Bloomsbury Institute for Intensive Care Medicine



The centre is involved in the following research areas:

1 - Pathophysiology of critical illness

  • mitochondrial dysfunction in critical illness
  • association between autonomic and immune dysfunction and relationship to postoperative complications
  • mechanisms of acute renal injury (P2X7 receptor activation)
  • nitrite reductase activity in sepsis and hypoxaemia

2 - Novel monitoring and diagnostics

  • tissue PO2 monitoring as a marker of local oxygen supply adequacy in shock states
  • NADH redox state as a marker of the adequacy of tissue perfusion
  • novel haemodynamic monitoring parameters using linked oesophageal Doppler ultrasound and blood pressure monitoring
  • novel biomarkers for early detection of sepsis and infection
  • development of a critical illness stress index

3 - Novel interventions

  • long-acting sulphide donor therapy for ischaemia-reperfusion injury
  • beta-blocker therapy in severe sepsis
  • activators of mitochondrial biogenesis to enhance recovery from critical illness
  • CD73 therapy for acute lung injury
  • patient-individualized targeted mobilization

4 - Clinical studies