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UCL Queen Square Institute of Neurology

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Dr Jan-Willem Taanman

Dr Jan-Willem Taanman

Reader in Clinical Neurosciences

Clinical and Movement Neurosciences

UCL Queen Square Institute of Neurology

Joined UCL
1st Jan 2001

Research summary

My research focuses mainly on the biogenesis of mitochondria and the role of mitochondria in disease. Historically, I have worked on: (1) structure-function relationships and assembly of the terminal mitochondrial respiratory chain enzyme complex cytochrome-c oxidase, and (2) mitochondrial DNA depletion syndrome. Since 2005, I have also studied mitochondrial aspects in Parkinson’s disease. More recent research projects include: (1) the biogenesis of mitochondrial respiratory chain complex I, (2) the glycolytic switch in the progression of colorectal cancer, (3) the influence of mitochondrial DNA level on cellular energy metabolism, (4) the generation of stem cell models of Parkinson's disease, and (5) the mitochondrial metabolic signature in peripheral tissues of Huntington’s disease patients.

Teaching summary

Supervision of research projects of BSc students (Biochemistry, Biomedical Sciences, Biological Sciences, Biotechnology, Genetics, Human Genetics, Molecular Biology, Physiology) and MSc students (Clinical Neurosciences).

Education

To be updated
PhD, Cell Biology and Biochemistry | 1991
To be updated
MAS, Plant Pathology | 1985
To be updated
BSc, Plant Pathology | 1982
Publications