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Publications

Original Publications 

  1. Cauldwell M, Bredaki E, Dassan P, Dhanjal M, Kaler M, Madipola N, Mahmud M, Paviour D, De Silva R, Senvar N, Watt-Coote I, Williams D, Yulia A, Steer P.  Maternal and fetal outcomes in women with cerebrovascular malformations in pregnancy: a multicentre retrospective cohort study. BJOG: Int J Obstet Gy. 2021; 00: 1–7. https://doi. org/10.1111/1471-0528.17046
  2. Scott R, Parker H, McCartney S, Harrow P, Williams D, Giles I. Outcomes following Biosimilar TNF Inhibitors use for Inflammatory Mediated Immune Disorders in Pregnancy. Obstetric Medicine 2021
  3. Dolma P, Angchuk PT, Vandana J, Dadhwal V, Kular D, Williams DJ, Montgomery HE, Hillman SL.  High-altitude population neonatal and maternal phenotypes associated with birthweight protection. Pediatric Research 2021 https://doi.org/10.1038/s41390-021-01593-5
  4. Åsenius F, Gorrie-Stone TJ, Brew A, Panchbhaya Y, Williamson E, Schalkwyk LC, Rakyan VK, Holland ML, Marzi SJ, Williams DJ. The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations. PLoS Genetics 2020 16(10): e1009035. https://doi.org/10.1371/journal.pgen.1009035
  5. Thaventhiran JED, Lango-Allen H, Burren OS et al. Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature 2020 May 6; 10.1038/s41586-020-2265-1. (As member of Primary Immunodeficiency Consortium for the NIHR Bioresource)
  6. Bos M, Harris-Mostert E.T.M.S, van der Meeren L.E, Baelde J.J, Williams D.J, Nikkels P.G.J, Bloemenkamp K.W.M, van der Hoorn M.L.P. Clinical outcomes in chronic intervillositis of unknown etiology. Placenta 2020; 91: 19-23
  7. Serrano NC, Quintero-Lesmes DC, Dudbridge F, Leon LJ, Hingorani AD, Williams DJ, Casas JP. Family History of Pre-Eclampsia and Cardiovascular Disease as risk factors for Pre-Eclampsia: the GenPE Case-Control Study. Hypertension in Pregnancy 2020; 39: 56-63
  8. Ahmed AS*, Williams DJ*, Cheed V, Middleton L, Ahmad S, Wang K, Vince AT, Hewett P, Spencer K, Khan KS, Daniels JP for the StAmP trial collaborative group. Pravastatin for early-onset preeclampsia: a randomized, blinded, placebo-controlled trial. BJOG: An International Journal of Obstetrics & Gynaecology 2020; 127: 478-488 (*Equal contribution)
  9. Serrano N, Guio E, Herrera VM, Becerra SM, Paez MC, Beltran MA, Leon LJ, Quintero-Lesmes D, Williams D, Casas JP. Lipid profile, plasma apolipoproteins and pre-eclampsia risk in the GenPE case-control study. Atherosclerosis 2018; 276: 189-194
  10. Mouyis MA, Thornton CC, Williams D, Giles IP. Pregnancy outcomes in patients with psoriatic arthritis. Rheumatology 2017; 44: 128-129
  11. Hillman SL, Kubba T, Williams DJ. Delivery of a growth-restricted offspring and the association with early-onset impaired maternal endothelial function. Ultrasound in Obstetrics & Gynecology 2017; 49: 150-154.
  12. Nadkarni S, Smith J, Sferruzzi-Perri AN, Ledwozyw A, Kishore M, Haas R, Mauro C, Williams DJ, Farsky SHP, Marelli-Berg FM, Perretti M. Neutrophils induce pro-angiogenic T cells with a regulatory phenotype in pregnancy. Proceedings of the National Academy of Sciences of the USA (PNAS) 2016; 113 (52): E8415-E8424.
  13. Flint J et al. BSR & BHPR guideline on prescribing drugs in pregnancy and breastfeeding. Part I: Standard and biologic disease modifying anti-rheumatic drugs and corticosteroids. Rheumatology 2016; 55 (9): 1693-7.
  14. Flint J et al. BSR & BHPR guideline on prescribing drugs in pregnancy and breastfeeding. Part II: Analgesics and other drugs used in rheumatology practice. Rheumatology 2016; 55 (9) 1698-702
  15. Burke O, et al, for the Global Pregnancy Collaboration. Extending the scope of pooled analyses of individual patient biomarker data from heterogeneous laboratory platforms and cohorts using merging algorithms. Pregnancy Hypertension 2016; 6(1): 53-59
  16. Staff AC, Redman CWG, Williams D et al for the Global Pregnancy Collaboration (CoLab). Pregnancy and long-term maternal cardiovascular health: progress through harmonization of research cohorts and biobanks. Hypertension 2016; 67 (2): 251-60.
