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The Critical Care Trials team are the clinical research limb of the Division of Critical Care and the Bloomsbury Institute of Intensive Care Medicine. The team are composed of a clinical lead (Dr David Brealey) and 5.3 whole time equivalent research nurses.
The Team aim to attract and deliver a wide portfolio of studies that are pertinent not just to Critical Care but the whole Emergency Pathway. As such they frequently work outside the physical walls of Critical Care recruiting patients across the hospital from the Emergency Department to Day Case Chemotherapy. The last 3 years has seen a marked expansion in trials run, by the end of 2013 they will be running over 10 protocols.
There has been an increase in the number of patients recruited, over 300 patients a year, a 50% increase on 2 year ago. The team are able to execute highly demanding early phase drug trials enabling UCH to frequently top the recruitment tables or be the only UK site to deliver the trial.
The Team receive support from the CBRC and thus prioritise Experimental Medicine projects and UCL investigators. Their work on the iPAT study enabled a successful NIHR grant application of £2.1m, whilst the Faron study enabled Dr Bellingan to gain a €6m FP7 grant to develop the drug further. The table below outlines their activity since 2010.
|
Trial (phase of drug development) |
Interventional/ observational | Description |
UCL Chief Investigator |
Trial delivery |
|
Faron (IMP phase 1/2) |
Interventional | IFN-β in acute lung injury | Geoff Bellingan (Critical Care) | Finished 2012 |
|
Zanamavir (IMP phase 2) |
Interventional | Intravenous zanamavir in severe influenza-A |
External |
Finished 2012 |
|
OSCAR |
Interventional |
Conventional vs High frequency oscillatory ventilation in acute respiratory distress syndrome |
External |
Finished 2012 |
|
OASIS (IMP phase 2) |
Interventional |
Human recombinant lactoferrin in severe sepsis |
Mervyn Singer (Critical Care) | Finished 2011 |
|
GAINS |
Observational |
Genomics in sepsis | External | Finished 2013 |
|
Oral health |
Observational |
Changes in oral health associated with critical illness |
Ian Needleman (Eastman Dental) | Finished 2012 |
|
iPAT |
Observational |
Validation of a psychological questionnaire in the critically ill |
Dorothy Wade (Critical Care) |
Finished 2012 |
| Immune modulators in early sepsis |
Pre-symptomatic detection of sepsis |
Mervyn Singer (Critical Care) | On going | |
|
ProMISe |
Interventional |
Early goal directed therapy in severe sepsis |
Mervyn Singer (Critical Care) |
On going |
|
CALORIES |
Interventional |
Early enteral vs parenteral nutrition in critical illness |
Monty Mythen (Critical Care) | On going |
|
SPOTid |
Observational | Trajectory of critical illness | Mervyn Singer (Critical Care) | On going |
|
PREVENTT (IMP phase 3) |
Interventional | Intravenous iron in the pre-operative surgical patient |
Toby Richards (Vascular Surgery) |
On going |
|
CAP-ARDS |
Observational |
Role of proteinases in the acute respiratory distress syndrome |
Rachel Chambers (Respiratory Medicine) |
On going |
|
SUDDICU cohort |
Observational |
To determine enrolment rates and powering of a study of selective decontamination of the gut in critical illness |
External | On going |
|
Stress |
Observational | Physical and psychological stressors in critical care | Mervyn Singer (Critical Care) | On going |
|
RADICAL |
Observational |
Validation of a rapid pathogen detection system | Mervyn Singer (Critical Care) | Start November 2013 |
|
HALT-IT (IMP phase 3) |
Interventional |
Intravenous tranexamic acid in severe GI bleeding |
External |
Start November 2013 |
|
Pelorus |
Observational |
Determination of residual blood propofol following prolonged infusions |
David Brealey (Critical Care) |
Start November 2013 |
|
CIGMA (IMP phase 2) |
Interventional | Intravaenous IgM in severe community acquired pneumonia | Mervyn Singer (Critical Care) | Start December 2013 |
|
SOAPBOX |
Observational | First in man validation of novel device to measure bladder oxygen tension as a marker of organ perfusion |
Mervyn Singer (Critical Care) |
Start 2014 |
|
Proxima |
Observational | Validation of an in-line blood gas analyzer |
External |
Start 2014 |