Wolfson Institute for Biomedical Research



WIBR Seminar

'Experimental gene therapy for focal epilepsy'

Professor Dimitri Kullman


UCL Institute of Neurology

Host: Dr Beverley Clark

Epilepsy is common and frequently resistant to medication. Surgical removal of the seizure focus is effective but irreversible, and is associated with risks to language, vision and other functions. We have pursued several strategies based on viral vectors to reduce neuronal or circuit excitability. Potassium channel overexpression is effective and well tolerated but irreversible. Optogenetics is effective and can be used on-demand, but requires invasive light delivery and expression of non-mammalian proteins which may not always be safe. Chemogenetics avoids these pitfalls, and is amenable to clinical translation.

Date: Monday 28th November 2016
Time: 4pm (please arrive 15 mins before start) 
Venue: Cruciform Café, 1st Floor Cruciform Building, Gower Street, UCL, WC1E 6BT
Refreshments will be provided
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