Dr Vincent Magloire

ERUK Research Fellow (Senior Research Fellow)

Clinical & Experimental Epilepsy

UCL Queen Square Institute of Neurology

Joined UCL: 18th Sep 2013

Research summary

A number of interneuron subtypes exist within the brain that inhibit different cellular compartments and cell types and form very different synapses with their post-synaptic targets. My lab is interested in studying the role of these interneuron classes in regulating network activity in neocortical and hippocampal microcircuits, both in physiological and epileptic conditions. To study this, we have developed 2 complementary approaches: (A) In ex-vivo cortical slices, we combine patch-clamp recordings with Cre-Lox technology and a variety of optogenetic tools or fluorescent tags in order to record and manipulate specific groups of interneurons and assess their net inhibitory action on the network. (B) In in vivo awake animals, we apply our findings on interneuron physiology to study their role in epilepsy and design protocols to test whether they can be used to stop seizures. For this, we use a combination of electrocorticogram recordings and either two-photon imaging techniques (GCaMP6, iGluSnFR, iGABASnFR) or closed-loop optogenetic stimulation in animals experiencing experimentally-induced seizures.

Teaching summary

2020 Co-coordinator MSc Clinical Neuroscience module: Applied experimental approaches to studying neuronal circuits in health and disease.

2019 Lecture with Dr Saiful Islam, Topics: Non parametric tests (when to use, types of non-parametric tests).

2016 workshop: Introduction to research on spinal cord circuits, Lycée Francais, London.

2010 Lectures in Neurophysiology, University of Savoie, France

2008 Lectures in Neuroanatomy, University of Savoie, France

2006 – 10 Practical course for medical students on the respiratory system, University of Bern, Switzerland

Biography

Previous and current positions

09/2019 – present Principal Investigator/ ERUK Fellow, UCL Institute of Neurology, UK

09/2013 – 09/2019 Epilepsy research UK / MRC research associate , UCL Institute of Neurology, UK

08/2011 – 08/2013 Swiss National Science Foundation fellowship University of Cambridge, UK 08/2010 – 05/2011 Postdoctoral researcher University of Bern, Switzerland

11/2006 – 07/2010 PhD student University of Bern, Switzerland

Education

2010 PhD Neuroscience University of Bern, Switzerland

2006 MSc Neuroscience University of Lyon, France

2004 BSc Biochemistry University of Lyon, France

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