Dr Hyung Chul Lee

I am a postdoctoral research associate in the department of Cell and Developmental Biology, UCL. My project aims to investigate mechanisms of establishment of polarity in the early chick embryo regarding initiation of gastrulation. Before I came here, during my Ph.D. in Seoul National University in Korea, I studied the origin of primordial germ cells and intrauterine stage embryos in chicken. While I looked into cleavage-stage chick embryos under the microscope, I was fascinated by them. And it led me to study embryology in here now. Telephone (Office): 020 3108 4045 E-mail: hyung.lee@ucl.ac.uk

Profile

2004-2008 B.S. Animal Biotechnology, Seoul National University, Korea.
2008-2014 Ph.D. Animal Biotechnology, Seoul National University, Korea.
2014-2015 Senior Researcher. Department of Agricultural Biotechnology, Seoul National University, Korea.
2015-present Postdoctoral research associate, Cell and Developmental Biology, University College London. UK

Publications

• Lee HC, Lim S, Han JY. 2016. Wnt/β-catenin signaling pathway activation is required for proliferation of chicken primordial germ cells in vitro. Sci Rep. 6:34510. Pubmed
• Lee HJ, Lee HC, Kim YM, Hwang YS, Park YH, Park TS, Han JY. 2016. Site-specific recombination in the chicken genome using Flipase recombinase-mediated cassette exchange. FASEB J. 30(2):555-63. Pubmed
• Lee HC, Choi HJ, Lee HG, Lim JM, Ono T, Han JY. 2016. DAZL Expression Explains Origin and Central Formation of Primordial Germ Cells in Chickens. Stem Cells Dev. 25(1):68-79. Pubmed
• Lee HJ, Lee HC, Han JY. 2015. Germline Modification and Engineering in Avian Species. Mol Cells. 38(9):743-9. Pubmed
• Kang KS, Park TS, Rengaraj D, Lee HC, Lee HJ, Choi HJ, Mizushima S, Ono T, Han JY. 2015. Fertilisation of cryopreserved sperm and unfertilised quail ovum by intracytoplasmic sperm injection. Reprod FertilDev. doi: 10.1071/RD15126. Pubmed
• Choi HJ, Lee HC, Kang KS, Lee HG, Ono T, Nagai H, Sheng G and Han JY. 2015. Production of interspecific germline chimeras via embryo replacement. Biol Reprod. 93(2):36. Pubmed
• Nagai H, Sezaki M, Kakiguchi K, Nakaya Y, Lee HC, Ladher R, Sasanami T, Han JY, Yonemura S, Sheng G. 2015. Cellular analysis of cleavage-stage chick embryos reveals hidden conservation in vertebrate early development. Development. 142(7):1279-86. Pubmed
• Kang KS*, Lee HC*, Kim HJ, Lee HG, Kim YM, Lee HJ, Park YH, Yang SY, Rengaraj D, Park TS and Han JY. 2015. Spatial and temporal action of chicken primordial germ cells during initial migration. Reproduction. 149: 179-187. * equal contribution Pubmed
• Han JY, Lee HC, Park TS. 2015. Germline-competent stem cell in avian species and its application. Asian J Androl. 17:421-6. Pubmed
• Lee HC, Kim SK, Park TS, Rengaraj D, Park KJ, Lee HJ, Park SB, Kim SW and Han JY. 2013. Compensatory proliferation of endogenous chicken primordial germ cells after elimination by busulfan treatment. Stem Cell Research & Therapy. 4:136
  Lee HC, Choi HJ, Park TS, Lee SI, Kim YM, Rengaraj D, Nagai H, Sheng G, Lim JM and Han JY. 2013. Cleavage events and sperm dynamics in chick intrauterine embryos. PLoS One. 8(11):e80631. Pubmed
• Jeong W, Lim W, Kim J, Ahn SE, Lee HC, Jeong JW, Han JY, Song G, Bazer FW. 2012. Cell-specific and temporal aspects of gene expression in the chicken oviduct at different stages of the laying cycle. Biol Reprod. 86(6):172-180. Pubmed
• Lee SI, Lee BR, Hwang YS, Lee HC, Rengaraj D, Song G, Park TS, Han JY. 2011. MicroRNA-mediated posttranscriptional regulation is required for maintaining undifferentiated properties of blastoderm and primordial germ cells in chickens. Proc Natl Acad Sci U S A. 108(26):10426-10431. Pubmed
• Kang SJ, Sohn SH, Kang KS, Lee HC, Lee SK, Choi JW, Han JY. 2011. Molecular and biological aspects of early germ cell development in interspecies hybrids between chickens and pheasants. Theriogenology. 75:696-706. Pubmed
• Park KJ, Kang SJ, Kim TM, Lee YM, Lee HC, Song G, Han JY. 2010. Gamma-irradiation depletes endogenous germ cells and increases donor cell distribution in chimeric chickens. In Vitro Cell Dev Biol Anim. 46(10):828-833. Pubmed
• Lee SI, Kim JK, Park HJ, Jang HJ, Lee HC, Min TS, Song GW, Han JY. 2010. Molecular cloning and characterization of the germ cell-related nuclear orphan receptor in chickens. Mol Reprod Dev. 77(3):273-284. Pubmed

Conferences and Meetings (from 2013)

• SSR's (Society for the Study of Reproduction) 46th Annual Meeting .Montreal, Canada. 2013. Physiological Polyspermy and Cleavage Patterns in Chick Intrauterine Embryos.
• AVIAN GERMPLASM FORUM. Seoul, Korea. 2013 Sperm dynamic during intrauterine embryo development and tracing of origin of germ cells by DAZL expression.
• CSHL Conference on Avian Model Systems. CSHL, USA, 2014. Development of Primordial Germ Cells in Chicken.
• The 10th Asia Pacific Poultry Conference. Jeju, Korea, 2014. Origin and Development of Chicken Primordial Germ Cells.