Dr Jan-Willem Taanman
Reader in Clinical Neurosciences
Clinical and Movement Neurosciences
UCL Queen Square Institute of Neurology
- Joined UCL
- 1st Oct 2001
Research summary
My research focuses mainly on the biogenesis of mitochondria and the role of mitochondria in disease. Historically, I have worked on: (1) structure-function relationships and assembly of the terminal mitochondrial respiratory chain enzyme complex cytochrome-c oxidase, and (2) mitochondrial DNA depletion syndrome. Since 2005, I have also studied mitochondrial aspects in Parkinson’s disease. More recent research projects include: (1) the biogenesis of mitochondrial respiratory chain complex I, (2) the glycolytic switch in the progression of colorectal cancer, (3) the influence of mitochondrial DNA level on cellular energy metabolism, (4) the generation of stem cell models of Parkinson's disease, and (5) the mitochondrial metabolic signature in peripheral tissues of Huntington’s disease patients.
Teaching summary
Supervision of research projects of BSc students (Biochemistry, Biomedical Sciences, Biological Sciences, Biotechnology, Genetics, Human Genetics, Molecular Biology, Physiology) and MSc students (Clinical Neurosciences).
Education
- To be updated
- Doctorate, Doctor of Philosophy | 1991
- To be updated
- Other higher degree, Masters | 1985
- To be updated
- First Degree, Bachelor of Science | 1982