Dr Jan-Willem Taanman

Research summary

My research focuses mainly on the biogenesis of mitochondria and the role of mitochondria in disease. Historically, I have worked on: (1) structure-function relationships and assembly of the terminal mitochondrial respiratory chain enzyme complex cytochrome-c oxidase, and (2) mitochondrial DNA depletion syndrome. Since 2005, I have also studied mitochondrial aspects in Parkinson’s disease. More recent research projects include: (1) the biogenesis of mitochondrial respiratory chain complex I, (2) the glycolytic switch in the progression of colorectal cancer, (3) the influence of mitochondrial DNA level on cellular energy metabolism, (4) the generation of stem cell models of Parkinson's disease, and (5) the mitochondrial metabolic signature in peripheral tissues of Huntington’s disease patients.

Teaching summary

Supervision of research projects of BSc students (Biochemistry, Biomedical Sciences, Biological Sciences, Biotechnology, Genetics, Human Genetics, Molecular Biology, Physiology) and MSc students (Clinical Neurosciences).

Education

To be updated

, | 1991

To be updated

, | 1985

To be updated

, | 1982

Publications

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