Virtual virology regularly features inspiring talks from members of prominent virology labs. See below for some previous titles:
Date: Thursday 5th March
Host: Prof Paul Lehner (Cambridge) and his lab
Title: Viral Silencing and Immune Evasion
Marta Seczynska - What do we know about HUSH-mediated transcriptional repression?
Liane Dupont - Are unintegrated human lentiviruses silenced by HUSH?
Dan Greaves - Locus-specific Proteomics Identifies Latent EBV-specific Silencers
Date: Thursday 30th Jan
Host: Jason Mercer (UCL) and his lab.
Title: Introduction: “The Ins and Outs of Poxvirus Infection”
Laura Pokorny: Studying vaccinia virus binding and fusion using a minimal model system
Susanna Bidgood: The Poxvirus Lateral Body Proteome: Characterising enigmatic structures
Moona Huttunen: Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress
Artur Yakimovich: Viruses versus Machines: Deep Learning to Analyze Host-Pathogen Interactions
Date: Thursday 28th November
Host: Prof Ian Humphries, Dr Rich Stanton, Dr Eddie Wang and others
Title: CMV Research in Cardiff
Date: Thursday 31st October
Host: Dr Clare Jolly
Title: Introduction: HIV and CD4+ T cells
Ann-Kathrin Reuschl: HIV turns T cells into remainers
Dejan Mesner: The enigma of lentiviral Nef
Tafhima Haider: The tale of the Env cytoplasmic tail
Thursday 16 May 2019
Host: Prof Ian Goodfellow, Cambridge
Title: Noroviruses - the perfect pathogen
Luke Meredith - Generation of novel tools for the study of immune responses to noroviruses and viral entry pathways
Jia (Luca) Lu - Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation
Myra Hosmillo - Utilisation of intestinal organoids as tool to study human noroviruses
Thursday 28 March 2019
Host: Dr John Briggs, MRC Laboratory of Molecular Biology, Cambridge.
Title: Assembly, maturation and evolution of retroviruses - insights from cryo-EM.
Thursday 28 February 2019
Host: Prof Stuart Neil, KCL
Title: 'TRIM25 and ZAP – antiviral suppression of CpG dinucleotides in RNA viruses'
Chad Swanson: 'Introduction: suppression of CpGs in RNA virus genomes'
'TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex':
- Rui Pedro Galao: 'TRIM25 and ZAP mediate interferon-induced restriction of Ebola virus'
- Harry Wilson: 'Mechanistic insights into the targeting of the EBOV vRNP by TRIM25'
Irati Antzin Anduetza: 'Context and position dependent Inhibition of HIV-1 replication by CpG dinucleotides in the viral genome'
Mattia Ficarelli: 'Identification of an essential cofactor for ZAP-mediated suppression of HIV-1 containing clustered CpG dinucleotides'
Thursday November 22nd 2018
Host: Dr Serge Mostowy, LSHTM
Sina Krokowski: Septins recognise and entrap dividing bacterial cells for delivery to lysosomes
Julia Pfanzelter (The Francis Crick Institute): Septins suppress the release of vaccinia virus from infected cells
Vincenzo Torraca: Use of zebrafish to study septin-mediated cellular immunity
Vanessa Sancho-Shimizu (Imperial College London): Herpes encephalitis: a human genetics perspective
Thursday September 13th 2018
Subject: 'Real-time molecular epidemiology for outbreak response'
Ian Goodfellow – University of Cambridge: Setting up field laboratories in outbreak conditions – a personal perspective.
Kirstyn Brunker - University of Glasgow: Field-deployable genomic surveillance to guide rabies elimination.
Andrew Rambaut – University of Edinburgh: Genomic epidemiology of outbreaks and epidemics – insights from the Ebola virus epidemic.
Nick Loman – University of Birmingham: Future perspectives, ARTIC, nanopore sequencing.
Thursday May 17th 2018
Host: Dr Leo James
Title: 'How does HIV carry out reverse transcription inside the closed capsid?'
