Division of Infection and Immunity


IIT Virtual Seminar | Dr Gillian Tomlinson

10 December 2020, 12:00 pm–1:00 pm

'Human and zebrafish models to identify determinants of outcome in tuberculosis'

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Dr Anne Pesenacker

Dr Gillian Tomlinson (Division of Infection and Immunity, UCL) will be speaking at the UCL Institute of Immunity and Transplantation Seminar Series on Thursday 10 December. The seminar will be held virtually over Microsoft Teams.

All are welcome to attend. Please contact Fran Jackson (f.jackson@ucl.ac.uk) if you would like to join the seminar, or meet the speaker.

About the speaker

Differences in the immune response to tuberculosis make a major contribution to clinical outcome, and evidence suggests that the best responses require inflammation to kill the bacteria, balanced by regulation to avoid pathology, but the molecular mechanisms that control this are unclear.

The Tomlinson Lab integrates a cutting-edge human experimental tuberculosis challenge model with studies using zebrafish to identify and validate host factors that calibrate a favourable immune response in tuberculosis. The zebrafish Mycobacterium marinum infection model provides a natural host-pathogen interaction with granulomatous inflammation that is an excellent model of human tuberculosis. Moreover, zebrafish larvae are optically transparent allowing us to visualise bacterial growth and cellular responses to infection.

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