UCL Institute of Clinical Trials and Methodology


Methods of Analysis for Different Estimands

Date: 5th June 2024
Timings: 10:00 - 17:00

Location: MRC Clinical Trials Unit at UCL, 90 High Holborn, London

Register Interest

Estimands are becoming widely used in randomised trials. This MRC-NIHR-TMRP funded course covers the statistical methods that can be used to estimate different estimands. We will cover methods for each intercurrent event strategy (treatment policy, composite, while-on-treatment, principal stratum, and hypothetical), and provide practical examples along with statistical code in Stata and R to implement the different estimators.


  • Brennan Kahan, MRC Clinical Trials Unit at UCL
  • Suzie Cro, Imperial Clinical Trials Unit
  • Ian White, MRC Clinical Trials Unit at UCL
  • Richard Emsley, Kings Clinical Trials Unit
  • Darren Dahly, HRB Clinical Research Facility – University College Cork
  • Tra My Pham, MRC Clinical Trials Unit at UCL
  • Beatriz Goulao, Health Services Research Unit, University of Aberdeen

Course aims

By the end of this workshop, participants will understand:

  • The interpretation of the different intercurrent event strategies
  • Which estimators can be used for different intercurrent event strategies, along with their assumptions
  • How to choose between different estimators for a given trial
  • How to implement the estimators in Stata or R

Target audience

  • Applied statisticians working on randomised trials

Software required

All participants will need their own laptop running a recent version of either Stata or R.


The course is free. However, it is likely to be oversubscribed, in this case the attendees will be selected based on their registration.