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UCL Queen Square Institute of Neurology

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Selected Papers

(2007-)

  • Theparambil SM, Kopach O, Braga A, Nizari S, Hosford PS, Sagi-Kiss V, Hadjihambi Anna, Konstantinou C, Esteras N, Del Arroyo AG, Ackland GL, Teschemacher AG, Dale N, EckleT, Andrikopoulos P, Rusakov DA, Kasparov S, Gourine AV (2024) Adenosine signaling to astrocytes coordinates brain metabolism and function. Nature (in press).
  • Rusakov DA (2024) Avoiding bias in fluorescence sensor readout. Nature Rev Neurosci 25: 1-2 (link). 
  • Magloire V, Savtchenko LP, Jensen TP, Sylantyev S, Kopach O, Cole N, Tyurikova O, Kullmann DM, Walker MC, Marvin JS, Looger LL, Hasseman JP, Kolb I, Pavlov I, Rusakov DA (2023) Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network. Curr Biol 33: 1249-1264.e7 (link).
  • Rusakov DA (2023) A misadventure of the correlation coefficient. Trends Neurosci 46: 94-96 (link).
  • Rusakov DA (2022) Avoiding interpretational pitfalls in fluorescence imaging of the brain. Nature Rev Neurosci 23: 705–706 (link).
  • Michaluk P, Rusakov DA (2022) Monitoring protein cell-membrane dynamics using whole-cell FRAP of pH-sensitive genetic tags. Nature Protocols 17: 3056–3079 (link).
  • Esteras N, Kopach O, Maiolino M, Lariccia V, Amoroso S, Qamar S, Wray S, Rusakov DA, Jaganjac M, Abramov AY (2022) Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia. Alzheimer's & Dementia 18: 318-338 (link).
  • Tyurikova O, Shih P-Y, Dembitskaya Y, Savtchenko LP, McHugh TJ, Rusakov DA#, Semyanov A# (2022) K+ efflux through postsynaptic NMDA receptors suppresses local astrocytic glutamate uptake. Glia 70: 961-974 (link).
  • Michaluk P#, Heller JP, Rusakov DA# (2021) Rapid recycling of glutamate transporters on the astroglial surface. eLife 10: e64714, pp 1-18 (link). 
  • Kopach O#, Esteras  N, Wray S, Abramov AY, Rusakov DA (2021) Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia. Cell Death & Disease 12: 716 (link).
  • Jensen TP#, Kopach O, Savtchenko LP, Reynolds JP, Rusakov DA# (2021) Release probability increases towards distal dendrites boosting high-frequency signal transfer in the rodent hippocampus. eLife 10: e62588, pp 1-20 (link).
  • Henneberger C#, Bard L, Panatier A, Reynolds JP, Kopach O, Medvedev NI, Minge D, Herde MK, Anders S, Kraev I, Heller JP, Rama S, Zheng K, Jensen TP, Sanchez-Romero I, Jackson C, Janovjak H, Ottersen OP, Nagelhus EA, Oliet SHP, Stewart MG#, Nägerl UV#, Rusakov DA# (2020) LTP induction boosts glutamate spillover by driving withdrawal of perisynaptic astroglia. Neuron 108: 919-936 (link). (Nat Rev Neurosci highlight)
  • Theparambil S, Hosford P, Ruminot I, Kopach O, Reynolds JP, Sandoval P, Rusakov DA, Barros LF, Gourine A (2020) Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle. Nature Commun 11: 1-15 (link).
  • Rusakov DA, Savtchenko LP, Latham PE (2020) Noisy synaptic conductance: bug or a feature? Trens Neurosci 43: 363-372 (link).
  • King CM, Bohmbach K, Minge D, Delekate A, Zheng K, Reynolds J, Rakers C, Zeug A, Petzold GC, Rusakov DA#, Henneberger C# (2020) Local resting Ca2+ controls the scale of astroglial Ca2+ signals. Cell Reports 30: 3466-347 (link).
  • Marvin JS, Shimoda Y, Magloire V, Leite M, Jensen TP, Kolb I, Knott EL, Novak O, Podgorski K, Leidenheimer NJH, Rusakov DA, Ahrens MB, Kullmann DM, Looger LL (2019) A genetically encoded fluorescent sensor for in vivo imaging of GABA. Nature Methods 16: 763-770 (link). 
  • Jensen TP, Zheng K, Cole N, Marvin JS, LoogerLL, Rusakov DA (2019) Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ. Nature Commun 10: 1414 pp 1-11 (link)
  • Kellermayer B, Ferreira JS, Dupuis J, Levet F, Grillo-Bosch D, Bard L, Linarès-Loyez J, Bouchet D, Choquet D, Rusakov DA, Bon P, Sibarita JB, Cognet L, Sainlos M, Carvalho AL, Groc L (2018) The nanoscale topography of GluN2-NMDA receptor subtypes tunes plasticity at glutamatergic synapses. Neuron 100: 106-119 (link).
  • Savtchenko LP*, Bard L*, Jensen TP, Reynolds JP, Kraev I, Medvedev N, Stewart MG, Henneberger C, Rusakov DA (2018) Disentangling astroglial physiology with a realistic cell model in silico. Nature Commun 9: 3554 (pp 1-12) (link).
  • Rusakov DA (2018) An optical sensor to monitor dynamics of extracellular glycine. Nature Chem Biol 14: 835-836 (link). 
  • Zheng K, Jensen TP, Rusakov DA (2018) Monitoring intracellular nanomolar calcium using fluorescence lifetime imaging. Nature Protocols 13: volume 581-597 (link). 
  • Papouin T, Henneberger C, Rusakov DA, Oliet SHR (2017) Astroglial versus Neuronal D-Serine: Fact Checking. Trends Neurosci 17: 30107-8 (link).
  • Savtchenko LP, Poo MM, Rusakov DA (2017) Electrodiffusion phenomena in neuroscience: a neglected companion. Nature Rev Neurosci 18: 598-612 (link).
