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UCL Queen Square Institute of Neurology

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Dr Matthew Gegg

Senior Research Associate

Clinical and Movement Neurosciences

UCL Queen Square Institute of Neurology

Joined UCL
1st Jul 2009

Research summary

Mutations in the gene encoding for glucocerebrosidase are the greatest known genetic risk factor for developing Parkinson's disease. Glucocerebrosidase is a lysosomal enzyme involved in sphingolipid metabolism. Impairment of the autophagy-lysosomal pathway is implicated in the accumulation/aggregation of alpha-synuclein and the mitochondrial dysfunction observed in Parkinson's disease. I am investigating the mechanisms by which glucocerebrosidase deficiency contributes to aberrant function of the autophagy-lysosome pathway.

Education

University College London
PhD, Neurochemistry | 1999
University of Bath
BSc Hons, Biochemistry | 1997
Publications