UCL Division of Biosciences


Sharon Boast

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I am the Laboratory Manager of Stern Lab in the UCL Research Department of Cell & Developmental Biology.

Telephone (Office): 020 3108 4045 

Email: s.boast@ucl.ac.uk


  • Lania, L., Boast, S. and Fried, M. (1982) Excisionof polyoma virus genomes from chromosomal DNA by homologous recombination. Nature 295: 349-350.
  • Boast, S., La Mantia, G., Lania, L. and Blasi, F. (1983) High efficiency of replication and expression of for­eign genes in SV40-transformed human fibrob­lasts. EMBO 2: 2327-2331.
  • Riccio, A., Grimaldi, G., Verde, P., Sebastio, G., Boast, S. and Blasi, F. (1985) The human urokinase plasminogen activator gene and its promoter. Nucleic Acids Research 13:2759-2771
  • Riccio, A., Grimaldi, G., Verde, P., Sebastio, G., Boast, S. and Blasi, F. (1985) The structure of the human plasminogen activator (uPA) gene. In: Protides of the Biological Fluids, ed. H. Peeters, 33: 67-70, Pergamon Press.
  • Verde, P., Boast, S., Franze', A., Robbiati, F. and Blasi, F. (1988) An upstream enhancer and a negative element in the 5'-flanking region of the human urokinase plasminogen activator gene. Nucleic Acids Research 16: 10699-10716.
  • Ramirez F., Boast S., D'Alessio M., Su M.W., Vissing H. and Yoshioka H. (1989) Molecular pathobiology of human collagenopathies. In: The Chemistry and Biology of Mineralized Tissues, ed. Glimcher M.J. and Rodan G.A. Gordon and Breach Publ. 21: 79-89.
  • Ramirez F., Boast S., D'Alessio M., Lee B., Prince J., Su M.W., Vissing H. and Yoshioka H. (1990) Fibril­lar collagen genes; structure and expression in normal and diseased states. In: Structure, Molecular Biology and Pathology of Collagens. Ann. N Y Acad Science. Ed. Fleischman R., Olsen B.R., Kuhn K. 580: 74-80.
  • Parker M.I., Smith A.A., Boast S., Su M.W. and Ramirez F. (1990) Regulation of the Human COLIA2 Gene by a Trans -acting factor. In:Structure,Molecular Biology and Pathology of Collagens.Ann. N.Y.Acad Science.Ed.Fleischman R,Olsen B.R.Kuhn K. 580:
  • Boast S., Su M.W., Ramirez F., Sanchez M. and Avvedimento V.E. (1990) 'Functional analysis of cis-acting DNA sequences controlling transcription of the hu­man type1 collagen genes. Journal of Biological Chemistry 265: 13351-13356.
  • Schwartzberg P.L., Stall A.M., Hardin J.D., Bowdish K.S., Humaran T., Boast S., Harbison M.L., Robertson E.J. and Goff S.P. (1991) Mice Homozygous for the ablm1 Mutation Show Poor Viability and Depletion of Selected B and T Cell Populations. Cell 65: 1165-1175.
  • Parker M.I., Smith A.A., Mundell K., Collins M., Boast S. and Ramirez F. (1992) 'Evidence for a Negative Trans-acting Factor Repressing a2 Collagen Gene Expression. Nucleic Acids Research 20: 5825-5830
  • Wong, K.K., Hardin, J.D., Boast S., Cooper, C.L., Merrell, K.T., Doyle, T.G., Goff, S.P., and Calame, K.L. (1995) A role for c-abl in c-myc regulation. Oncogene 10: 705-711
  • Mackarehtschian, K,, Hardin, J.D., Moore K.A., Boast, S., Goff S.P., and Lemischka, I.R. (1995) Targeted disruption of the flk2/flt 3 gene leads to deficiencies in primitive hematopoitic progenitors. Immunity 3: 147-161
  • Hardin, J.D., Boast, S., Schwartzberg P.L., Lee, G., Alt, F.W., Stall A.M. and Goff, S.P. (1995) Bone marrow B Lymphocyte development in c-abl deficient mice. Cellular Immunology 165: 44-54
  • Hardin, J.D., Boast S., Mendolsohn, M., DeLosSantos, K., and Goff, S.P. (1996) Transgenes encoding both Type I and Type IV c-abl proteins rescue the lethality of c-abl mutant mice. Oncogene 12: 2669-2677
  • Hardin, J.D., Boast, S., Schwartzberg, P.L., Lee, G., Alt, F.W., Stall, A.M., and Goff, S.P. (1996) Abnormal peripheral lymphocyte function in c-abl mutant mice. Cellular Immunology 172: 100-107
  • Zhang, Q.K., Boast, S., DeLosSantos, K., Begemann, M., and Goff, S.P. (1996) Transforming activity of retroviral genomes encoding gag-axl fusion proteins. Journal of Virology Nov: 8089-8097
  • Lu, Q., Gore, M., Zhang, Q. ,Camenisch, T. Boast, S. Casagrande, F. Lai, C., Skinner, M.K., Klein, R., Matsushima, H., Earp, H.S., Goff, S.P., Lemke, G. (1999) Recepor tyrosine kinases of the Tyro 3 family are essential regulators of mammalian spermatogenesis. Nature 398: 723-728
  • S. Boast*, B. Li*, K. de los Santos, I. Schieren, M. Quiroz, S. L. Teitelbaum, M. Tondravi, and S.P. Goff. (2000) c-Abl knockout mice are osteoporotic and show defects in osteoblast maturation. Nature Genetics 15: 304-308 *Equal contribution.
  • Li, B., Wang, X., Rasheed,N., Hu,Y., Boast,S., Ishii,T., Nakayama,K., Nakayama,K.L. and S.P.Goff (2004) Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C. Genes and Development 18: 1824-1837
  • Lavial, F., Aclocque, H., Bertocchini, F., Macleod, DJ., Boast, S., Bachelard, E., Montillet, G., Thenot, S., Sang, HM., Stern, CD., Samarut, J., Pain, B. (2007) The Oct4 homologue PouV and Nanog regulate pluripotency in chicken embryonic stem cells. Development. 2007 Oct;134 (19):3549-63
  • Papanayatou, C., Mey, A., Birot, AM., Saka, Y., Boast, S., Smith, JC., Samarut, J., Stern, CD. (2008) A mechanism regulating the onset of Sox2 expression in the embryonic neural plate. PloS Biol. 2008 Jan; 6(1): e2