Welcome to the Towers Lab





We aim to understand the molecular details of host virus interactions, to develop novel therapeutic approaches for viral infection and to use viruses to help us understand mammalian cell biology and evolution.


                                         

John Wlater and HIV capsid at the Edinburgh Sculpture Workshop February 2017. Photo courtesy of James Glossop.

An exploding virus and a model HIV capsid are displayed by John Walter, our artist in residence in Infection, at the Edinbrugh Sculpture Workshop.




Wellcome Trust Senior Fellow

ERC Advanced Investigator

News

Read more about the Towers lab news on our News page.



EMBO J publication, Jan 2017

Synopsis of Mlcochova et al, EMBO 2017. Here, we show that macrophages are found in both G0‐ and G1‐like phases, and the latter are permissive to HIV‐1 due to the canonical Raf/MEK/ERK pathway which deactivates SAMHD1 by CDK1‐mediated phosphorylation at T592. Therefore, HIV‐1 does not need to encode a SAMHD1 antagonist.

Dr Petra Mlcochova from our colaborators, the Gupta group, has had her paper 'A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages' published in EMBO J.



Dr Doug Fink visits the Nigerian Institute of Medical Research, Dec 2016

Dr Doug Fink and Dr Oseme Etomi visiting the Nigerian Institute of Medical Research in Lagos, Nigeria.

Dr Doug Fink and Dr Oseme Etomi at the Nigerian Institute of Medical Research in Lagos, Nigeria as part of a visit supported by the UCL Development Fund.



Recent Publications, 2016

Nature

Our collaborative work with Dr Leo James has been published in Nature.

David A. Jacques, William A. McEwan, Laura Hilditch, Amanda J. Price, Greg J. Towers, Leo C. James. HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis. Nature. 2016 Aug 18;536(7616):349-53

Journal of Virology

We have also recently published with Dr Julia García Pradoin Journal of Virology.

Jimenez E, Ruiz A, Kløverpris HN, Rodriguez-Plata MT, Peña R, Blondeau C, Selwood DL, Izquierdo-Useros N, Moris A, Clotet B, Goulder P, Towers GJ, Prado JG. Non-human TRIM5 variants enhance recognition of HIV-1-infected cells by CD8+ T cells. (J Virol. 2016 Jul 20. pii: JVI.00819-16. [Epub ahead of print] PMID: 27440884),

Journal of Biological Chemistry

We have published with Prof David Selwood in Journal Of Biological Chemistry.

Warne J, Pryce G, Hill JM, Shi X, Lennerås F, Puentes F, Kip M, Hilditch L, Walker P, Simone MI, Chan AW, Towers GJ, Coker AR, Duchen MR, Szabadkai G, Baker D, Selwood DL. Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis (J Biol Chem. 2016 Feb 26;291(9):4356-73. doi: 10.1074/jbc.M115.700385. Epub 2015 Dec 17. PMID: 26679998).



BSc results, July 2016

Mei and Elysia

Congratulations to our summer students Meiyin Lin (UCL) and Elysia Upton (Imperial College London) who achieved firsts in their BSc degrees.



Postdoctoral Vacancies, July 2016

We will soon be advertising for 2 Research Associates for posts funded by a Wellcome Trust Senior Fellowship entitled “Characterisation of innate immune DNA sensing and viral evasion strategies”. Check back for more information in late August/early September or go to our recruitment page.



Cold Spring Harbor Retrovirus Meeting, May 2016

Rich Miles defends his poster

The Towers Lab attended the Retrovirus meeting at Cold Spring Harbor.



The Towers lab presented posters at Keystone, March 2016 

MariaT presents her poster at Keystone conference 2016

MariaT, Becky, Lucy and Greg attended the 2016 Keystone conference on HIV Persistence: Pathogenesis and Eradication (X7) at Squaw Creek - Olympic Valley, California, USA. MT and Greg presented posters.



Richard Miles has secured a fellowship to go to New York, Jan 2016

Richard has secured the Charlotte and Yule Bogue Research Fellowship to visit the lab of Professor Singer in New York.



Dr Doug Fink wins funding for his PhD, Jan 2016

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Doug has secured a Wellcome Trust Clinical Research Training Fellowship at UCL.



Towers Lab Christmas do, Dec 2015

Towers lab Christmas do at 'Watch Me'. Alun Vaughan-Jackson, Chris Monit, Chris Tie, Kat Sutherland, Lucy Thorne, Dami Collier, Teresa Rodriguez-Plata, isobel Honeyborne, Claire Kerridge, Carolina Ferreira, Jane Rasaiyaah, Calire Pardieu, Stephane Hue, Jane Turner, Greg Towers, Ecco Staller, Doug King, Doug Fink, Jade Donovan, Hataf Khan, Choon Ping Tan, David Stirling, Jo Rowley, Dejan Mesner, Clare Jolly, Laura Hilditch, Richard Miles, Petra Mlcochova

The Towers lab and friends took their annual curry pilgrimage to 'Watch Me' in South Wimbledon for Christmas.









We are funded by Senior Biomedical Research Fellowship from the Wellcome Trust No 090940 to Professor Greg Towers and also by: a European Research Council Advanced Award, a Medical Research Council confidence in concept award, a UCL Business proof of concept award, the National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre and the UCL MRC Centre for Medical Molecular Virology.


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Page last modified on 08 feb 17 10:43 by Jane Lorna Elizabeth Turner