc 2020; 409:116580.DOI: 10.1016/j.jns.2019.116580

Banerjee G, Ambler G, Keshavan A, Paterson RW, Foiani MS, Toombs J, Heslegrave A, Dickson JC, Fraioli F, Groves AM, Lunn MP, Fox NC, Zetterberg H, Schott JM, Werring DJ. Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy. Journal of Alzheimer’s Disease, online 1st March 2020.DOI: 10.3233/JAD-191254

Banerjee G, Ambler G, Keshavan A, Paterson RW, Foiani MS, Toombs J, Heslegrave A, Dickson JC, Faioli F, Groves AM, Lunn MP, Fox NC, Zetterberg H, Schott NM, Werring DJ.  Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy.  Journal of Alzheimer’s Disease, online 21st April 2020

Banerjee G, Ambler G, Wilson D, Hostettler IC, Shakeshaft C, Lunawat S, Cohen H, Yousry T, Al-Shahi Salman R, Lip GYH, Houlden H, Muir KW, Brown MM, Jager HR, Werring DJ, CROMIS-2 collaborators.  Baseline factors associated with early and late death in intracerebral haemorrhage survivors.  European Journal of Neurology, online 29th March 2020

Banerjee G, Wilson D, Ambler G, Hostettler IC, Shakeshaft C, Cohen H, Yousry T, Al-Shahi Salman R, Lip GYH, Houlden H, Muir KW, Brown MM, Jager HR, Werring DJ, CROMIS-2 collaborators. Longer term stroke risk in intracerebral haemorrhage survivors.  Journal of Neurology, Neurosurgery & Psychiatry, online 17th June 2020

Belsten J, Werring DJ, Jones H, Heales S, Pope S.  Cerebrospinal fluid folate, ascorbate, and tetrahydrobiopterin deficiency in superficial siderosis:  A new potential mechanism of neurological dysfunction?  Journal of the Neurological Sciences 414: 15th July 2020

Hostettler IC, Morton MJ, Ambler G, Kazmi N, Gaunt T, Wilson D, Shakeshaft C, Jäger HR, Cohen H, Yousry TA, Al-Shahi Salman R, Lip G, Brown MM, Muir K, Houlden H, Bulters DO, Galea I, Werring DJ, CROMIS-2 collaborators. Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage. Journal of Neurology, Neurosurgery and Psychiatry, online 10 January 2020.https://doi.org/10.1136/jnnp-2019-321774

Lim ST, Thijs V, Murphy SJX, Fernandez-Cadenas I, Montaner J, Offiah C, Marquardt L, Kelly PJ, Bath PM, Lim S-Y, Ford GA, Norrving B, Cox D, Prodan CI, Barber PA, Werring DJ, Perry R, Zgaga L, Dawson J, McCabe DJH.  Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke:  systematic review and meta-analysis.  J Neurol, online 9th June 2020

Marrinan E, Chen L, Werring D, Turner D. Reducing delays to administration of prothrombin complex concentrate in patients with vitamin K antagonist-related intracerebral haemorrhage. British Journal of Hospital Medicine 2020;81(2):1-6.DOI: 10.12968/hmed.2020.0007

Morton MJ, Hostettler IC, Kazmi N, Alg VS, Bonner S, Brown MM, Durnford A, Gaastra B, Garland P, Grieve J, Kitchen N, Walsh D, Zolnourian A, Houlden H, Gaunt TR, Bulters DO, Werring DJ, Galea I, Genetics and Observational Subarachnoid Haemorrhage Study investigators. Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage. Journal of Neurology, Neurosurgery and Psychiatry, online 1st March 2020.

Schlemm L, Endres M, Werring DJ, Nolte CH. Benefit of intravenous thrombolysis in acute ischemic stroke patients with high cerebral microbleed burden. Stroke 2020; 51(1):232-239
DOI: 10.1161/STROKEAHA.119.027633

Seiffge DJ, De Marchis GM, Kogg M, Paciaroni M, Wilson D, Cappellari M, Macha MD D, Tsivegoulis G, Ambler G, Arihiro S, Bonati LH, Bonetti B, Kallmünzer B, Muir KW, Bovi P, Gensicke H, Inoue M, Schwab S, Yaghi S, Brown MM, Lyrer P, Takagi M, Acciarrese M, Jäger HR, Polymeris AA, Toyoda K, Venti M,
Traenka C, Yamagami H, Alberti A, Yoshimura S, Caso V, Engelter ST, Werring DJ, RAF, RAF-DOAC, CROMIS-2, SAMURAI, NOACISP, Erlangen and Verona registry collaborators. Ischemic stroke despite oral anticoagulant therapy in patients with atrial fibrillation. Annals of Neurology, online 27 February 2020.

Tsivgoulis G, Katsanos AH, Seiffge DJ, Paciaroni M, Wilson D, Koga M, Macha K, Cappellari M, Kallmunzer B, Polymeris AA, Toyoda K, Caso V, Werring DJ, Engelter ST, De Marchis GM, RAF, RAF-DOAC, CROMIS-2, SAMURAI, NOACISP, Erlangen, Verona registry collaborators.  Fatal intracranial hemorrhage occurring after oral anticoagulant treatment initiation for secondary stroke prevention in patients with atrial fibrillation.  European Journal of Neurology, online 25th April 2020

Wallace AC, Talelli P, Crook L, Austin D, Farrell R, Hoad D, O’Keeffe A, Marsden J, Fitzpatrick R, Greenwood R, Rothwell J, Werring D. Exploratory randomized double-blind placebo controlled trial of botulinum therapy on grasp release after stroke (PrOMBiS). Neurorehabilitation and Neural Repair, online 1st January 2020 https://doi.org/10.1177%2F1545968319887682

Wardlaw J, Bath PMW, Doubal F, Heve A, Sprigg N, Woodhouse LJ, Blair G, Appleton J, Cvoro V, England T, Hassan A, Werring DJ, Montgomery A.  Protocol:  The Lacunar Intervention Trial 2 (LACI-2).  A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease.  European Stroke Journal, online 20th April 2020
 
Werring DJ, Lynch DS.  Monogenic small vessel diseases - rare but still important.  Nature Reviews Neurology, 30th April 2020


2018

Al-Shahi Salman R, Dennis MS, Murray GD, Innes K, ….Werring DJ … Roffe J. The Restart or Stop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial. Trials 2018; 19-1.

Alg VS, Ke X, Grieve J, Bonner S, Walsh DC, Bulters D, Kitchen N, Houlden H, Werring DJ. Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis. British Journal of Neurosurgery, online 15 Jan 2018.

Banerjee G, Alvares D, Bowen J, Adams ME, Werring DJ. Minimally symptomatic cerebral amyloid angiopathy-related inflammation: three descriptive case reports. Journal of Neurology, Neurosurgery, and Psychiatry, online 13 March 2018.

Banerjee G, Wilson D, Ambler G, Osei-Bonsu Appiah K, Shakeshaft C, Lunawat S, Cohen H, Yousry T, Lip GYH, Muir KW, Brown MM, Al-Shahi Salman R, Jäger HR, Werring DJ, CROMIS-2 Collaborators. Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy. Stroke, online 1 January 2018.

Banerjee G, Summers M, Chan E, Wilson D, Charidimou a, Cipolotti L, Werring DJ. Domain-specific characterisation of early cognitive impairment following spontaneous intracerebral haemorrhage. Journal of the Neurological Sciences 2018; 391:25-30.
Goren N, Avery J, Dowrick T, Mackle E, Witkowska-Wrobel A, Werring D, Holder D. Multi-frequency electrical impedance tomography and neuroimaging data in stroke patients. Scientific Data 2018; 5:180112 UCL Discovery

Dineen RA, Pszczolkowski S, Flaherty K … Werring DJ …. Sprigg N. Does tranexamic acid lead to changes in MRI measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? Protocol for a MRI substudy nested within the double-blind randomised controlled TICH-2 trial. BMJ Open 2018; 8-2:e019930.

Hilkens NA, Van Asch CJJ, Werring DJ, Wilson D…Jäger HR … DIAGRAM study group. Predicting the presence of macrovascular causes in non-traumatic intracerebral haemorrhage: the DIAGRAM prediction score. Journal of Neurology, Neurosurgery and Psychiatry, 2018; 18.

