UCL Queen Square Institute of Neurology


Brain Tumour Group

A multi-disciplinary group researching brain tumour pathophysiology, diagnosis and therapeutics with an emphasis on gliomas and pituitary tumours.

Brain Tumour group

Research Team

Neuroradiology: Dr Harpreet Hyare PhD
Neurosurgery: Mr Hani Marcus PhD
Neurology: Dr Jeremy Rees MD

Research Goals

  • To develop novel, evidence-based imaging methods for improved non-invasive diagnosis, surgical planning and prognostication in patients with brain tumours.
  • To harness recent developments in technologies such as augmented reality, robotics and artificial intelligence in patients undergoing brain tumour surgery.
  • To develop multi-modal models in patients with brain tumours for individual-level treatment prescription.

Funded Research Projects

  • High Dimensional Modelling in Gliomas.
  • Predicting Response to Radiotherapy in Malignant Glioma using FAPI PET-MRI and Advanced Histological Methods. 
  • Non-invasive quantification of Microstructure and Metabolic Microenvironment in Teenage and young Adult Gliomas Undergoing Treatment grant to develop DW-MRS in gliomas.
  • AID-PitSurg: AI-enabled Decision support in Pituitary Surgery to reduce complications.
  • Context Aware Augmented Reality For Endonasal Endoscopic Surgery.
  • Interchangeable handheld robotic instruments for keyhole neurosurgery.
  • Electrophysiological monitoring for the prevention of brain retraction injury in neurosurgery.


Recent publications
  • Brain tumour genetic network signatures of survival.
    Ruffle JK, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H, Nachev P.Brain. 2023 Sep 4:awad199. doi: 10.1093/brain/awad199. Online ahead of print.PMID: 37665980
  • Evaluating drug distribution in children and young adults with diffuse midline glioma of the pons (DIPG) treated with convection-enhanced drug delivery.
    Szychot E, Bhagawati D, Sokolska MJ, Walker D, Gill S, Hyare H.Front Neuroimaging. 2023 Feb 28;2:1062493. doi: 10.3389/fnimg.2023.1062493. eCollection 2023.PMID: 37554653 
  • Steps on the Path to Clinical Translation: A workshop by the British and Irish Chapter of the ISMRM.
    Hubbard Cristinacce PL, Markus JE, Punwani S, Mills R, Lopez MY, Grech-Sollars M, Fasano F, Waterton JC, Thrippleton MJ, Hall MG, O'Connor JPB, Francis ST, Statton B, Murphy K, So PW, Hyare H.Magn Reson Med. 2023 Sep;90(3):1130-1136. doi: 10.1002/mrm.29704. Epub 2023 May 24.PMID: 37222226 Review.
  • Brain tumour segmentation with incomplete imaging data.
    Ruffle JK, Mohinta S, Gray R, Hyare H, Nachev P.Brain Commun. 2023 Apr 28;5(2):fcad118. doi: 10.1093/braincomms/fcad118. eCollection 2023.PMID: 37124946 
  • Graph lesion-deficit mapping of fluid intelligence.
    Cipolotti L, Ruffle JK, Mole J, Xu T, Hyare H, Shallice T, Chan E, Nachev P.Brain. 2023 Jan 5;146(1):167-181. doi: 10.1093/brain/awac304.PMID: 36574957