  • Mishra A, Reynolds JP, Chen Y, Gourine AV, Rusakov DA, Attwell D (2016)  Astrocytes mediate neurovascular signalling to capillary pericytes but not to arterioles. Nature Neurosci 19: 1619–1627 (link).
  • Boddum K*, Jensen TP*, Magloire V, Kristiansen U, Rusakov DA#, Pavlov I#, Walker MC# (2016) Astrocytic GABA transporter activity modulates excitatory neurotransmission. Nature Commun 7: 13572, pp 1-10. (link).
  • Zheng K*, Bard L*, Reynolds J, King K, Jensen TP, Gourine AV, Rusakov DA (2015) Time-resolved imaging reveals heterogeneous landscapes of nanomolar Ca2+ in neurons and astroglia. Neuron 88: 277-288 (link).
  • Rusakov DA (2015) Disentangling calcium-driven astrocyte physiology. Nature Rev Neurosci 16: 226-233 (link).
  • Witton J*, Padmashri R*, Zinyuk LE*, Popov VI, Kraev I, Line SJ, Jensen TP,Tedoldi A, Cummings DM, Tybulewicz VLJ, Fisher EMC, Bannerman DM, Randall AD, Brown JT, Edwards FA, Rusakov DA, Stewart MG, Jones MW (2015) Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nature Neurosci 18: 1291–1298 (link). 
  • Scott R*, Henneberger C*, Padmashri R*, Anders S, Jensen T, Rusakov DA (2014) Neuronal adaptation involves rapid expansion of the action potential initiation site. Nature Commun  5: 3817, pp 1-12 (link).
  • Pavlov I#, Savtchenko LP, Song I, Koob J, Pimashkin A, Rusakov DA#, Semyanov A# (2014)  Tonic GABAA conductance bidirectionally controls interneuron firing pattern and synchronization in the CA3 hippocampal network. PNAS USA 111: 504-509  (@ corresp; link).
  • Vergnano AM*, Rebola N*, Savtchenko LP*, Pinheiro PS, Casado M, Kieffer BL, Rusakov DA, Mulle C, Paoletti P (2014) Zinc dynamics and action at excitatory synapses. Neuron 82: 1101-14 (link).
  • Rusakov DA, Bard L, Stewart MG, Henneberger C (2014) Diversity of astroglial functions alludes to subcellular specialisation. Trends Neurosci 37: 228-242 (link).
  • Davydova D*, Marini C*, King C, Klueva J, Bischof F, Romorini S, Montenegro-Venegas C, Heine M, Schneider R, Schröder MS, Altrock WD, Henneberger C, Rusakov DA, Gundelfinger ED, Fejtova A (2014) Bassoon specifically controls presynaptic P/Q-type Ca2+ channels via RIM-binding protein. Neuron 82: 181-194 (link).
  • Sylantyev S*, Savtchenko LP*, Ermolyuk Y, Michaluk P, Rusakov DA (2013) Spike-driven glutamate electrodiffusion triggers synaptic potentiation via a Homer-dependent mGluR-NMDAR link. Neuron 77: 528-541 (link) (Neuron Preview link).
  • Sylantyev S*, Jensen TP*, Ross RA, Rusakov DA (2013) Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses. PNAS USA 110: 5193-5198 (link).
  • Savtchenko LP*, Sylantyev S*, Rusakov DA (2013) Central synapses release a resource-efficient amount of glutamate. Nature Neurosci 16: 10-12 (link).
  • Sylantyev S, Rusakov DA (2013) Sub-millisecond ligand probing of membrane receptors with multiple solution exchange. Nature Protocols 8: 1299-1306 (link).
  • Novak P, Gorelik J, Vivekananda U, Shevchuk AI, Ermolyuk YS, Bailey RJ, Bushby AJ, Moss GW, Rusakov DA, Klenerman D, Kullmann DM, Volynski KE, Korchev YE (2013) Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels. Neuron 79: 1067-1077 (link).
  • Henneberger C, Rusakov DA (2012) Monitoring local synaptic activity with astrocytic patch pipettes. Nature Protocols 7: 2171-2179 (link).
  • Ermolyuk YS, Alder FG, Henneberger G, Rusakov DA, Kullmann DM, Volynski KE (2012) Independent regulation of basal neurotransmitter release efficacy by variable Ca2+ influx and bouton size at small central synapses. PLoS Biology 10: e1001396 (pp 1-15, link).
  • Dityatev A, Rusakov DA (2011) Molecular signals of plasticity at the tetrapartite synapse.  Curr Opinion Neurobiol 21: 353-359 (link).
  • Henneberger C, Papouin T, Oliet SHR, Rusakov DA (2010) Long-term potentiation depends on release of D-serine from astrocytes. Nature 463, 232-236 (link). (Nature News and Views).
  • Kochlamazashvili G*, Henneberger C*,  Bukalo O*,  Dvoretskova E,  Lievens OM,  Senkov O, Westenbroek R, Engel AK, Catterall WA, Rusakov DA@, Schachner M, Dityatev A@ (2010) The extracellular matrix molecule hyaluronic acid regulates hippocampal synaptic plasticity by modulating postsynaptic L-type Ca2+ channels. Neuron 67: 116-128 (link). (@ corresp, journal cover).
  • Ruiz A, Campanac E, Scott R, Rusakov DA, Kullmann DM (2010) Presynaptic GABAA receptors enhance transmission and LTP induction at hippocampal missy fiber synapses. Nature Neurosci 13: 431-438 (link).
  • Sylantyev S, Savtchenko LP, Niu Y-P, Ivanov AI, Jensen TP, Kullmann DM, Xiao MY, Rusakov DA (2008) Electric fields due to synaptic currents sharpen excitatory transmission. Science 319: 1845-1849.
  • Lamsa KP, Heeroma JH, Somogyi P, Rusakov DA, Kullmann DM (2007) Anti-Hebbian long-term potentiation in the hippocampal  feedback inhibitory circuit. Science 315: 1262-1266.
  • Savtchenko LP, Rusakov DA (2007) The optimal height of the synaptic cleft. PNAS USA 104: 1823-1828. 

