Welcome to the RNAP Lab
Finn Werner, PhD
Principle Investigator and Senior Lecturer
Room 308, Darwin Building,
UCL, Gower Street
T: 020 7679 0147
Important regulatory events in the cell occur at the level of transcription, which is facilitated by RNA polymerases (RNAPs). Our research focuses on the workings of the archael RNAP, a superb and biochemically tractable model system for eukaryotic RNAPII. We make use of a recombinant transcription system that allows us to introduce mutations chemically reactive or fluorescent probes into RNAP variants in a range of sopisticated biochemical and biophysical assays. This functional dissection strategy of RNAP illuminates the function of the RNAP and its interplay with transcription factors - ultimately explaining gene expression at the atomic level.
Apart from supervising postgraduate students in our laboratory, I teach Biochemistry for 1st year students (Bioc 1007), Molecular Biology for 2nd year (Bioc 2001) and 3rd year students (Bioc 3004), and I'm the organiser for the flagship course of our department, "Advanced Biomolecular Mechanisms" (Bioc 3003/6), which is aimed at both 3rd year undergraduates and 1st year PhD students.
If you are interested in obtaining a PhD studentship in my lab please apply via this link: