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The articles in this blog will focus on the main barriers to translational research and how to overcome these.

Early Career Innovators: Genetic Diagnosis of Inherited Retinal Disease with AI, Devices & Diagnostics TIN

In this Devices & Diagnostics TIN interview as part of the Early Career Innovators series, acknowledging the amazing translational work being done by early career researchers within the UCL Therapeutic Innovation Networks (TINs), Dr Nikolas Pontikos highlights his Devices & Diagnostics TIN (co-lead by the UCL Institute of Healthcare Engineering’s Translational & Industry Delivery Group) Pilot Data Fund awarded project, involving the use of artificial intelligence to accelerate genetic diagnosis of inherited retinal disease.

Early Career Innovators: Understanding the Role of Brain Oxygenation in Multiple Sclerosis, Devices & Diagnostics TIN

In this next Devices & Diagnostics TIN interview as part of the Early Career Innovators series, acknowledging the amazing translational work being done by early career researchers within the UCL Therapeutic Innovation Networks (TINs), Dr Frédéric Lange highlights his Devices & Diagnostics TIN (co-lead by the UCL Institute of Healthcare Engineering’s Translational & Industry Delivery Group) Pilot Data Fund awarded project, “Understanding the role of brain oxygenation and metabolism in the pathophysiology and prognosis of relapses and progression in multiple s

Early Career Innovators: Personalised Therapy for Prostate Cancer from Diagnosis, Devices & Diagnostics TIN

In the first Devices & Diagnostics TIN interview as part of the Early Career Innovators series, acknowledging the amazing translational work being done by early career researchers within the UCL Therapeutic Innovation Networks (TINs), Dr Hayley Pye highlights her Devices & Diagnostics TIN (co-lead by the UCL Institute of Healthcare Engineering’s Translational & Industry Delivery Group) Pilot Data Fund awarded project, “Personalising pathology for prostate cancer, a unique opportunity at UCL/UCLH”.

Gene Therapy explained: Changing our bodies’ recipe to treat disease

Written by Linda von Nerée, NIHR Blood and Transplant Research Unit in Stem Cells and Immunotherapies at UCL.

How many pairs of jeans do you have in your wardrobe? How many genes are in your body? What are genes anyway and do you know how they can help to treat an illness?!

All is explained in this brand-new animation from us at the NIHR Blood and Transplant Research Unit in Stem Cells and Immunotherapies at University College London (UCL BTRU). Well, except how many jeans you own, that stays your secret.

Early Career Innovators: Enhancing Stathmin-2 protein in Neurodegenerative Diseases, Small Molecules TIN

In the next Small Molecules TIN interview as part of the Early Career Innovators series, acknowledging the amazing translational work being done by early career researchers within the UCL Therapeutic Innovation Networks (TINs), Benedikt Hölbling highlights his Small Molecules TIN Pilot Data Fund awarded project, “Enhancing Stathmin-2 protein levels in familial and sporadic ALS/FTD”.

Early Career Innovators: Therapeutic Vulnerabilities of an Oncoprotein in Tumour Initiation, Small Molecules TIN

In the next Small Molecules TIN interview as part of the Early Career Innovators series, acknowledging the amazing translational work being done by early career researchers within the UCL Therapeutic Innovation Networks (TINs), Dr Victor Llombart highlights his Small Molecules TIN Pilot Data Fund awarded project, “Identifying therapeutic vulnerabilities of MYC through next generation structure-function”.

Early Career Innovators: Screening a DNA Encoded Library for Drugs Targeting Ocular Diseases, Small Molecules TIN

In the first Small Molecules TIN interview as part of the Early Career Innovators series, acknowledging the amazing translational work being done by early career researchers within the UCL Therapeutic Innovation Networks (TINs), Clara Gathmann highlights her Small Molecules TIN Pilot Data Fund awarded project, “Screening a DNA encoded library on GEF-H1 for drugs targeting ocular diseases”.

Investigating Plasma Exchange as a Treatment of Severe COVID-19 Infection

Professor Marie Scully is a professor of haemostasis and thrombosis at UCL and a Consultant Haematologist working in non-malignant haematology at UCLH. Professor Scully has recently received a grant of around £360,000 grant from LifeArc for a phase 2 study to investigate the impact of COVID-19 on thrombosis and a potential mitigation therapy through plasma exchange.

What changes does COVID-19 cause in the blood and what does this mean for patients?

Early Career Innovators: Blocking LRG1 in Pancreatic Cancer, Biologics TIN

In the next interview as part of the Early Career Innovators series, acknowledging the amazing translational work being done by early career researchers within the UCL Therapeutic Innovation Networks, Dr Athina Dritsoula and Dr Carlotta Camilli highlight their joint Biologics TIN Pilot Data Fund awarded project focusing on the effect of LRG1 blockade in pancreatic cancer.

How did this joint project come about?

Early Career Innovators: Treating Antimicrobrial Resistant Pathogens with Monoclonal Antibodies, Biologics TIN

In the third interview as part of the Early Career Innovators series, acknowledging the amazing translational work being done by early career researchers within the UCL Therapeutic Innovation Networks, Dr Gathoni Kamuyu highlights her Biologics TIN Pilot Data Fund awarded project “Identifying monoclonal antibodies for the treatment of Acinetobacter baumannii infections” and presents some advice for future applicants.

Please provide an overview of your Biologics TIN Pilot Data Fund awarded project. 

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