David Jacques, UNSW Sydney: When too many structures is barely enough: What (we think) we’ve learned by comparing HIV and SIV capsids.
Till Böcking, UNSW Sydney: How to tweak HIV capsid stability: Control of uncoating kinetics revealed by single-molecule imaging
Donna Mallery, MRC LMB, Cambridge: IP6 is an HIV pocket factor that regulates capsid assembly and disassembly
Thursday March 15th 2018
Host: Prof Mala Maini, University College London
Dr Laura Pallett: 'Targeting liver-resident T cells'
Alice Burton: 'Can we harness the B cell response to HBsAg?'
Dr Kerstin Stegmann: 'Do NK cells have antiviral potential in HBV?'
Dr Mariana Diniz: 'Immunotherapeutic strategies in the adeno-HBV model'
Thursday January 18th 2018
Host: Early Career Investigators Session:
Will McEwen - University of Cambridge
Dalan Bailey - The Pirbright Institute
Katrina Lythgoe - University of Oxford
Will McEwen: Redirecting the antiviral Fc receptor TRIM21 against toxic host proteins
Dalan Bailey: Structure guided identification of a pathogen with pandemic potential
Katrina Lythgoe: Evolution of chronic viruses within and between hosts
Thursday November 16th 2017
Host: Early Career Investigators Session:
Chris Illingworth - Department of Genetics, University of Cambridge
Naomi McGovern - Department of Pathology, University of Cambridge
Petra Mlcochova - Division of Infection and Immunity, UCL
Chris Illingworth: Evolution on sub-phylogenetic timescales: Measuring influenza reassortment within a human host
Naomi McGovern: Human mononuclear phagocytes - from foetus to adult
Petra Mlcochova: A novel aspect of Macrophage biology: learning from the great opportunist HIV-1
Thursday July 20th 2017
Host: Prof Mike Malim, King's College London
Darja Pollpeter: “Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted anti-viral functions of APOBEC3G”
Luis Apolonia: “Host proteins involved in early steps of HIV-1 infection”
Matt Dicks: “Unraveling the mechanism of MX2 mediated inhibition of HIV-1”
Thursday May 18th 2017
Host: Early Career Investigators
Pierre Maillard, University College London: "Unmasking the antiviral activity of RNA interference in mammalian cells".
Carlos Maluquer de Motes, University of Surrey: "Poxviruses and the ubiquitin system: Cullin' innate immunity".
Ben Longdon, University of Exeter: "Virus host shifts".
Thursday March 23rd 2017
Host: Prof Judy Breuer, University College London
Prof Judy Breuer. “Genes trees and variants; making biological sense of viral genomics”
Juliana Cudini. "Within host viral diversity; comparing CMV with RNA viruses"
Chris Ruis. "Hiding in plain site: What drives norovirus pandemics?"
Dan Depledge. "The Forever War - New insights into host and viral transcriptomics during alphaherpesviral latency"
Thursday 23rd February 2017
Host: Prof Martin Allday, Imperial College London
Dr Kostas Paschos: “Combining ChIP-‐seq data and gene expression profiles reveals general principles of EBNA3-‐mediated gene regulation during EBV latency.”
Dr Quentin Bazot: “Inhibition of cyclin-‐dependent kinase inhibitors (CDKI) by EBNA3A and EBNA3C in EBV-‐infected/transformed B cells: mechanisms and biological consequences.”
Christine Styles: “EBNA3A and EBNA3C have co-‐evolved to epigenetically suppress the B cell-‐to-‐plasma cell differentiation pathway, favouring persistence in memory B cells.”
Thursday 19th January 2017
Host: Prof Jan Rehwinkel, University of Oxford
Jan Rehwinkel: "Introduction – Nucleic Acid Sensing by Innate Receptors"
Jonathan Maelfai: "Sensing of viral and endogenous Z-RNA by ZBP1/DAI induces necroptosi"
Antonio Gregorio Dias Junio: "Zika virus and type I interferons"
Thursday 15th December 2016
Host: Dr Marcus Dorner, Imperial College, London.
