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Guest Speaker Jenny Gallop

Regulating the Actin Cytoskeleton: The Role of Membrane Environment

Event Host : Buzz Baum

Speaker's affiliation Wellcome Trust Career Development Fellow, Member of the Department of Biochemistry,University of Cambridge

Monday, 7 September, 2015 - 16:00
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Group Leader Spotlight

G protein coupled receptor (GPCR) signaling

G-protein-coupled receptors (GPCRs) represent the largest family of cell surface receptors. They share a common 7 transmembrane domain configuration and act to transduce extracellular stimuli to the interior of the cell. GPCRs are expressed in virtually every cell type and modulate an extremely wide range of physiological processes. They represent a rich source of targets for the pharmaceutical industry with approximately 30-50% of current pharmaceuticals targeting these proteins. Following repeated or continuous exposure to agonists GPCRs exhibit diminished responsiveness, a phenomenon termed receptor desensitisation. For many GPCRs rapid desensitisation is mediated by a family of serine/...

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