  17. Hillman SL, Finer S, Smart MC, Mathews C, Lowe R, Rakyan VK, Hitman GA, Williams DJ. Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates Epigenetics; 2015; 10 (1): 50-61
  18. Finer S, Mathews C, Lowe R, Smart M, Hillman S, Foo L, Sinha A, Williams D, Rakyan VK, Hitman GA. Maternal Gestational Diabetes Is Associated with Genome-wide DNA Methylation Variation in Placenta and Cord Blood Of Exposed Offspring. Human Molecular Genetics 2015; 24 (11): 3021-9
  19. Abu-Hayyeh S, et al. Prognostic and Mechanistic Potential of Progesterone Sulfates in Intrahepatic Cholestasis of Pregnancy and Pruritus Gravidarum. Hepatology, 2015 DOI: 10.1002/hep.28265
  20. Hypponen E, Cavadino A, Williams D, et al Vitamin D and pre-eclampsia: original data, systematic review and meta-analysis. Annals of Nutrition and Metabolism 2013; 63 (4): 331-40.
  21. Minassian C, Thomas SL, Williams DJ, Campbell O, Smeeth L. Acute maternal infection and risk of pre-eclampsia: a population-based case-control study. Plos One (2013 journal.pone.0073047)
  22. Hillman S, Peebles DM, Williams DJ. Paternal Metabolic and Cardiovascular Risk Factors for Fetal Growth Restriction: A case-control study. Diabetes Care 2013; 36 (6): 1675-1680
  23. Cetin I, Huppertz B, Burton G, Cuckle H, Gonen R, Lapaire O, Mandia L, Nicolaides K, Redman C, Soothill P, Spencer K, Thilaganathan B, Williams D, Meiri H. Pregenesys pre-eclampsia markers consensus: What do we require from markers, risk assessment and model systems to tailor preventative strategies? Placenta 2011; 32: S4-S16
  24. Noori M, Donald AE, Angelakopoulou A, Hingorani AD, Williams DJ. Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension. Circulation 2010; 122: 478-487
  25. Visintin C, Mugglestone MA, Almerie MQ, Nherera LM, James D, Walkinshaw S on behalf of the Guideline Development Group. BMJ 2010; 341: c2207
  26. David AL, Ataullah I, Yates R, Sullivan I, Charles P, Williams D. Congenital fetal heart block: a potential therapeutic role for intravenous immunoglobulin. Obstetrics & Gynecology 2010; 116: (2 Pt 2): 543-7
  27. Bellamy L, Casas JP, Hingorani AD, Williams DJ. Type 2 Diabetes mellitus after Gestational Diabetes: a systematic review and meta-analysis. Lancet, 2009; 373: 1773-79.
  28. Bachy V, Williams DJ, Ibrahim MAA. Altered dendritic cell function in normal pregnancy. J Reprod Immunol 2008; 78: 11-21.
  29. Pipkin FB, Kalsheker N, Morgan L, O’Malley S, Henfrey M, (46 others) and Williams D. Smoking in moderate/severe preeclampsia worsens pregnancy outcome, but smoking cessation limits the damage. Hypertension 2008; 51 (4) 1042-6.
  30. Bellamy L, Casas JP, Hingorani AD, Williams DJ. Pre-eclampsia and the risk of cardiovascular disease and cancer in later life: a systematic review and meta-analysis. BMJ 2007; 335: 974-977
  31. Pipkin FB, Kalsheker N, Morgan L, O’Malley S, Henfrey M, (46 others) and Williams D. Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. J Hypertension 2007; 25: 849-854.
  32. Ghaem-Maghami S, Cook H, Bird A & Williams D. High myopia and pre-eclampsia: a blinding combination. BJOG 2006; 113: 608-609.
  33. Kandil H, Bachy V, Williams DJ, Helmi R, Gotch FM, Ibrahim MAA. Regulation of dendritic cell interleukin-12 secretion by tumour cell necrosis. Clinical and Experimental Immunology 2005; 140(1): 54-64.
  34. Goulis DG, Chappell L, Gibbs RGJ, Williams D, Dave JR, Taylor P, de Swiet M, Poston L, Williamson C. Association of raised titres of antibodies to Chlamydia pneumoniae with a history of pre-eclampsia. BJOG 2005; 112: 299-305.
