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Overview
Our major research themes are the identification of cancer biomarkers and understanding the molecular basis of carcinogenesis through the application of quantitative proteomic technologies and other molecular biology techniques.
This research is funded through the Eve Appeal Gynaecological Cancer Trust, CR UK, MRC, Pancreatic Cancer UK and the UCLH Biomedical Research Centre.
Facilities include:
- a biochemistry laboratory
- dedicated clean rooms for high-sensitivity, low-contamination sample handling
- fluorescence 2D difference gel electrophoresis (2D-DIGE) capability
- liquid-handling robotics and liquid chromatography (LC) for protein and peptide separations
- mass spectrometry (MS) instrumentation for expression profiling and protein/peptide characterisation (Thermo LTQ Orbitrap XL hybrid mass spectrometer with Dionex3000 nano-LC system and Bruker Ultraflex MALDI-TOF/TOF instrument)
Our mission is to also establish a core resource in proteomics, to provide technical expertise and knowledge in proteomic applications and data interpretation, to promote interaction between clinical and basic scientists and to provide training for the next generation of proteomics research scientists.
Above all, we wish to make a difference to healthcare by addressing important questions in disease through the application of proteomic technologies.