Adaptive & Responsive Nanomaterials Group


Nanoparticle building blocks with tailored size and surface functionalisation

Many of our applications rely on detailed control over the size and surface functionality of nanoparticles. To this end, we have recently developed an approach that allows us to synthesise gold nanoparticles in a modular fashion with detailed and independent control over both the core diameter and the ligand architecture. Our research is informed by the routine implementation of statistical tools, including Design of Experiment and our recently developed Nanoparticle Entropy method. Furthermore, we have established a novel method for the quantitative study of nanoparticle-stimuli interaction via immobilisation of NPs on a quartz crystal microbalance and use this technique for the rapid screening and validation of molecular recognition.

Overview figure nanoparticle building blocks

Key Publications

DoE-It-Yourself: A case study for implementing design of experiments into nanoparticle synthesis (link)
N Mac Fhionnlaoich, Y Yang, R Qi, F Galvanin, S Guldin
Under review. Available as preprint on ChemrXiv, DOI: 10.26434/chemrxiv.8198420.v1.

Comparative characterisation of non-monodisperse gold nanoparticle populations by X-ray scattering and electron microscopy (link)
Y Yang, S Liao, Z Luo, R Qi, N MacFhionnlaoich, F Stellacci, S Guldin
Nanoscale, vol. 12, pp. 12007 – 12013 (2020).

Synthetic guidelines for the precision engineering of gold nanoparticles (link)
JW Trzcinski, L Panariello, MO Besenhard, Y Yang, A Gavriilidis, S Guldin
Current Opinions in Chemical Engineering, vol. 29, pp. 59 – 66 (2020).

Information entropy as a reliable measure of nanoparticle dispersity (link)
N MacFhionnlaoich, S Guldin,
Chemistry of Materials, vol. 32, pp. 3701 – 3706 (2020).

Probing the interaction of nanoparticles with small molecules in real-time via quartz crystal microbalance monitoring (link)
Y Yang, G Poss, Y Weng, R Qi, H Zheng, N Nianias, ER Kay, S Guldin
Nanoscale vol 11, pp 11107 - 11113 (2019)

A versatile AuNP synthetic platform for decoupled control of size and surface composition (link)
Y Yang, LA Serrano, S Guldin
Langmuir vol 24, pp 6820-6826 (2018)