Actin in cell and tissue morphogenesis
Current research - outline
The dynamic shape of an animal cell is determined by the interplay of intra- and extracellular forces. In the lab we explore the molecular, cellular and physical processes involved using interdisciplinary approaches including molecular biology, genetics, high-content RNA interference (RNAi)
screening, live cell imaging, automated image analysis, microfabrication,
biophysical techniques and computational modeling. The aim of our research is to better
understand how these processes contribute to normal tissue development and homeostasis and, when they go awry, to the evolution of metastatic cancer.
Cancer and the importance of mitotic cell rounding...