TOBY Xenon Study

Neuroprotective effects of Hypothermia combined with inhaled xenon following perinatal asphyxia

This is a proof-of-concept study to test the hypothesis that following perinatal asphyxia treatment with a combination of hypothermia and inhaled xenon reduces cerebral biochemical abnormality, preserves cerebral structures, and leads to improved clinical outcomes at hospital discharge.

There are three London centres participating in this trial: University College Hospital, St Thomas’s Hospital, Queen Charlotte’s Hospital.

The team at UCL

PI: Nicola Robertson
Mary Dinan, Advanced neonatal neurology nurse practitioner
Dr Giles Kendall, Consultant Neonatologist
Dr Cristine Uria, Research Fellow (PhD student)
Dr Alan Bainbridge, MR physicist
Mr David Price, MR physicist

For more information on the TOBY Xe trial:
www.npeu.ox.ac.uk/toby-xe

References

Azzopardi D, Robertson NJ, Kapetanakis A, Griffiths J, Rennie JM, Mathieson SR, Edwards AD. Anticonvulsant effect of xenon on neonatal asphyxial seizures. Arch Dis Child Fetal Neonatal Ed. 2013 Apr 9.