EGA Institute for Women's Health


Presentation at Annual Conference on Brain Disorders, Neurology and Therapeutics, Paris, October 201

21 November 2018

Claudia Siso, member of the Department of Maternal & Fetal Medicine recently presented at the Annual Conference on Brain Disorders, Neurology and Therapeutics in Paris on 15-16 October 2018

Claudia Sisa, PhD Student, Institute for Women's Health
Claudia Sisa, PhD student, presented on ‘Complement system in Neonatal Hypoxia-Ischemia injury: the role of the alternative pathway’

The presentation highlighted the aim to understand the role of the alternative pathway of the complement system in neonatal hypoxia-ischemia brain damage.  Using knock out mice they found that the activation of the alternative pathway increases the damage in the HI brain.

They are now planning to test a pharmaceutical compound to inhibit this pathway chemically and have a neuroprotective effect. This is groundbreaking research as no one has looked at this pathway in neonatal HI before and seen the current lack of effective treatments for this disease we might give hope to families with babies born with such disease.