UCL Queen Square Institute of Neurology

Dr James Jepson

Dr James Jepson

Principal Research Fellow

Clinical & Experimental Epilepsy

UCL Queen Square Institute of Neurology

Joined UCL
1st Jun 2014

Research summary

The primary goal of my lab is to use the fruit fly, Drosophila, as a model to understand the molecular and cellular mechanisms of neurological disease, particularly those involving involuntary movements (such as dystonia and dyskinesia) and seizures. To do so, we utilise an array of state-of-the-art techniques, including gene editing, electrophysiology, optical imaging, transcriptomics, and genetic modifier screens. In parallel, we have an interest in characterising novel genes and neural circuits influencing sleep in Drosophila

Teaching summary

Dr. Jepson currently lectures on two MSc courses at UCL: Human Genetics and Clinical Neuroscience. His lectures focus on the importance of Drosophila as a model to understand the mechanistic basis of neurological disease. 


Dr. James Jepson attained his degree from Imperial College (BSc, Biology) and his DPhil from Oxford University. He then undertook post-doctoral research in the US, first at Brown University (studying behavioural roles of RNA editing in Drosophila) and subsequently at Thomas Jefferson University (studying the genetic basis of circadian rhythms and sleep). He started his own laboratory at UCL Queen Square Institue of Neurology in 2014. Since then, his lab has published an array of high-profile studies of novel disease models (Cell Reports, Brain) and the neurogenetic basis of sleep in Drosophila (eLife, Current Biology, Scientific Reports). He was awarded a MRC New Investigator Award in 2017.