  35. Genetics of Pre-eclampsia Collaborative (GOPEC) Consortium. Disentangling fetal and maternal susceptibility for pre-eclampsia: A British multicentre candidate-gene study. The American Journal of Human Genetics 2005; 77: 127-131
  36. Williams DI, Williams DJ, Williams IG, Unwin RJ, Griffiths MH, Miller RF. Presentation, pathology and outcome of HIV associated renal disease in a specialist centre for HIV/AIDS. Sexually Transmitted Infections 1998; 74: 179-184.
  37. Williams DJ, Vallance PJT, Neild GH, Spencer JAD, Imms FJ. Nitric oxide mediated vaso-dilatation in human pregnancy. American Journal Physiology (Heart Circ, 41) 1997; 272: H748-52.
  38. MacAllister RJ, Rambausek MH, Vallance P, Williams DJ, Hoffman K, Ritz E. Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure. Nephrology Dialysis Transplantation 1996; 11: 2449-52.
  39. Gordge MP, Williams DJ, Hugget NJ, Payne NN, Neild GH. Loss of biological activity of arginine vasopressin during its degradation by vasopressinase from pregnancy serum. Clinical Endocrinology 1995; 42: 51-58.
  40. Gordge MP, Robson SC, Williams DJ, Payne N, Neild GH. Serum vasopressinase and platelet responses to arginine vasopressin in normal pregnancy, pregnancy induced hypertension and pre-eclampsia. Platelets 1994; 5: 90-95.
  41. Williams DJ, Jugurnauth J, Harding K, Woolfson RG, Mansell MA. Acute hypernatraemia during bicarbonate-buffered haemodialysis. Nephrology, Dialysis, Transplantation 1994; 9: 1170-73.
  42. Woolfson RG, Cairns HS, Williams DJ, Hilson AJW, Neild GH. Renal scintigraphy in acute scleroderma: Report of three cases. Journal of Nuclear Medicine 1993; 34: 1163-65.
  43. Fickling S, Williams D, Vallance P, Nussey S, Whitley G. Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia. Lancet 1993; 342: 242-3.
  44. Williams DJ, Metcalfe KA, Skingle L, Stock AI, Beedham T, Monson JP. Pathophysiology of transient cranial diabetes insipidus during pregnancy. Clinical Endocrinology 1993; 38: 595-600.
  45. Woolfson RG, Williams DJ. Free haemoglobin and pre-eclampsia. Lancet 1990; 336: 1504

Reviews, Editorials and Book Chapters (2020-2022)

  1. Cornish EF, McDonnell T, Williams DJ. Chronic Inflammatory Placental Disorders Associated with Recurrent Adverse Pregnancy Outcome. Frontiers in Immunology.
  2. Goulden B, Youngstein T, Giles I, Manson JJ, Williams D. Haemophagocytic Lympho-histiocytosis in Pregnancy. Clinical Medicine 2021; 21: e682-3. DOI: 10.7861/clinmed.Let.21.6.2
  3. Goulden B, Giles I, Williams D. Postpartum venous thromboprophylaxis needs to be stratified in inflammatory diseases. BJOG: An International Journal of Obstetrics & Gynaecology 2021.
  4. Cornish EF, Filipovic I, Asenius F, Williams DJ, McDonnell T. Innate immune responses to acute viral infection during pregnancy. Frontiers in Immunology. 30.9.20.   doi.org/10.3389/fimmu.2020.572567
  5. Cohen H, Cuadrado MJ, Erkan D, Duarte Garcia A, Isenberg D, Knight J, Ortel T, Rahman A, Salmon J, Tektonidou M, Williams D, Willis R, Woller S, de Andrade D. 16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends. Lupus 2020; 29: (12) 1571-1593
  6. Williams DJ. Physiological changes of normal pregnancy. In Oxford Textbook of Medicine (6th edition), 2020. Eds, Firth JD, Conlon C, Cox TM, Oxford University Press, Oxford, 14.1: DOI: 10.1093/ med/9780198746690.003.0263
  7. Williams DJ. Nutrition in Pregnancy. In Oxford Textbook of Medicine (6th edition), 2020. Eds, Firth JD, Conlon C, Cox TM. Oxford University Press, Oxford, 14.2: DOI: 10.1093/med/ 9780198746690.003.0264
  8. Williams DJ. Medical Management of normal pregnancy. In Oxford Textbook of Medicine (6th edition), 2020. Eds, Firth JD, Conlon C, Cox TM. Oxford University Press, Oxford, 14.3: DOI: 10.1093/med/9780198746690.003.0265
  9. Williams DJ. Renal Disease in Pregnancy. The Oxford Textbook of Obstetrics and Gynaecology. Eds, Arulkumaran S, Ledger W, Denny L and Doumouchtsis S. 2020. Chapter 14; Edition 1. ISBN: 9780198766360
  10. Myers J, Kenny LC and Williams DJ. Medical Complications of Pregnancy. Obstetrics by Ten Teachers. Eds Kenny LC and Myers J. 20th Edition. 2017. CRC Press.