Historical selected 

  • Scott R, Rusakov DA (2006) Main determinants of presynaptic Ca2+ dynamics at individual mossy fiber -CA3 pyramidal cell synapses. J Neurosci 26: 7071-7081.
  • Rusakov DA@, Saitow F, Lehre KP, Konishi S (2005) Modulation of presynaptic Ca2+ entry by AMPA receptors at individual GABAergic synapses in the cerebellum. J Neurosci 25: 4930-4940.
  • Scimemi A, Fine A, Kullmann DM, Rusakov DA (2004) NR2B-containing receptors mediate crosstalk among hioppocampal synapses J Neurosci 24: 4767-4777. 
  • Rusakov DA@, Fine A (2003) Extracellular Ca2+ depletion contributes to fast activity-dependent modulation of synaptic transmission in the brain. Neuron 37: 187-197.
  • Ruiz A, Fabian-Fine R, Scott R, Walker MC, Rusakov DA, Kullmann DM (2003) GABAA receptors at hippocampal mossy fibers. Neuron 39: 961-973.
  • Lehre KP, Rusakov DA (2002) Asummetry of glia bear central synapses favors presynaptically directed glutamate escape. Biophys J 83: 1947-1959. 
  • Rusakov DA, Kullmann DM, Stewart MG (1999) Hippocampal synapses: Do they talk to their neighbours? Trends Neurosci 22:382-388.
  • Min MY, Rusakov DA, Kulmann DM (1998) Activation of AMPA, kainate and metabotrpic receptors at hippocampal mossy fiber synapses: role of glutamate diffusion. Neuron 21: 561-570.
  • Rusakov DA, Kullmann DM (1998) Extrasynaptic diffusion in the hippocampus: ultrastructural constrains, uptake, and receptor activation. J Neurosci 18: 3158-3170.
  • Rusakov DA, Kullmann DM (1998) Geometric and vicsous components of the tortuosity of the extracellular space in the brain. PNAS USA 95: 8975-8980.
  • Rusakov DA, Davies HA, Harrison E, Diana G, Richter-Levin G, Bliss TVP, Stewart MG (1997) Ultrastructural correlates of spatial learning in rat hippocampus. Neurosci 80: 69-77.
  • Hosokawa T, Rusakov DA, Bliss TV, Fine A (1995) Repeated confocal imaging of individual dendritic spines in the living slice: evidence for changes in length and orientation associated with chamically induced LTP. J Neurosci 15: 5560-5573.
  • Rusakov DA (1993) Estimation of the size distribution of closed cell elements from analysis of their random plane secions. Biometrics 49: 141-149.

Other publications: PubMed link