Professor Greg Towers
Professor of Molecular Virology
Research in the Towers lab focusses on understanding the molecular details of host-virus interactions, to develop novel therapeutic approaches for viral infection and to use viruses to help understand mammalian cell biology and evolution.
Our work aims to understand the molecular details of host virus interactions. We focus on human immunodeficiency virus type 1, the cause of AIDS in humans, and SARS-CoV-2, the cause of COVID-19, and their relationship with the innate immune system.
- Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, Leo C. James. HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis. Nature. 2016;536:349-353
- Fletcher AJ, Christensen DE, Nelson C, Tan CP, Schaller T, Lehner PJ, Sundquist WI, Towers GJ. TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription. EMBO J. 2015;34:2078-95
- Rasaiyaah J, Tan CP, Fletcher AJ, Price AJ, Blondeau C, Hilditch L, Jacques DA, Selwood DL, James LC, Noursadeghi M, Towers GJ. HIV-1 evades innate immune recognition through specific co-factor recruitment. Nature. 2013;503:402-405.
A full list of publications can be accessed via Google Scholar.