I studied at the University of Lausanne in Switzerland and obtained a Masters and PhD from the same institution in 1996, and 2000, respectively. After a brief stay at the University of Bern, I moved to Edinburgh, first as a postdoctoral research associate and then as a postdoctoral fellow. I was offered a lectureship in the Department of Genetics in Cambridge in 2002. I built up a successful research group and stayed there for five years. In 2007, I left Cambridge to join the newly formed MRC Centre for Outbreak Analysis and Modelling within the Department of Infectious disease epidemiology at Imperial College London. I again spent five years there as a Reader there and moved to UCL in 2012 to become professor of Computational Systems Biology. My primary research interest is to use genomic data to answer important fundamental and applied questions in biology and medicine. My research lies at the interface between genomics, epidemiology, evolution and ecology. Over recent years most of my work has focused on human and wildlife pathogens. In addition to reconstructing disease outbreaks and epidemics in space and time for a variety of pathogens, I have become interested in understanding the factors that allow certain lineages to outcompete others. One such factor which is of particular interest is the acquisition and maintenance of antimicrobial resistance in pathogenic bacteria.