Hunter E, Cliff M, Armstrong M, Manji H, Jager HR, Chiodini P, Brown M. Active neurocysticercosis at the Hospital for Tropical Diseases, London: a clinical case series. Transactions of the Royal Society of Tropical Medicine and Hygiene 2018; 112(7):326-334.

Kotecha D, Breithardt G, Camm AJ …. Werring D ….Kirchhof P. Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference. Europace, online 2 Jan 2018.

Lip GYH, Banerjee A, Boriani G, Chiang CE, Fargo R, Freedman B, Lane DA, Ruff CT, Turakhia M, Werring D et al. Antithrombotic therapy for atrial fibrillation: CHEST Guideline and Expert Panel Report. Chest, 2018 in press UCL Discovery

MacGregor Sharp M, Bulters D, Brandner S, Holton J, Verma A, Werring DJ, Carare RO. The fine anatomy of the perivascular compartment in the human brain: relevance to dilated perivascular spaces in cerebral amyloid angiopathy. Neuropathology and Applied Neurobiology, online 27 Feb 2018.

Phyu P, Merwick A, Davagnanam I, Bolsover F, Jichi F, Wheeler-Kingshott C, Golay X, Hughes D, Cipolotti L, Murphy E, Lachmann RH, Werring DJ. Increased resting cerebral blood flow in adult Fabry disease: MRI arterial spin labelling study. Neurology 2018; 90(16):e1379-1385.

Seiffge DJ, Kägi G, Michel P ….Werring D …NOACISP study group. Rivaroxaban plasma levels in acute ischemic stroke and intracerebral haemorrhage. Annals of Neurology, online 2 Feb 2018.

Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O’Brien J, Pantoni L, Pasquier F et al. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. Alzheimer’s and Dementia 2018; 14-3:280-292.


Tsivgoulis G, Wilson D, Katsanos AH, Sargento-Freitas J, Marques-Matos C, Azevedo E, Adachi T, von der Brelie C, Aizawa Y, Abe H et al. Neuroimaging and clinical outcomes of oral anticoagulant associated ICH. Annals of Neurology, online 26th September 2018.

Werring DJ. Winston Churchill's cerebrovascular disease: small vessels with big implications. Journal of the Royal Society of Medicine 2018; 111(9): 314-315.

Werring DJ. CT scanning to diagnose CAA: Back to the future? The Lancet Neurology, online 10 January 2018.20

Wilson D, Ambler G, Shakeshaft C, Brown MM, Charidimou A, Al-Shahi Salman R, Lip GYH, Cohen H, Banerjee G, Houlden H et al. Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attach (CROMIS-2): a multicentre observational cohort study. Lancet Neurology 2018; 17(6): 539-547 UCL Discovery

Ziff OJ, Banerjee G, Ambler G, Werring DJ. Statins and the risk of intracerebral haemorrhage inpatients with stroke: systematic review and meta-analysis. Journal of Neurology, Neurosurgery and Psychiatry, 2018 in press.

Ziff OJ, Werring DJ. Statins after intracranial haemorrhage: seizing a new opportunity? British Journal of Clinical Pharmacology, 2018 in press, UCL Discovery

2017

Banerjee G, Wilson D, Ambler G, Osei-Bonsu Appiah K, Shakeshaft C, Lunawat S, Cohen H, Yousry T, Lip GYH, Muir KW, Brown MM, Al-Shahi Salman R, Jager HR, Werring DJ, CROMIS-2 Collaborators.  Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy.  Stroke, online 15 December 2017. DOI: 10.1161/STROKEAHA.117.019409

Banerjee G, Summers M, Chan E, Wilson D, Charidimou A, Cipolotti L, Werring DJ.  Domain-specific characterisation of cognitive impairment following intracerebral haemorrhage.  International Journal of Stroke, online 1 November 2017.

