Wolfson Institute for Biomedical Research

The Wolfson Institute for Biomedical Research was established at UCL in 1995 for the pursuit of excellence in translational biomedical research. Now, with its primary focus on fundamental and translational neuroscience, the WIBR is a key hub within the rich environment of the UCL neuroscience community.

Research

The WIBR is currently home to 14 Principal Investigators, including established senior academics as well as early-career scientists. Collectively we hold more than £25m in grants from The European Research Council, MRC, BBSRC, Wellcome and other biomedical research charities.

Teaching

Researchers within the WIBR organise and contribute to several distinguised undergraduate modules within the School of Life and Medical Sciences. The Institute has around 20 current PhD students, and runs a highly rated one-year MSc degree course in Drug Design.

Staff

Contact details for WIBR staff

Contact Us

Our address and location

2022 Publications

Kim, H., Kim, H., Cho, H., Lee, B., Lu, H. -. J., Kim, K., . . . Oh, U. (2022). Anoctamin 1/TMEM16A in pruritoceptors is essential for Mas-related G protein receptor-dependent itch. Pain. doi:10.1097/j.pain.0000000000002611
Iseppon, F., Linley, J. E., & Wood, J. N. (2022). Calcium imaging for analgesic drug discovery. Neurobiology of Pain, 11, 100083. doi:10.1016/j.ynpai.2021.100083
Wood, J. N. (2022). Pain, purines and Geoff. AUTONOMIC NEUROSCIENCE, 237, ARTN 102902. doi:10.1016/j.autneu.2021.102902
Lischka, A., Lassuthova, P., Çakar, A., Record, C. J., Van Lent, J., Baets, J., . . . Kurth, I. (2022). Genetic pain loss disorders. Nature Reviews Disease Primers, 8 (1), 41. doi:10.1038/s41572-022-00365-7
Klasfauseweh, T., Israel, M. R., Ragnarsson, L., Cox, J. J., Durek, T., Carter, D. A., . . . Deuis, J. R. (2022). Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation. European Journal of Pharmacology, 925, 175013. doi:10.1016/j.ejphar.2022.175013
Deuis, J. R., Ragnarsson, L., Robinson, S. D., Dekan, Z., Chan, L., Jin, A. -. H., . . . Vetter, I. (2022). The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation. Frontiers in Pharmacology, 12, 789570. doi:10.3389/fphar.2021.789570
Grinkevich, V. V., Vema, A., Fawkner, K., Issaeva, N., Andreotti, V., Dickinson, E. R., . . . Zawacka-Pankau, J. E. (2022). Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule. Frontiers in Molecular Biosciences, 9, 823195. doi:10.3389/fmolb.2022.823195
Russell, L. E., Dalgleish, H. W. P., Nutbrown, R., Gauld, O. M., Herrmann, D., Fişek, M., . . . Häusser, M. (2022). All-optical interrogation of neural circuits in behaving mice. Nature Protocols. doi:10.1038/s41596-022-00691-w
Kostadinov, D., & Häusser, M. (2022). Reward signals in the cerebellum: origins, targets, and functional implications. Neuron. doi:10.1016/j.neuron.2022.02.015
Kessaris, N. (2022). Human cortical interneuron development unraveled. Science, 375 (6579), 383-384. doi:10.1126/science.abn6333
Smith, R. J., Perez-Ternero, C., Conole, D., Martin, C., Myers, S. H., Hobbs, A. J., & Selwood, D. L. (2022). A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.1c01974
Ramirez, A., Old, W., Selwood, D. L., & Liu, X. (2022). Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles. European Journal of Cell Biology, 101 (1), 151185. doi:10.1016/j.ejcb.2021.151185
Radin, D. P., Caponegro, M., Smith, G., Moushiaveshi, V., Selwood, D., & Tsirka, S. (2022). Studies on the function of myeloid-derived Neuropilin-1 in glioma: a focus on tumor hypoxia. doi:10.1096/fasebj.2022.36.S1.R5521
Mills, C., Hemkemeyer, S. A., Alimajstorovic, Z., Bowers, C., Eskandarpour, M., Greenwood, J., . . . Balda, M. S. (2022). Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease. Cells, 11 (11), 1733. doi:10.3390/cells11111733
Eldrid, C., Zloh, M., Fotinou, C., Yelland, T., Yu, L., Mota, F., . . . Djordjevic, S. (2022). VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins. Biomolecules, 12 (3), 372. doi:10.3390/biom12030372
Guo, L., Luong, V., Gregson, A., Baker, D., Selwood, D., & Cordeiro, M. F. (2022). VSN16S, an agonist of the cannabinoid receptor, reduces IOP profiles and exhibits neuroprotective properties in a rat model of glaucoma. doi:10.1111/j.1755-3768.2022.116
Jiang, J., Ju, J., Luo, L., Song, Z., Liao, H., Yang, X., . . . Li, N. (2022). Salmon Calcitonin Exerts an Antidepressant Effect by Activating Amylin Receptors. Frontiers in Pharmacology, 13, 826055. doi:10.3389/fphar.2022.826055