Pain: The Good, the Bad, and the Ugly (Dr James Cox)
31 March 2021
MadeAtUCL Podcast S2 Ep3
Dr James Cox is a Senior Lecturer and Deputy Graduate Tutor working in the Molecular Nociception Group at the UCL Wolfson Institute for Biomedical Research. James is a human geneticist using DNA sequencing to find mutations in genes that are important for pain perception. He is also developing gene therapy approaches to help treat people with chronic pain disorders and has a keen interest in the endocannabinoid system and the biology of non-coding RNAs.
The FAAH-OUT gene discovery was widely reported in the media (Altmetric score in the top 100 for 2019), with the research featured in the New York Times, New Yorker, National Geographic, Smithsonian Magazine and the BBC. You can read the published manuscript here and further data from the FAAH-OUT research project can be found here.
Listen to the podcast
- Dr James Cox | Wolfson Institute for Biomedical Research - UCL – University College London
- Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity - ScienceDirect
- CRISPR interference at the FAAH-OUT genomic region reduces FAAH expression | bioRxiv