Aims

Our goal is to understand the mechanisms of neurological diseases characterised by genetic disorders of synaptic function, and apply this to identify therapeutic targets.

We address the following questions:

• How do combinations of inherited variants in synaptic genes interact to affect synaptic function?
• Can inherited disorders of multiple synaptic genes be recreated in invertebrate models and in neurons derived from patients?
• How does synaptic homeostasis interact with inherited genetic variability in synaptic proteins?
• How do alterations in synaptic function affect the operation of small circuits?
• How can an improved understanding of genetic synaptopathies be harnessed to treat paroxysmal neurological disorders?