Dr Gillian Tomlinson
MRC Clinician Scientist
Research in the Tomlinson lab focusses on improving understanding of the molecular determinants of both protective and pathogenic immune responses in tuberculosis, to inform development of novel treatments and vaccines and new ways to stratify risk of active disease.
Differences in the immune response to tuberculosis make a major contribution to clinical outcome, and evidence suggests that the best responses require inflammation to kill the bacteria, balanced by regulation to avoid pathology, but the molecular mechanisms that control this are unclear.
We integrate a cutting-edge human experimental tuberculosis challenge model with studies using zebrafish to identify and validate host factors that calibrate a favourable immune response in tuberculosis. The zebrafish Mycobacterium marinum infection model provides a natural host-pathogen interaction with granulomatous inflammation that is an excellent model of human tuberculosis. Moreover, zebrafish larvae are optically transparent allowing us to visualise bacterial growth and cellular responses to infection.
We collaborate closely with Dr Mahdad Noursadeghi's and Professor Benny Chain's groups which study host immune responses to infectious diseases at genome‑wide level with a particular focus on tuberculosis.
- Bell LC, Pollara G, Pascoe M, Tomlinson GS, Lehloenya RJ, Roe J, Meldau R, Miller RF, Ramsay A, Chain BM, Dheda K, Noursadeghi M. In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis. PLoS Pathog. 2016;12:e1005469
- Tomlinson GS, Thomas N, Chain BM, Best K, Simpson N, Hardavella G, Brown J, Bhowmik A, Navani N, Janes SM, Miller RF, Noursadeghi M. Transcriptional Profiling of Endobronchial Ultrasound-Guided Lymph Node Samples Aids Diagnosis of Mediastinal Lymphadenopathy. Chest. 2016;149:535-544
- Jarvis JN, Meintjes G, Bicanic T, Buffa V, Hogan L, Mo S, Tomlinson G, Kropf P, Noursadeghi M, Harrison TS. Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis. PLoS Pathog. 2015;11:e1004754
- Tomlinson G, Chimalapati S, Pollard T, Lapp T, Cohen J, Camberlein E, Stafford S, Periselneris J, Aldridge C, Vollmer W, Picard C, Casanova JL, Noursadeghi M, Brown J. TLR-mediated inflammatory responses to Streptococcus pneumoniae are highly dependent on surface expression of bacterial lipoproteins. J Immunol. 2014;193:3736-45
- Tomlinson GS, Bell LC, Walker NF, Tsang J, Brown JS, Breen R, Lipman M, Katz DR, Miller RF, Chain BM, Elkington PT, Noursadeghi M. HIV-1 infection of macrophages dysregulates innate immune responses to Mycobacterium tuberculosis by inhibition of interleukin-10. J Infect Dis. 2014;209:1055-65
- Tomlinson GS, Booth H, Petit SJ, Potton E, Towers GJ, Miller RF, Chain BM, Noursadeghi M. Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation. PLoS One. 2012;7:e40348
- Tomlinson GS, Cashmore TJ, Elkington PT, Yates J, Lehloenya RJ, Tsang J, Brown M, Miller RF, Dheda K, Katz DR, Chain BM, Noursadeghi M. Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test. Eur J Immunol. 2011;41:3253-60.
A full list of publications can be accessed via PubMed.