Banerjee G, Carare R, Cordonnier C, Greenberg SM, Schneider JA, Smith EE, Buchem MV, Grond JV, Berbeek MM, Werring DJ.  The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice.  Journal of Neurology, Neurosurgery and Psychiatry 2017; 88(11): 982-994.  DOI: 10.1136/jnnp-2016-3146974

Banerjee G, Kim HJ, Fox Z, Jaeger HR, Wilson D, Charidimou A, Na HK, Na DL, Seo SW, Werring DJ. MRI-visible perivascular space location is associated with Alzheimer’s disease independently of amyloid burden. Brain 2017; 140:1107-1116 doi: 10.1093/brain/awx003.

Charidimou A, Imaizumi T, Moulin S, Biffi A, Samarasekera N, Yakushiji Y, Peeters A, Vandermeeren Y, Laloux P, Baron J-C et al. Brain Hemorrhage recurrence, small vessel disease type, and cerebral microbleeds: A meta-analysis. Neurology, 2017 Aug 22;89(8):820-829. doi: 10.1212/WNL.0000000000004259. Epub 2017 Jul 26.

Charimidou A, Turc G, Oppenheim C, Yan S, Scheitz JF, Erdur H, Klinger-Gratz PP, El-Koussy M, Takahashi W, Moriya Y et al. Microbleeds, cerebral haemorrhage, and functional outcome after stroke thrombolysis: individual patient data meta-analysis. Stroke, published online 18th July 2017 doi: 10.1161/STROKEAHA.116.012992. [Epub ahead of print]

Croall ID, Lohner V, Moynihan B, Khan U, Hassan A, O-Brien JT, Morris RG, Tozer DJ, Cambridge VC, Harkness K. Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies. Clinical Science 2017; 131(2):1361-1373 doi: 10.1042/CS20170146. Print 2017 Jun 1.

Hostettler Moreno I, Alg V, Shabi N, Jichi F, Bonner S, Walsh D, Bulters D, Kitchen N, Brown M, Houlden H et al. Characteristics of unruptured compared to ruptured intracranial aneurysms: A multicentre case-control study. Neurosurgery 2017 Jul 25. doi: 10.1093/neuros/nyx365. [Epub ahead of print]

Jakel L, Van Nostrand WE, Nicoll JAR, Werring DJ, Verbeek MM.  Animal models of cerebral amyloid angiopathy.  Clin Sci (Lond) 2017; 131(19):2469-2488.  DOI: 10.1042/CS20170033

Jang YK, Kim HJ, Lee JS, Kim YJ, Kim KW, Kim Y, Jang H, Lee J, Lee JM, Kim S-J et al.  Distinctive clinical effects of haemorrhagic markers in cerebral amyloid angiopathy.  Scientific Reports 22 November 2017; 7(1):15984.  DOI: 10.1038/s41598-017-16298-1

Koohi N, Vickers DA, Lakshmanan R, Chandrashekar H, Werring DJ, Warren JD, Bamiou D-E. Hearing characteristics of stroke patients: prevalence and characteristics of hearing impairment and auditory processing disorders in stroke patients. Journal of the American Academy of Audiology 2017; 28(6):491-505 10.doi: 10.3766/jaaa.15139.

Koohi N, Vickers D, Warren J, Werring D, Bamiou DE. Long-term use benefits of personal frequency-modulated systems for speech in noise perception in patients with stroke with auditory processing deficits: A non-randomised controlled trial study. BMJ Open 2017; 7(4) http://dx.doi.org/10.1136/bmjopen-2016-013003

Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O'Brien J, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I, VICCCS group et al.   Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study.  Alzheimers Dement, online 19 October 2017.  DOI:  10.1016/j.jalz.2017.09.007

Skrobot OA, Love s, Kehoe PG, O’Brien J, Black S, Chen C, DeCarli C, Erkinjuntti T, ford GA, Kalaria RN et al. The vascular impairment of cognition classification consensus study. Alzheimer’s and Dementia 2017; 13(6):624-633 doi: 10.1016/j.jalz.2016.10.007. Epub 2016 Dec

Turner D, Scully M, Stone S, Werring DJ. Recurrent brain ischaemia and deep vein thrombosis: the clot thickens. Practical Neurology 2017 Oct;17(5):380-382. doi: 10.1136/practneurol-2016-001581. Epub 2017 Jun 3.

