The role of thrombogenic factors and factor XIII in recurrent pregnancy failure
This work is an investigation into haemostatic and thrombotic factors influencing early pregnancy and their associations with pregnancy outcome. It will look at both women with a history of recurrent miscarriage and women undergoing assisted reproductive technology treatment (in vitro fertilisation – IVF) as examples of cases where normal physiology may be disrupted and where medical treatment is already routine and might be improved upon. Pregnancy failure is a significant source of both physical and psychological stress for affected women. In vitro fertilization (IVF) is a national women’s health issue of growing importance with the number of women undergoing IVF steadily increasing. Evidence suggests that some cases of IVF failure may have a thrombotic basis. Thrombin generation (TG), which provides a global measure of thrombogenic potential, has been shown to have predictive value for the development of recurrent venous thromboembolism. Its role in IVF is undetermined. Severe congenital FXIII deficiency is a known risk factor for miscarriage however it is not known whether a borderline FXIII level may also be contributory. This project is investigating what role TG testing and FXIII levels may have in the context of patients undergoing IVF as well as those with a history of recurrent miscarriage.
Haemostasis Research Unit