Marcus Dorner: “Studying human-tropic infectious diseases using human xenograft models and tissue engineering”
Ana Maria Ortega-Prieto: “Evaluating single-cell host/pathogen interactions in 3D microfluidic human liver cultures”
Jessie Skelton: “Innate immune responses to HIV infection in humanised mice”
Thursday 17th November 2016
Early career investigator session:
Joe Grove, UCL
Goedele Maertens, Imperial College.
Trevor Sweeney, University of Cambridge
Joe Grove: "Why is hepatitis C virus entry so complex?"
Goedele Maertens: "Host determinants of delta-retroviral integration"
Trevor Sweeney: "Understanding the translation landscape at the host pathogen interface"
Thursday 20th October 2016
Hosts: Peter Stockley, University of Leeds and Reidun Twarock, University of York
Introduction: "Novel RNA regulated assembly mechanisms in single-stranded RNA viruses"
Peter Stockley: "Probing packaging signal mediated assembly mechanisms in viruses infecting bacteria, plants and man"
Reidun Twarock: " The mechanism and evolutionary consequences of packaging signal mediated assembly and further extensions to Hepatitis B virus and HIV"
Thursday 22nd Sept 2016
Host: Prof Wendy Barclay, Imperial College London
Jason Long: "Defining Host range barriers that limit avian influenza polymerase in human cells"
Wendy Barclay and Hui Li: "Understanding the severity of zoonotic avian influenza viruses"
Daniel Goldhill: "Measuring the error rate of influenza polymerase to track pandemic evolution"
Anika Singanayagam: "The balance between pH stability of influenza HA protein, transmission and virulence"
Wendy Barclay and Rebecca Frise: "Counting influenza transmission"
Thursday 21st July 2016
Host: Michael Way and Antonio Postigo, Francis Crick Institute
Dr Antonio Postigo: “Vaccinia induces a cytoplasmic DNA damage response to facilitate replication”
Dr Xenia Snetkov: “The role of endocytic signalling networks in the release of Vaccinia virus”
Thursday 16th June 2016
Host: Prof Greg Towers, Infection and Immunity, UCL
Dr Jane Rasaiyaah: HIV-1 Capsid regulates DNA synthesis by forming a regulated electrostatic nucleotide channel
Dr Katsia Bichel: Use of solution state NMR to understand how HIV-1 Capsid-cofactor interactions regulate infectivity
Dr Maria T. Rodriguez Plata: HIV-1 infection and innate sensing in primary CD4+ T cells
Dr Becky Sumner: HIV-1 Vpr antagonises innate sensing of viral DNA
Thursday 19th May 2016
Host: Dr Ravi Gupta, Infection and Immunity, UCL
Dr Ravi Gupta: 'HIV-1 Drug Resistance following global scale up of antiretroviral therapy'
Dr Katherine Sutherland: 'Mechanisms of resistance to HIV protease inhibitors'
Dr Petra Mlcochova: 'SAMHD1 regulation by cell cycle explains HIV-1 Vpx independent replication in macrophages'
Thursday 25th February 2016
Host: Peter Cherepanov, Francis Crick Institute
Peter Cherepanov: “Role of chromatin structure in retroviral integration"- Introduction
Dan Maskell: The mechanism of nucleosome capture by the retroviral preintegration complex
Paul Lesbats: Role of capsid in integration of spumaviruses
Thursday 21st January 2016
Host: Dr Ian Taylor, Francis Crick Institute
Dr Ian Taylor: Introduction: "Structural biology of retrovirus assembly, restriction and cellular defense evasion”
Neil Ball: Structural insights into PFV Gag assembly
Sarah Caswell: Structural and mechanistic investigation of SAMHD1 retroviral restriction
David Schwefel: Counteraction of SAMHD1 restriction by the accessory protein Vpx
Thursday 19th November 2015
Host: Dr Jason Mercer, LMCB UCL
Dr Jason Mercer: The Double Life of the Vaccinia Dual Specificity Phosphatase H1
Corina Beerli: Vaccinia virus induced cell motility
Rob Gray: VirusMapper: modelling vaccinia structure with super-resolution microscopy
Thursday 22nd October 2015
Host: Prof Gavin Screaton, Imperial College
Prof Gavin Screaton: Study of Dengue Virus infection: toward antiviral and vaccine design
Thursday 28th May 2015
Host: Professor Paul Lehner, University of Cambridge.