  11. Williams DJ (Guest Editor). Maternal Medicine. Best Practice and Research Clinical Obstetrics and Gynaecology. 2015: Vol 29.5 (doi:10.1016/j.bpobgyn.2015.04.008)
  12. Williams DJ and Mayahi L. Maternal illness in pregnancy. In Rennie and Robertson’s Textbook of Neonatology. Fifth edition. Editor, Rennie JM. Churchill Livingstone, Elsevier (2012).
  13. Wright HV and Williams DJ. Thyrotoxicosis in Pregnancy. Fetal and Maternal Medicine Review 2013; 24: 2 108-128
  14. Williams D. Pre-eclampsia and long-term health. J Obstetric Medicine 2012; 5: 98-104
  15. Williams D and Craft N. Pre-eclampsia. BMJ 2012; 345: e4437 doi: 1136/bmj.e4437
  16. Williams D. Pregnancy outcome – a fertile barometer for women’s health. International Journal of Epidemiology 2011; 40: 920-921.
  17. Nelson-Piercy C, Mackillop L, Williams DJ, Williamson C, de Swiet M, Redman C. Maternal mortality in the UK and the need for obstetric physicians. BMJ 2011; 343: d4993.
  18. Smeeth L and Williams D. Can a dietary supplement prevent pre-eclampsia? BMJ 2011; 342; d2777
  19. Williams DJ. Long-term complications of preeclampsia. Seminars in Nephrology 2011; 31: 111-122.
  20. Visintin C, Mugglestone MA, Almerie MQ, et al. Guideline Development Group. Management of hypertensive disorders during pregnancy: summary of NICE guidance. BMJ 2010 Aug 25; 341: c2207
  21. Williams DJ. Physiological changes of normal pregnancy. In Oxford Textbook of Medicine (fifth edition). Eds, Warrell DA, Cox TM, Firth JD & Benz EJ. Oxford University Press, Oxford, 13.1, 383-385, (2010)
  22. Williams DJ. Nutrition in Pregnancy. In Oxford Textbook of Medicine (fifth edition). Eds, Warrell DA, Cox TM, Firth JD & Benz EJ. Oxford University Press, Oxford, 13.2, (2010)
  23. Williams DJ. Medical Management of normal pregnancy. In Oxford Textbook of Medicine (fifth edition). Eds, Warrell DA, Cox TM, Firth JD & Benz EJ. Oxford University Press, Oxford, 13.3, (2010)
  24. Heaney DC, Williams DJ, O’Brien P, Elton C. Neurological disorders in pregnancy. de Swiet’s Medical Disorders in Obstetric Practice. Eds Powrie RO, Greene MF, Camann W. Fifth Edition, Chapter 15, pg 371-403, Wiley-Blackwell (2010)
  25. Williams DJ. Future health concerns for women who have had a complicated pregnancy. de Swiet’s Medical Disorders in Obstetric Practice. Eds Powrie RO, Greene MF, Camann W. Fifth Edition, Chapter 26, pg 606-614, Wiley-Blackwell (2010)
  26. Kenyon A, Adamason AP, Williams DJ. Physiology of Pregnancy In Basic Science in Obstetrics and Gynaecology. A Textbook for MRCOG part 1. (Fourth edition) Eds Bennett and Williamson (2010)
  27. Williams D and Davison J. Chronic Kidney Disease in Pregnancy. BMJ 2008; 336: 211-215.
  28. Williams DJ. Acute and Chronic Renal Disorders in Pregnancy. In Medical Care of the pregnant patient. American College of Physicians, Books Program, Philadephia, USA Pp182-199, (2008)
  29. Williams DJ and Mayahi L.  Prescribing in pregnancy. Maternal medicines and the fetus Rodeck & Whittle’s Fetal Development 2nd Edition, Pp 158-180. (2008).
  30. Williams D & Lightstone L. Renal Disorders. In Maternal Medicine. Pp 53-69. Eds Greer, Nelson-Piercy and Walters. Churchill Livingstone Elsevier, Edinburgh, UK, (2007)
  31. Williams DJ. Acute renal failure in pregnancy: causes not due to pre-eclampsia. In Renal Disease in Pregnancy. Pp179-88. Eds Davison, Nelson-Piercy, Kehoe & Baker. RCOG Press, London. (2007).