Wilson D, Seiffge DJ, Traenka C, Basir G, Purrucker JC, Rizos T, Sobowale OA, Sallinen H, Yeh S-J, Wu TY et al. Outcome of intracerebral haemorrhage associated with different oral anticoagulants. Neurology 2017; 88(18):1693-1700 doi: 10.1212/WNL.0000000000003886. Epub 2017 Apr 5.

Wilson D, Chatterjee F, Farmer SF, Rudge P, McCarron MO, Cowley P, Werring DJ. Infratentorial superficial siderosis: classification, diagnostic criteria, and rational investigation pathway. Annals of Neurology 2017; 81(3):333-343 doi: 10.1002/ana.24850. Epub 2017 Jan 28.

Wilson D, Hostettler IC, Ambler G, Banerjee G, Jager HR, Werring DJ. Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy. Journal of Neurology 2017; 264(4):664-673 doi: 10.1007/s00415-017-8398-y. Epub 2017 Feb 2.

Yakushiji Y, Charidimou A, Noguchi T, Nishihara M, Eriguchi M, Nanri Y, Kawaguchi A, Hirotsu T, Werring DJ, Hara H.  Total small vessel disease score in neurologically healthy Japanese adults in the Kashima scan study.  Internal Medicine, online 16 October 2017.  DOI:  10.2169/internalmedicine.8393-16

2016

Chan E, Altendorff S, Healy C, Werring DJ, Cipolotti L. The test accuracy of the Montreal Cognitive Assessment (MoCA) by stroke lateralisation. J Neurol Sci. 2017 Feb 15;373:100-104.doi: 10.1016/j.jns.2016.12.028. Epub 2016 Dec 19.

Charidimou A, Schmitt A, Wilson D, Yakushiji Y, Gregoire SM, Fox Z, Jäger HR, Werring DJ. The Cerebral Haemorrhage Anatomical RaTing inStrument (CHARTS): Development and assessment of reliability. J Neurol Sci. 2017 Jan 15;372:178-183.doi: 10.1016/j.jns.2016.11.021. Epub 2016 Nov 12. 

Jiad E, Gill SK, Krutikov M, Turner D, Parkinson MH, Curtis C, Werring DJ. When the heart rules the head: ischaemic stroke and intracerebral haemorrhage complicating infective endocarditis. Pract Neurol. 2017 Jan;17(1):28-34. doi: 10.1136/practneurol-2016-001469. Epub 2017 Jan 3.

Kongbunkiat K, Wilson D, Kasemsap N, Tiamkao S, Jichi F, Palumbo V, Hill MD, Buchan AM, Jung S, Mattle HP, Henninger N, Werring DJ. Leukoaraiosis, intracerebral hemorrhage, and functional outcome after acute stroke thrombolysis. Neurology. 2017 Feb 14;88(7):638-645. doi: 10.1212/WNL.0000000000003605. Epub 2017 Jan 27.

Koohi N, Vickers D, Chandrashekar H, Tsang B, Werring D, Bamiou DE2. Auditory rehabilitation after stroke: treatment of auditory processing disorders in stroke patients with personal frequency-modulated (FM) systems. Disabil Rehabil. 2017 Mar;39(6):586-593. doi: 10.3109/09638288.2016.1152608. Epub 2016 Mar 23.

Muir KW, Ford GA, Messow CM, Ford I, Murray A, Clifton A, Brown MM, Madigan J, Lenthall R, Robertson F, Dixit A, Cloud GC, Wardlaw J, Freeman J, White P; PISTE Investigators. Endovascular therapy for acute ischaemic stroke: the Pragmatic Ischaemic Stroke Thrombectomy Evaluation (PISTE) randomised, controlled trial. J Neurol Neurosurg Psychiatry. 2017 Jan;88(1):38-44. doi: 10.1136/jnnp-2016-314117. Epub 2016 Oct 18.

Wilson D, Werring DJ. Antithrombotic therapy in patients with cerebral microbleeds. Curr Opin Neurol. 2017 Feb;30(1):38-47. doi: 10.1097/WCO.0000000000000411.

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