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Towers Lab

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Towers Lab

In the Towers Lab we aim to understand the molecular details of host virus interactions particularly with respect to innate immunity. We consider novel therapeutic approaches for viral infection and inflammation and use viruses to help us understand mammalian cell biology and evolution. We also want to know what is special about pandemic viruses HIV-1(M) and SARS-CoV-2 and how have they adapted to replicate in humans and cause disease.

NEWS

 

We are recruiting!

The positions are funded by the NIH grant Antivirals Drug Discovery (AViDD) Centers, led by Nevan Krogan from the UCSF Quantitative Biosciences Institute in San Francisco. The UCL project, led by Professors Greg Towers and Clare Jolly is to characterise novel compounds identified by AViDD collaborators to have demonstrated anti-SARS-CoV-2 activity. We will compare antiviral activity against variants of concern (VOCs) and characterise their mechanisms of action. We are particularly interested in measuring whether inhibitors influence host innate immune response to infection, as may be expected when viral innate immune antagonists are targeted. The project builds on previous collaborative work between the Krogan, Jolly and Towers laboratories characterising innate immune responses to SARS-CoV-2 VOCs (Thorne et al, EMBO-J 2021, Nature, 2021) and their sensitivity to novel inhibitors (Varona et al, Life Sci Alliance, 2022).

More information about the posts can be found on our 'Work with Us' page or go directly to the UCL recruitment page for these posts

 

 


False coloured SEM image of 283T cells in culture. Image is copyrighted. It was taken on SEM by Steve Gschmeissner. To see more of his work, visit http://theworldcloseup.com/
Virtual Virology

The Towers laboratory we share with the Gupta and Rowe labs. Image courtsey of the Wellcome Trust
The Lab

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Work with Us

False coloured SEM image of a platelet found as a contaminant in a primary monocyte culture. Image is copyrighted. It was taken on SEM by Steve Gschmeissner. To see more of his work, visit http://theworldcloseup.com/
Contact Us

 


We are funded by a Senior Biomedical Research Fellowship No 108183 from Wellcome to Professor Greg Towers and a Wellcome collaborative award as well as grants from the Medical Research Council and the National Institute for Health Research.

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