  32. Williams DJ. Pregnancy with pre-existing kidney disease. In Comprehensive Clinical Nephrology, 3rd Edition. Eds, J. Feehally, J. Floege, R. Johnson. Pub Mosby Elsevier 42; 495-504 (2007).
  33. Noori M, Savvidou M & Williams DJ. Endothelial Factors. In Pre-eclampsia: Etiology and Clinical Practice. Eds, Lyall & Belfort. Cambridge University Press, Cambridge. pp 50-77, (2007).
  34. Williams DJ and de Swiet M. Cardiac disease in pregnancy. In The Textbook of Perinatal Medicine, 2nd edition. Ed in chief Asim Kurjak 195, 2076-2090; (2006).
  35. Williams DJ. Renal Disorders in Pregnancy. In High Risk Pregnancy. (Third Edition) Elsevier Saunders, Philadelphia, Pennsylvania. Eds James DK, Steer PJ, Weiner CP & Gonik B. pp 1098-1124 (2006).
  36. Lupton MGF, Williams DJ. The ethics of research on pregnant women: is maternal consent sufficient?’ BJOG: an International Journal of Obstetrics and Gynaecology 2004; 111: 1307-1312
  37. Williams DJ. Pregnancy: a stress test for life. Current Opin Obstet & Gynecol 2003; 15: 465-471.
  38. Williams DJ. Renal Disease in Pregnancy. In Evidence Based Obstetrics. Eds David James, Kassam Mahomed, Peter Stone, Wim Van Wijngaarden and Lyndon Hill, Saunders, Elsevier Science Ltd, Edinburgh. Pp 254-261 (2003).
  39. Williams DJ. Physiological changes of normal pregnancy. In Oxford Textbook of Medicine (fourth edition). Eds, Warrell DA, Cox TM, Firth JD & Benz EJ. Oxford University Press, Oxford, 13.1, 383-385, (2003).
  40. Williams DJ. Nutrition in Pregnancy. In Oxford Textbook of Medicine (fourth edition). Eds, Warrell DA, Cox TM, Firth JD & Benz EJ. Oxford University Press, Oxford, 13.2, 386-389 (2003).
  41. Williams DJ. Medical management of normal pregnancy. In Oxford Textbook of Medicine (fourth edition). Eds, Warrell DA, Cox TM, Firth JD & Benz EJ. Oxford University Press, Oxford, 13.3, 390-395 (2003).
  42. Poston L and Williams DJ. Vascular function in normal pregnancy and pre-eclampsia. pp 398-425. In An Introduction to Vascular Biology, eds BJ Hunt, L Poston, M Schachter and A Halliday. Cambridge University Press, Cambridge, (2002).
  43. Williams DJ and Poston L. The endothelium in pregnancy. Pp 189-193. In Basic Science in Obstetrics and Gynaecology, (Third Edition), eds. de Swiet M, Chamberlain G & Bennett P. Churchill Livingstone (2002).
  44. Williams DJ. Pregnancy and the Heart. pp 47-59. In Vignettes for the MRCOG, 3, ed. RG Farquharson Mark Allen Publishing Ltd, Bath, (2001).
  45. Williams DJ. Renal Disease and Fluid Balance in Pregnancy. Current Obstetrics & Gynaecology, 11, 146-152 (2001).
  46. Poston L and Williams DJ. The Endothelium in Human Pregnancy. pp 247-281. In Vascular Endothelium in Human Physiology and Pathophysiology, eds P. Vallance and D. Webb. Harwood Academic Publishers, Amsterdam, (2000).
  47. Williams DJ. Pregnancy and the Heart. Hospital Medicine, 60, 100-104, (1999).
  48. Williams DJ. The implications of pre-existing renal disease in pregnancy. Current Obstetrics & Gynaecology, 9, 75-81, (1999).
  49. Williams DJ and de Swiet M. Cardiac disease in Pregnancy. pp 1928-1943, In Textbook of Perinatal Medicine. ed. A. Kurjak (ed), (1998).
  50. Williams DJ. Pre-eclampsia. In Critical Care Cases.  eds. RF Armstrong and JB Salmon (eds) 205-8, (1997).
  51. Williams DJ. Renal Disease in pregnancy. Curr Obstet Gynaecol, 7, 156-62, (1997).
  52. Williams DJ, de Swiet M. Pathophysiology of Pre-eclampsia. Intensive Care Medicine 23, 620-29 (1997).
  53. Monson JP, Williams DJ. Osmoregulatory adaptation in pregnancy and its disorders. J Endocrinology 132, 7-9 (1992).
  54. Williams DJ, Monson JP. Diabetes insipidus in pregnancy. J Nephrology 5, 62-9 (1992).