Tissue-engineered tracheal tissue implants

Professors Martin Birchall of the Ear Institute, Paolo de Coppi of ICH GOS and Mark Lowdell of the Cancer Institute developed, manufactured and performed FIH tissue-engineered adult and paediatric tracheal tissue implants constructed from decellularized donor trachea seeded with recipient mesenchymal stromal cells.

Phase I/II clinical trials for tissue engineered laryngeal, tracheal and oesophageal implants are active/in set-up.