EGA Institute for Women's Health


Subhabrata Mitra

Subhabrata Mitra

Project title

Predictive role of Cytochrome C Oxidase measured by broadband near infrared spectroscopy as a real time biomarker of newborn brain injury

Project description 

Newnorn brain injury, particularly hypoxic ischemic encephalopathy (HIE) leads to significant morbidity and mortality. In spite of significant progress in the last decade, a large proportion of infants still die after the cooling treatment following HIE. There is an unmet demand to identify infants with severe injuries early at the cot side and to better understand the background pathophysiological changes and response to cooling treatment.
Disturbances in cerebral oxidative metabolism following HIE are well documented. Cytochrome-c-oxidase (CCO) is the terminal electron acceptor in the mitochondrial electron transport chain and plays a central role in mitochondrial oxidative metabolism and ATP synthesis. Using a novel broadband near infrared spectroscopy system I am investigating cerebral metabolism, oxygenation and haemodynamics in infants following brain injury at the cot side.
Preliminary results from this study in infants with HIE, neonatal seizures and neonatal stroke have already been published in peer reviewed journals.

Start date

Primary supervisor 

Prof Nikki Robertson

Based at

Rockefeller Building


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