Brain Tumour Group

A multi-disciplinary group researching brain tumour pathophysiology, diagnosis and therapeutics with an emphasis on gliomas and pituitary tumours.

To develop novel, evidence-based imaging methods for improved non-invasive diagnosis, surgical planning and prognostication in patients with brain tumours.
To harness recent developments in technologies such as augmented reality, robotics and artificial intelligence in patients undergoing brain tumour surgery.
To develop multi-modal models in patients with brain tumours for individual-level treatment prescription.

High Dimensional Modelling in Gliomas.
Predicting Response to Radiotherapy in Malignant Glioma using FAPI PET-MRI and Advanced Histological Methods.
Non-invasive quantification of Microstructure and Metabolic Microenvironment in Teenage and young Adult Gliomas Undergoing Treatment grant to develop DW-MRS in gliomas.
AID-PitSurg: AI-enabled Decision support in Pituitary Surgery to reduce complications.
Context Aware Augmented Reality For Endonasal Endoscopic Surgery.
Interchangeable handheld robotic instruments for keyhole neurosurgery.
Electrophysiological monitoring for the prevention of brain retraction injury in neurosurgery.

Brain tumour genetic network signatures of survival.
Ruffle JK, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H, Nachev P.Brain. 2023 Sep 4:awad199. doi: 10.1093/brain/awad199. Online ahead of print.PMID: 37665980
Evaluating drug distribution in children and young adults with diffuse midline glioma of the pons (DIPG) treated with convection-enhanced drug delivery.
Szychot E, Bhagawati D, Sokolska MJ, Walker D, Gill S, Hyare H.Front Neuroimaging. 2023 Feb 28;2:1062493. doi: 10.3389/fnimg.2023.1062493. eCollection 2023.PMID: 37554653
Steps on the Path to Clinical Translation: A workshop by the British and Irish Chapter of the ISMRM.
Hubbard Cristinacce PL, Markus JE, Punwani S, Mills R, Lopez MY, Grech-Sollars M, Fasano F, Waterton JC, Thrippleton MJ, Hall MG, O'Connor JPB, Francis ST, Statton B, Murphy K, So PW, Hyare H.Magn Reson Med. 2023 Sep;90(3):1130-1136. doi: 10.1002/mrm.29704. Epub 2023 May 24.PMID: 37222226 Review.
Brain tumour segmentation with incomplete imaging data.
Ruffle JK, Mohinta S, Gray R, Hyare H, Nachev P.Brain Commun. 2023 Apr 28;5(2):fcad118. doi: 10.1093/braincomms/fcad118. eCollection 2023.PMID: 37124946
Graph lesion-deficit mapping of fluid intelligence.
Cipolotti L, Ruffle JK, Mole J, Xu T, Hyare H, Shallice T, Chan E, Nachev P.Brain. 2023 Jan 5;146(1):167-181. doi: 10.1093/brain/awac304.PMID: 36574957