Nick Matheson: Mapping the plasma membrane proteome in HIV infection
Dick van den Boomen: CMV encoded US2 and US11 as viral degradation hubs for immunoreceptors
Iva Tchasovnikarova: Genetic screens identify a novel epigenetic repressor complex
Thursday 26 March 2015
Host: Prof Charles Bangham, Imperial College
Prof Charles Bangham: HTLV-1 – regulation of clonality and latency.
Michi Miura: Applying CRISPR to test the function of CTCF in HTLV-1
Hiroko Yaguchi and Anat Melamed: HTLV-1 modifies higher-order structure of host chromatin
Thursday 26 February 2015
Host: Dr Stuart Neil, King’s College London School of Life Science and Medicine
Dr Toshana Foster: Innate antiviral restriction of HIV-1 entry
Dr Gregory Berger: Modulation of proinflammatory signaling and DNA repair pathways by lentiviral Vpr proteins
Ms Julia Weinelt: Differential antiviral activities of human tetherin isoforms
Thursday 22 January 2015
Host: Prof Gavin Wilkinson, Cardiff University
Rich Stanton: HCMV - building a wildtype virus
Peter Tomasec: MEGAproteomics! All the cool kids are doing it
Ian Humphreys: Cytokine Regulation of Immunity to Cytomegalovirus
Thursday 20 November 2014
Host: Prof Ian Goodfellow, University of Cambridge.
Dr Armando Arias: Favipiravir, a broad-range antiviral nucleoside, can drive virus extinction in vivo through increased mutagenesis.
Dr Ed Emmott: Norovirus modulates cellular protein translation to impair the immune response to viral infection
Dr Lucy Thorne: Harnessing the Cellular miRNA machinery to Probe Norovirus Tropism
Thursday 15 May 2014
Host: Mike Mailm, Dept of Infectious Diseases, King's College London.
Katie Doores: The HIV glycan shield as a target for broadly neutralizing antibodies
Els Henckaerts: Molecular mechanisms of a nonpathogenic virus
Maria Teresa Catanese: The cell biology of HCV infection: entry and persistence
Thursday 20 March 2014,
Host: John Sinclair, Division of Medicine, University of Cambridge
Joint title: Human cytomegalovirus latency: host/cell interactions and identification of novel targets with a view to eliminating latently infected cells
Prof John Sinclair: Setting the scene
Dr Emma Poole: Changes in cellular gene expression during latency
Dr Mark Wills: Immune responses to latent infection
Prof John Sinclair: Therapeutic targeting of latent infection
Thursday 16 January 2014
Host: Geoff Smith, Department of Pathology, University of Cambridge
Prof Geoffrey Smith: How does vaccinia virus form a plaque?
Dr Rebecca Sumner: Innate immune evasion mechanisms of vaccinia virus and their contribution to virulence and immunogenicity
Dr Michela Mazzon: Reprogramming of cell metabolism by vaccinia virus: a mechanism and role for the stabilisation of the transcription factor HIF-1α
Thursday 20 June 2013
Host: Steve Goodbourn, Division of Basic Medical Sciences, St. George's (University of London)
Prof Steve Goodbourn: Interfering with interferon; viruses fight back
Dr Craig Ross: Structure of interferon-inducing PAMPs generated by paramyxovirus infections
Dr Kay Childs: Regulation of RNA helicases by paramyxovirus accessory proteins