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Prof Louis Lemieux
Professor of Physics Applied to Medicine
Clinical & Experimental Epilepsy
UCL Queen Square Institute of Neurology
- Joined UCL
- 1st Aug 1997
Research summary
Our work's primary focus is on the characterisation, and in particular localisation, of the generators of epileptiform activity and associated brain networks, such as interictal spikes and seizures in patients with epilepsy. We combine structural and functional MR imaging with EEG/MEG and also other imaging techniques. In particular, we use simultaneous EEG and fMRI acquisitions to attempt to study haemodynamic changes linked to spontaneous pathological discharges captured in patients at rest in the scanner. We are developing modelling strategies aimed at predicting the haemodynamic changes based on analysis of the EEG. The ultimate clinical aim is to provide an efficient means of localising brain regions responsible for the seizures.
An important second area of research is the development of new multi-data modal acquisition techniques in particular concurrent invasive EEG and fMRI, with emphasis on safety and data quality issues.
We have recently started investigating brain network alterations in relation to the level of risk of sudden unexplained death in epilepsy (SUDEP).
Teaching summary
I am the coordinator for the "Physical Science module
3: Advanced Imaging” module of the MSc in Advanced Neuroimaging at the UCL
Institute of Neurology. I teach on multimodal and longitudinal imaging in the
same MSc and the Otology and Audiology MSc at the UCL Ear Institute.
Since 2016, I lead an annual short course on "Devices and MR Compatibility".
Education
- University de Montreal
- Doctorate, Doctor of Philosophy | 1989
- University of Toronto
- Other higher degree, Master of Science | 1984
- University de Montreal
- First Degree, Bachelor of Science | 1982
Biography
I studied physics (BSc and PhD) at the Universite de Montreal, Canada and the University of Toronto (MSc). I moved to London to join the Institute of Neurology in January 1990, as part of the newly established Epilepsy Research Group under David Fish and Simon Shorvon, to work on multimodal image data fusion for surgery planning. In 1995 David Fish, Philip Allen and I started a systematic investigation of the safety and data quality issues associated performing simultaneous EEG-fMRI recordings. This work turned out to be the foundation of a continuing research programme.